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Functional subsets of mesenchymal cell types in the tumor microenvironment.

Cortez, Eliane LU ; Roswall, Pernilla and Pietras, Kristian LU (2014) In Seminars in Cancer Biology 25(Jan 7). p.3-9
Abstract
In the field of tumor biology, increasing attention is now focused on the complex interactions between various constituent cell types within the tumor microenvironment as being functionally important for the etiology of the disease. The detailed description of tumor-promoting properties of cancer-associated fibroblasts, endothelial cells, pericytes, and immune cells, introduces novel potential drug targets for improved cancer treatments, as well as a rationale for exploring the tumor stroma as a previously unchartered source for prognostic or predictive biomarkers. However, recent work highlights the fact that cellular identity is perhaps too broadly defined and that subdivision of each cell type may reveal functionally distinct subsets of... (More)
In the field of tumor biology, increasing attention is now focused on the complex interactions between various constituent cell types within the tumor microenvironment as being functionally important for the etiology of the disease. The detailed description of tumor-promoting properties of cancer-associated fibroblasts, endothelial cells, pericytes, and immune cells, introduces novel potential drug targets for improved cancer treatments, as well as a rationale for exploring the tumor stroma as a previously unchartered source for prognostic or predictive biomarkers. However, recent work highlights the fact that cellular identity is perhaps too broadly defined and that subdivision of each cell type may reveal functionally distinct subsets of cells. Here, we will review our current understanding of the diversity of different subsets of mesenchymal cells, i.e., cancer-associated fibroblasts and pericytes, residing within the tumor parenchyma. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Seminars in Cancer Biology
volume
25
issue
Jan 7
pages
3 - 9
publisher
Academic Press
external identifiers
  • pmid:24412106
  • wos:000335614800002
  • scopus:84897476556
ISSN
1096-3650
DOI
10.1016/j.semcancer.2013.12.010
language
English
LU publication?
yes
id
6d0acf99-2808-423d-9fa2-2b5c15a7e25f (old id 4291609)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24412106?dopt=Abstract
date added to LUP
2014-02-08 11:11:03
date last changed
2017-10-01 03:29:10
@article{6d0acf99-2808-423d-9fa2-2b5c15a7e25f,
  abstract     = {In the field of tumor biology, increasing attention is now focused on the complex interactions between various constituent cell types within the tumor microenvironment as being functionally important for the etiology of the disease. The detailed description of tumor-promoting properties of cancer-associated fibroblasts, endothelial cells, pericytes, and immune cells, introduces novel potential drug targets for improved cancer treatments, as well as a rationale for exploring the tumor stroma as a previously unchartered source for prognostic or predictive biomarkers. However, recent work highlights the fact that cellular identity is perhaps too broadly defined and that subdivision of each cell type may reveal functionally distinct subsets of cells. Here, we will review our current understanding of the diversity of different subsets of mesenchymal cells, i.e., cancer-associated fibroblasts and pericytes, residing within the tumor parenchyma.},
  author       = {Cortez, Eliane and Roswall, Pernilla and Pietras, Kristian},
  issn         = {1096-3650},
  language     = {eng},
  number       = {Jan 7},
  pages        = {3--9},
  publisher    = {Academic Press},
  series       = {Seminars in Cancer Biology},
  title        = {Functional subsets of mesenchymal cell types in the tumor microenvironment.},
  url          = {http://dx.doi.org/10.1016/j.semcancer.2013.12.010},
  volume       = {25},
  year         = {2014},
}