Serum levels of insulin-like growth factor I and insulin-like growth factor-binding protein 1 correlate with serum free testosterone and sex hormone binding globulin levels in healthy young and middle-aged men
(1996) In Clinical Endocrinology 44(6). p.64-659- Abstract
OBJECTIVE: Administration of testosterone has been reported to increase serum levels of IGF-I in men with isolated hypogonadotrophic hypogonadism. An inverse relation between serum IGF-I and sex hormone binding globulin (SHBG) is seen in GH deficient children. The biological action of IGF-I is thought to be influenced by binding proteins, one of which is insulin-like growth factor-binding protein-1 (IGFBP-1), which is not only a carrier protein but also actively regulates the cellular actions of IGF-I. These observations suggest associations between IGF-I, IGFBP-1, testosterone and SHBG in serum. The aim of the present study was to investigate these associations in normal healthy men.
DESIGN AND PATIENTS: The associations between... (More)
OBJECTIVE: Administration of testosterone has been reported to increase serum levels of IGF-I in men with isolated hypogonadotrophic hypogonadism. An inverse relation between serum IGF-I and sex hormone binding globulin (SHBG) is seen in GH deficient children. The biological action of IGF-I is thought to be influenced by binding proteins, one of which is insulin-like growth factor-binding protein-1 (IGFBP-1), which is not only a carrier protein but also actively regulates the cellular actions of IGF-I. These observations suggest associations between IGF-I, IGFBP-1, testosterone and SHBG in serum. The aim of the present study was to investigate these associations in normal healthy men.
DESIGN AND PATIENTS: The associations between the serum levels of IGF-I and IGFBP-1 on one hand, and testosterone and SHBG on the other were investigated in 38 normal healthy young and middle-aged men.
RESULTS: Serum levels of IGF-I decreased both with increasing age (r = -0.66, P < 0.001) and increasing SHBG levels (r = -0.46, P = 0.002), but increased with increasing free testosterone (f-testosterone) (r = 0.42, P = 0.005). These associations remained after mutual simultaneous adjustments in a multiple regression analysis. IGFBP-1 did not display any significant univariate correlation with age (r = -0.25, P = 0.06) or SHBG (r = 0.18, P = 0.14), but showed a significant positive correlation with both f-testosterone (r = 0.42, P = 0.004), and total testosterone (t-testosterone) (r = 0.39, P = 0.008). In a multiple regression analysis IGFBP-1 was positively correlated with both SHBG and f-testosterone, but not with t-testosterone.
CONCLUSION: The present study suggests that among healthy young and middle-aged men, there is an association between serum levels of free-testosterone and SHBG on the one hand, and serum IGF-I and IGFBP-1 on the other.
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- author
- Erfurth, E M LU ; Hagmar, L E LU ; Sääf, M and Hall, K
- organization
- publishing date
- 1996
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adult, Age Factors, Humans, Insulin-Like Growth Factor Binding Protein 1/blood, Insulin-Like Growth Factor I/analysis, Male, Middle Aged, Regression Analysis, Sex Hormone-Binding Globulin/analysis, Testosterone/blood
- in
- Clinical Endocrinology
- volume
- 44
- issue
- 6
- pages
- 64 - 659
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:0029955199
- pmid:8801037
- ISSN
- 0300-0664
- DOI
- 10.1046/j.1365-2265.1996.731552.x
- language
- English
- LU publication?
- yes
- id
- 42d328c4-dcf0-4e1d-888d-03f7a48d7923
- date added to LUP
- 2023-11-27 09:31:17
- date last changed
- 2024-02-25 21:46:04
@article{42d328c4-dcf0-4e1d-888d-03f7a48d7923, abstract = {{<p>OBJECTIVE: Administration of testosterone has been reported to increase serum levels of IGF-I in men with isolated hypogonadotrophic hypogonadism. An inverse relation between serum IGF-I and sex hormone binding globulin (SHBG) is seen in GH deficient children. The biological action of IGF-I is thought to be influenced by binding proteins, one of which is insulin-like growth factor-binding protein-1 (IGFBP-1), which is not only a carrier protein but also actively regulates the cellular actions of IGF-I. These observations suggest associations between IGF-I, IGFBP-1, testosterone and SHBG in serum. The aim of the present study was to investigate these associations in normal healthy men.</p><p>DESIGN AND PATIENTS: The associations between the serum levels of IGF-I and IGFBP-1 on one hand, and testosterone and SHBG on the other were investigated in 38 normal healthy young and middle-aged men.</p><p>RESULTS: Serum levels of IGF-I decreased both with increasing age (r = -0.66, P < 0.001) and increasing SHBG levels (r = -0.46, P = 0.002), but increased with increasing free testosterone (f-testosterone) (r = 0.42, P = 0.005). These associations remained after mutual simultaneous adjustments in a multiple regression analysis. IGFBP-1 did not display any significant univariate correlation with age (r = -0.25, P = 0.06) or SHBG (r = 0.18, P = 0.14), but showed a significant positive correlation with both f-testosterone (r = 0.42, P = 0.004), and total testosterone (t-testosterone) (r = 0.39, P = 0.008). In a multiple regression analysis IGFBP-1 was positively correlated with both SHBG and f-testosterone, but not with t-testosterone.</p><p>CONCLUSION: The present study suggests that among healthy young and middle-aged men, there is an association between serum levels of free-testosterone and SHBG on the one hand, and serum IGF-I and IGFBP-1 on the other.</p>}}, author = {{Erfurth, E M and Hagmar, L E and Sääf, M and Hall, K}}, issn = {{0300-0664}}, keywords = {{Adult; Age Factors; Humans; Insulin-Like Growth Factor Binding Protein 1/blood; Insulin-Like Growth Factor I/analysis; Male; Middle Aged; Regression Analysis; Sex Hormone-Binding Globulin/analysis; Testosterone/blood}}, language = {{eng}}, number = {{6}}, pages = {{64--659}}, publisher = {{Wiley-Blackwell}}, series = {{Clinical Endocrinology}}, title = {{Serum levels of insulin-like growth factor I and insulin-like growth factor-binding protein 1 correlate with serum free testosterone and sex hormone binding globulin levels in healthy young and middle-aged men}}, url = {{http://dx.doi.org/10.1046/j.1365-2265.1996.731552.x}}, doi = {{10.1046/j.1365-2265.1996.731552.x}}, volume = {{44}}, year = {{1996}}, }