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Non-invasive mapping of deep-tissue lymph nodes in live animals using a multimodal PET/MRI nanoparticle.

Thorek, Daniel L J; Ulmert, David LU ; Diop, Ndeye-Fatou M; Lupu, Mihaela E; Doran, Michael G; Huang, Ruimin; Abou, Diane S; Larson, Steven M and Grimm, Jan (2014) In Nature Communications 5(Jan 20).
Abstract
The invasion status of tumour-draining lymph nodes (LNs) is a critical indicator of cancer stage and is important for treatment planning. Clinicians currently use planar scintigraphy and single-photon emission computed tomography (SPECT) with (99m)Tc-radiocolloid to guide biopsy and resection of LNs. However, emerging multimodality approaches such as positron emission tomography combined with magnetic resonance imaging (PET/MRI) detect sites of disease with higher sensitivity and accuracy. Here we present a multimodal nanoparticle, (89)Zr-ferumoxytol, for the enhanced detection of LNs with PET/MRI. For genuine translational potential, we leverage a clinical iron oxide formulation, altered with minimal modification for radiolabelling.... (More)
The invasion status of tumour-draining lymph nodes (LNs) is a critical indicator of cancer stage and is important for treatment planning. Clinicians currently use planar scintigraphy and single-photon emission computed tomography (SPECT) with (99m)Tc-radiocolloid to guide biopsy and resection of LNs. However, emerging multimodality approaches such as positron emission tomography combined with magnetic resonance imaging (PET/MRI) detect sites of disease with higher sensitivity and accuracy. Here we present a multimodal nanoparticle, (89)Zr-ferumoxytol, for the enhanced detection of LNs with PET/MRI. For genuine translational potential, we leverage a clinical iron oxide formulation, altered with minimal modification for radiolabelling. Axillary drainage in naive mice and from healthy and tumour-bearing prostates was investigated. We demonstrate that (89)Zr-ferumoxytol can be used for high-resolution tomographic studies of lymphatic drainage in preclinical disease models. This nanoparticle platform has significant translational potential to improve preoperative planning for nodal resection and tumour staging. (Less)
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author
organization
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Contribution to journal
publication status
published
subject
in
Nature Communications
volume
5
issue
Jan 20
publisher
Nature Publishing Group
external identifiers
  • pmid:24445347
  • wos:000331084400006
  • scopus:84892861543
ISSN
2041-1723
DOI
10.1038/ncomms4097
language
English
LU publication?
yes
id
b8505917-aee0-4471-81f9-1d35355b91c5 (old id 4291013)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24445347?dopt=Abstract
date added to LUP
2014-02-07 16:00:20
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2017-11-19 03:45:47
@article{b8505917-aee0-4471-81f9-1d35355b91c5,
  abstract     = {The invasion status of tumour-draining lymph nodes (LNs) is a critical indicator of cancer stage and is important for treatment planning. Clinicians currently use planar scintigraphy and single-photon emission computed tomography (SPECT) with (99m)Tc-radiocolloid to guide biopsy and resection of LNs. However, emerging multimodality approaches such as positron emission tomography combined with magnetic resonance imaging (PET/MRI) detect sites of disease with higher sensitivity and accuracy. Here we present a multimodal nanoparticle, (89)Zr-ferumoxytol, for the enhanced detection of LNs with PET/MRI. For genuine translational potential, we leverage a clinical iron oxide formulation, altered with minimal modification for radiolabelling. Axillary drainage in naive mice and from healthy and tumour-bearing prostates was investigated. We demonstrate that (89)Zr-ferumoxytol can be used for high-resolution tomographic studies of lymphatic drainage in preclinical disease models. This nanoparticle platform has significant translational potential to improve preoperative planning for nodal resection and tumour staging.},
  articleno    = {3097},
  author       = {Thorek, Daniel L J and Ulmert, David and Diop, Ndeye-Fatou M and Lupu, Mihaela E and Doran, Michael G and Huang, Ruimin and Abou, Diane S and Larson, Steven M and Grimm, Jan},
  issn         = {2041-1723},
  language     = {eng},
  number       = {Jan 20},
  publisher    = {Nature Publishing Group},
  series       = {Nature Communications},
  title        = {Non-invasive mapping of deep-tissue lymph nodes in live animals using a multimodal PET/MRI nanoparticle.},
  url          = {http://dx.doi.org/10.1038/ncomms4097},
  volume       = {5},
  year         = {2014},
}