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Variation in the PTH2R gene is associated with age-related degenerative changes in the lumbar spine.

Åkesson, Kristina LU ; Tenne, Max LU ; Gerdhem, Paul LU ; Luthman, Holger LU and McGuigan, Fiona LU (2015) In Journal of Bone and Mineral Metabolism 33(1). p.9-15
Abstract
In the elderly, degenerative changes in the lumbar spine are common, contributing to falsely elevated bone mineral density (BMD) values. The parathyroid hormone (PTH) system plays an important role in the regulation of bone turnover and we explore the hypothesis that polymorphisms (SNPs) within genes in this pathway (PTH, PTHLH, PTH1R and PTH2R) contribute to degenerative manifestations of the spine in elderly women. The study included 1,004 Swedish women aged 75 years from the population-based OPRA cohort who attended follow-up at 5 and 10 years. Lumbar spine BMD was assessed by dual energy X-ray absorptiometry (DXA) and each individual vertebra was evaluated visually on the DXA image for apparent degenerative manifestations. Six SNPs in... (More)
In the elderly, degenerative changes in the lumbar spine are common, contributing to falsely elevated bone mineral density (BMD) values. The parathyroid hormone (PTH) system plays an important role in the regulation of bone turnover and we explore the hypothesis that polymorphisms (SNPs) within genes in this pathway (PTH, PTHLH, PTH1R and PTH2R) contribute to degenerative manifestations of the spine in elderly women. The study included 1,004 Swedish women aged 75 years from the population-based OPRA cohort who attended follow-up at 5 and 10 years. Lumbar spine BMD was assessed by dual energy X-ray absorptiometry (DXA) and each individual vertebra was evaluated visually on the DXA image for apparent degenerative manifestations. Six SNPs in PTH and 3 SNPs each in PTH1R, PTH2R and PTHLH were analysed. Among women with degenerative manifestations at the lumbar spine, there was an over-representation at baseline of those carrying the PTH2R SNP rs897083 A-allele (p = 0.0021; odds ratio 1.5 95 % CI 1.2-2.0) and across the duration of follow-up (p = 0.0008). No association was observed between degenerative manifestations and variation in the other genes. None of the PTH hormone system genes were associated with vertebral fracture. Variation in the PTH2R gene (Chr2q34, rs897083) may contribute to the age-associated degenerative manifestations that develop at the lumbar spine. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Bone and Mineral Metabolism
volume
33
issue
1
pages
9 - 15
publisher
Springer
external identifiers
  • pmid:24378925
  • wos:000347407900002
  • scopus:84944459904
ISSN
0914-8779
DOI
10.1007/s00774-013-0550-x
language
English
LU publication?
yes
id
ed586815-a5e7-43c1-8ba5-864f78a3e461 (old id 4292300)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24378925?dopt=Abstract
date added to LUP
2014-02-08 22:47:15
date last changed
2017-01-01 04:02:53
@article{ed586815-a5e7-43c1-8ba5-864f78a3e461,
  abstract     = {In the elderly, degenerative changes in the lumbar spine are common, contributing to falsely elevated bone mineral density (BMD) values. The parathyroid hormone (PTH) system plays an important role in the regulation of bone turnover and we explore the hypothesis that polymorphisms (SNPs) within genes in this pathway (PTH, PTHLH, PTH1R and PTH2R) contribute to degenerative manifestations of the spine in elderly women. The study included 1,004 Swedish women aged 75 years from the population-based OPRA cohort who attended follow-up at 5 and 10 years. Lumbar spine BMD was assessed by dual energy X-ray absorptiometry (DXA) and each individual vertebra was evaluated visually on the DXA image for apparent degenerative manifestations. Six SNPs in PTH and 3 SNPs each in PTH1R, PTH2R and PTHLH were analysed. Among women with degenerative manifestations at the lumbar spine, there was an over-representation at baseline of those carrying the PTH2R SNP rs897083 A-allele (p = 0.0021; odds ratio 1.5 95 % CI 1.2-2.0) and across the duration of follow-up (p = 0.0008). No association was observed between degenerative manifestations and variation in the other genes. None of the PTH hormone system genes were associated with vertebral fracture. Variation in the PTH2R gene (Chr2q34, rs897083) may contribute to the age-associated degenerative manifestations that develop at the lumbar spine.},
  author       = {Åkesson, Kristina and Tenne, Max and Gerdhem, Paul and Luthman, Holger and McGuigan, Fiona},
  issn         = {0914-8779},
  language     = {eng},
  number       = {1},
  pages        = {9--15},
  publisher    = {Springer},
  series       = {Journal of Bone and Mineral Metabolism},
  title        = {Variation in the PTH2R gene is associated with age-related degenerative changes in the lumbar spine.},
  url          = {http://dx.doi.org/10.1007/s00774-013-0550-x},
  volume       = {33},
  year         = {2015},
}