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Degradation of neutrophil extracellular traps is decreased in patients with antiphospholipid syndrome.

Leffler, Jonatan LU ; Stojanovich, Ljudmila; Shoenfeld, Yehuda; Bogdanovic, Gordana; Hesselstrand, Roger LU and Blom, Anna LU (2014) In Clinical and Experimental Rheumatology 32(1). p.66-70
Abstract
A decreased ability to degrade neutrophil extracellular traps (NETs) is seen in a subgroup of patients with systemic lupus erythematosus (SLE) and correlates with the presence of autoantibodies. Antiphospholipid syndrome (APS) can develop secondary to SLE or as a primary disease. In the current study we investigated the ability of sera from patients with APS to degrade NETs. The presence of antibodies against NETs and neutrophil remnants were also determined in the same patients.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical and Experimental Rheumatology
volume
32
issue
1
pages
66 - 70
publisher
Pacini
external identifiers
  • pmid:24295292
  • wos:000332682100011
  • scopus:84894058233
ISSN
1593-098X
language
English
LU publication?
yes
id
a93129c3-cdbf-4cbe-8ab2-3c08b63366b8 (old id 4225364)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24295292?dopt=Abstract
date added to LUP
2014-01-07 19:49:17
date last changed
2017-10-29 03:15:43
@article{a93129c3-cdbf-4cbe-8ab2-3c08b63366b8,
  abstract     = {A decreased ability to degrade neutrophil extracellular traps (NETs) is seen in a subgroup of patients with systemic lupus erythematosus (SLE) and correlates with the presence of autoantibodies. Antiphospholipid syndrome (APS) can develop secondary to SLE or as a primary disease. In the current study we investigated the ability of sera from patients with APS to degrade NETs. The presence of antibodies against NETs and neutrophil remnants were also determined in the same patients.},
  author       = {Leffler, Jonatan and Stojanovich, Ljudmila and Shoenfeld, Yehuda and Bogdanovic, Gordana and Hesselstrand, Roger and Blom, Anna},
  issn         = {1593-098X},
  language     = {eng},
  number       = {1},
  pages        = {66--70},
  publisher    = {Pacini},
  series       = {Clinical and Experimental Rheumatology},
  title        = {Degradation of neutrophil extracellular traps is decreased in patients with antiphospholipid syndrome.},
  volume       = {32},
  year         = {2014},
}