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The mechanism of protein kinase C regulation

Kazi, Julhash U. LU (2011) In Frontiers in Biology 6(4). p.328-336
Abstract
Protein kinase C (PKC) is a family of serine/threonine protein kinases that plays a central role in transducing extracellular signals into a variety of intracellular responses ranging from cell proliferation to apoptosis. Nine PKC genes have been identified in the human genome, which encode 10 proteins. Each member of this protein kinase family displays distinct biochemical characteristics and is enriched in different cellular and subcellular locations. Activation of PKC has been implicated in the regulation of cell growth and differentiation. This review summarizes works of the past years in the field of PKC biochemistry that covers regulation and activation mechanism of different PKC isoforms.
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
PKC biochemistry PKC kinase PKC phosphatases PKC structure
in
Frontiers in Biology
volume
6
issue
4
pages
328 - 336
external identifiers
  • scopus:79961042749
language
English
LU publication?
no
id
c0b9f558-152b-4ff3-a8e0-a40ad7608671 (old id 4250285)
alternative location
http://link.springer.com/article/10.1007/s11515-011-1070-5
date added to LUP
2014-02-13 17:17:15
date last changed
2017-02-19 14:40:18
@article{c0b9f558-152b-4ff3-a8e0-a40ad7608671,
  abstract     = {Protein kinase C (PKC) is a family of serine/threonine protein kinases that plays a central role in transducing extracellular signals into a variety of intracellular responses ranging from cell proliferation to apoptosis. Nine PKC genes have been identified in the human genome, which encode 10 proteins. Each member of this protein kinase family displays distinct biochemical characteristics and is enriched in different cellular and subcellular locations. Activation of PKC has been implicated in the regulation of cell growth and differentiation. This review summarizes works of the past years in the field of PKC biochemistry that covers regulation and activation mechanism of different PKC isoforms.},
  author       = {Kazi, Julhash U.},
  keyword      = {PKC biochemistry PKC kinase PKC phosphatases PKC structure},
  language     = {eng},
  number       = {4},
  pages        = {328--336},
  series       = {Frontiers in Biology},
  title        = {The mechanism of protein kinase C regulation},
  volume       = {6},
  year         = {2011},
}