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Serum levels of insulin-like growth factor I and insulin-like growth factor-binding protein 1 correlate with serum free testosterone and sex hormone binding globulin levels in healthy young and middle-aged men

Erfurth, E M LU ; Hagmar, L E LU ; Sääf, M and Hall, K (1996) In Clinical Endocrinology 44(6). p.64-659
Abstract

OBJECTIVE: Administration of testosterone has been reported to increase serum levels of IGF-I in men with isolated hypogonadotrophic hypogonadism. An inverse relation between serum IGF-I and sex hormone binding globulin (SHBG) is seen in GH deficient children. The biological action of IGF-I is thought to be influenced by binding proteins, one of which is insulin-like growth factor-binding protein-1 (IGFBP-1), which is not only a carrier protein but also actively regulates the cellular actions of IGF-I. These observations suggest associations between IGF-I, IGFBP-1, testosterone and SHBG in serum. The aim of the present study was to investigate these associations in normal healthy men.

DESIGN AND PATIENTS: The associations between... (More)

OBJECTIVE: Administration of testosterone has been reported to increase serum levels of IGF-I in men with isolated hypogonadotrophic hypogonadism. An inverse relation between serum IGF-I and sex hormone binding globulin (SHBG) is seen in GH deficient children. The biological action of IGF-I is thought to be influenced by binding proteins, one of which is insulin-like growth factor-binding protein-1 (IGFBP-1), which is not only a carrier protein but also actively regulates the cellular actions of IGF-I. These observations suggest associations between IGF-I, IGFBP-1, testosterone and SHBG in serum. The aim of the present study was to investigate these associations in normal healthy men.

DESIGN AND PATIENTS: The associations between the serum levels of IGF-I and IGFBP-1 on one hand, and testosterone and SHBG on the other were investigated in 38 normal healthy young and middle-aged men.

RESULTS: Serum levels of IGF-I decreased both with increasing age (r = -0.66, P < 0.001) and increasing SHBG levels (r = -0.46, P = 0.002), but increased with increasing free testosterone (f-testosterone) (r = 0.42, P = 0.005). These associations remained after mutual simultaneous adjustments in a multiple regression analysis. IGFBP-1 did not display any significant univariate correlation with age (r = -0.25, P = 0.06) or SHBG (r = 0.18, P = 0.14), but showed a significant positive correlation with both f-testosterone (r = 0.42, P = 0.004), and total testosterone (t-testosterone) (r = 0.39, P = 0.008). In a multiple regression analysis IGFBP-1 was positively correlated with both SHBG and f-testosterone, but not with t-testosterone.

CONCLUSION: The present study suggests that among healthy young and middle-aged men, there is an association between serum levels of free-testosterone and SHBG on the one hand, and serum IGF-I and IGFBP-1 on the other.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Age Factors, Humans, Insulin-Like Growth Factor Binding Protein 1/blood, Insulin-Like Growth Factor I/analysis, Male, Middle Aged, Regression Analysis, Sex Hormone-Binding Globulin/analysis, Testosterone/blood
in
Clinical Endocrinology
volume
44
issue
6
pages
64 - 659
publisher
Wiley-Blackwell
external identifiers
  • scopus:0029955199
  • pmid:8801037
ISSN
0300-0664
DOI
10.1046/j.1365-2265.1996.731552.x
language
English
LU publication?
yes
id
42d328c4-dcf0-4e1d-888d-03f7a48d7923
date added to LUP
2023-11-27 09:31:17
date last changed
2024-02-25 21:46:04
@article{42d328c4-dcf0-4e1d-888d-03f7a48d7923,
  abstract     = {{<p>OBJECTIVE: Administration of testosterone has been reported to increase serum levels of IGF-I in men with isolated hypogonadotrophic hypogonadism. An inverse relation between serum IGF-I and sex hormone binding globulin (SHBG) is seen in GH deficient children. The biological action of IGF-I is thought to be influenced by binding proteins, one of which is insulin-like growth factor-binding protein-1 (IGFBP-1), which is not only a carrier protein but also actively regulates the cellular actions of IGF-I. These observations suggest associations between IGF-I, IGFBP-1, testosterone and SHBG in serum. The aim of the present study was to investigate these associations in normal healthy men.</p><p>DESIGN AND PATIENTS: The associations between the serum levels of IGF-I and IGFBP-1 on one hand, and testosterone and SHBG on the other were investigated in 38 normal healthy young and middle-aged men.</p><p>RESULTS: Serum levels of IGF-I decreased both with increasing age (r = -0.66, P &lt; 0.001) and increasing SHBG levels (r = -0.46, P = 0.002), but increased with increasing free testosterone (f-testosterone) (r = 0.42, P = 0.005). These associations remained after mutual simultaneous adjustments in a multiple regression analysis. IGFBP-1 did not display any significant univariate correlation with age (r = -0.25, P = 0.06) or SHBG (r = 0.18, P = 0.14), but showed a significant positive correlation with both f-testosterone (r = 0.42, P = 0.004), and total testosterone (t-testosterone) (r = 0.39, P = 0.008). In a multiple regression analysis IGFBP-1 was positively correlated with both SHBG and f-testosterone, but not with t-testosterone.</p><p>CONCLUSION: The present study suggests that among healthy young and middle-aged men, there is an association between serum levels of free-testosterone and SHBG on the one hand, and serum IGF-I and IGFBP-1 on the other.</p>}},
  author       = {{Erfurth, E M and Hagmar, L E and Sääf, M and Hall, K}},
  issn         = {{0300-0664}},
  keywords     = {{Adult; Age Factors; Humans; Insulin-Like Growth Factor Binding Protein 1/blood; Insulin-Like Growth Factor I/analysis; Male; Middle Aged; Regression Analysis; Sex Hormone-Binding Globulin/analysis; Testosterone/blood}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{64--659}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Clinical Endocrinology}},
  title        = {{Serum levels of insulin-like growth factor I and insulin-like growth factor-binding protein 1 correlate with serum free testosterone and sex hormone binding globulin levels in healthy young and middle-aged men}},
  url          = {{http://dx.doi.org/10.1046/j.1365-2265.1996.731552.x}},
  doi          = {{10.1046/j.1365-2265.1996.731552.x}},
  volume       = {{44}},
  year         = {{1996}},
}