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Identification of gut microbiome signatures and metabolites associated with albuminuria in type 2 diabetes

Lin, Yi-Ting ; Sayols-Baixeras, Sergi ; Graells, Tiscar ; Dekkers, Koen F ; Baldanzi, Gabriel LU ; Nguyen, Diem ; Larsson, Anders ; Feldreich, Tobias Rudholm ; Nielsen, Nynne and Eklund, Aron C , et al. (2025) In The Journal of clinical endocrinology and metabolism
Abstract

CONTEXT: Type 2 diabetes is a growing global concern with serious complications, including kidney damage and cardiovascular morbidity and mortality. Monitoring albuminuria, which is associated with these complications, is crucial in optimal diabetes management. Gut microbiota composition has been suggested to impact albuminuria, but large studies with granular data are lacking.

METHODS: We investigated the relationship between 1002 gut microbial species, 1308 plasma metabolites and albuminuria in 752 participants with type 2 diabetes from the Swedish CArdioPulmonary BioImage Study. To determine the relative abundance of species, we employed deep shotgun metagenomic sequencing of fecal samples. Plasma metabolites were analyzed... (More)

CONTEXT: Type 2 diabetes is a growing global concern with serious complications, including kidney damage and cardiovascular morbidity and mortality. Monitoring albuminuria, which is associated with these complications, is crucial in optimal diabetes management. Gut microbiota composition has been suggested to impact albuminuria, but large studies with granular data are lacking.

METHODS: We investigated the relationship between 1002 gut microbial species, 1308 plasma metabolites and albuminuria in 752 participants with type 2 diabetes from the Swedish CArdioPulmonary BioImage Study. To determine the relative abundance of species, we employed deep shotgun metagenomic sequencing of fecal samples. Plasma metabolites were analyzed using mass spectrometry-based methods.

RESULTS: We identified three species that were associated with albuminuria, including Sellimonas intestinalis, Eggerthellales sp., Ellagibacter isourolithinifaciens. Two of these species were replicated in an independent pre-diabetic population (n=3,423) in SCAPIS. In total, 36 annotated metabolites were associated with the three albuminuria-signature species. Functional mapping of the signature species suggests a role in the regulation of the metabolites of imidazole propionate and trigonelline, which have previously been reported to play roles in the progression of albuminuria.

CONCLUSIONS: These findings provide additional evidence of the potential impact of microbial species and contribute to our understanding of the complex relationship between the gut microbiome, plasma metabolites, and albuminuria in individuals with diabetes.

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Contribution to journal
publication status
epub
subject
in
The Journal of clinical endocrinology and metabolism
article number
dgaf453
publisher
Oxford University Press
external identifiers
  • pmid:40810199
ISSN
1945-7197
DOI
10.1210/clinem/dgaf453
language
English
LU publication?
yes
additional info
© The Author(s) 2025. Published by Oxford University Press on behalf of the Endocrine Society.
id
42e3c168-2e16-45dd-9114-46340efd3322
date added to LUP
2025-08-15 09:28:21
date last changed
2025-10-17 11:07:33
@article{42e3c168-2e16-45dd-9114-46340efd3322,
  abstract     = {{<p>CONTEXT: Type 2 diabetes is a growing global concern with serious complications, including kidney damage and cardiovascular morbidity and mortality. Monitoring albuminuria, which is associated with these complications, is crucial in optimal diabetes management. Gut microbiota composition has been suggested to impact albuminuria, but large studies with granular data are lacking.</p><p>METHODS: We investigated the relationship between 1002 gut microbial species, 1308 plasma metabolites and albuminuria in 752 participants with type 2 diabetes from the Swedish CArdioPulmonary BioImage Study. To determine the relative abundance of species, we employed deep shotgun metagenomic sequencing of fecal samples. Plasma metabolites were analyzed using mass spectrometry-based methods.</p><p>RESULTS: We identified three species that were associated with albuminuria, including Sellimonas intestinalis, Eggerthellales sp., Ellagibacter isourolithinifaciens. Two of these species were replicated in an independent pre-diabetic population (n=3,423) in SCAPIS. In total, 36 annotated metabolites were associated with the three albuminuria-signature species. Functional mapping of the signature species suggests a role in the regulation of the metabolites of imidazole propionate and trigonelline, which have previously been reported to play roles in the progression of albuminuria.</p><p>CONCLUSIONS: These findings provide additional evidence of the potential impact of microbial species and contribute to our understanding of the complex relationship between the gut microbiome, plasma metabolites, and albuminuria in individuals with diabetes.</p>}},
  author       = {{Lin, Yi-Ting and Sayols-Baixeras, Sergi and Graells, Tiscar and Dekkers, Koen F and Baldanzi, Gabriel and Nguyen, Diem and Larsson, Anders and Feldreich, Tobias Rudholm and Nielsen, Nynne and Eklund, Aron C and Holm, Jacob B and Nielsen, H Bjørn and Bergström, Göran and Smith, J Gustav and Malinovschi, Andrei and Engström, Gunnar and Orho-Melander, Marju and Fall, Tove and Ärnlöv, Johan}},
  issn         = {{1945-7197}},
  language     = {{eng}},
  month        = {{08}},
  publisher    = {{Oxford University Press}},
  series       = {{The Journal of clinical endocrinology and metabolism}},
  title        = {{Identification of gut microbiome signatures and metabolites associated with albuminuria in type 2 diabetes}},
  url          = {{http://dx.doi.org/10.1210/clinem/dgaf453}},
  doi          = {{10.1210/clinem/dgaf453}},
  year         = {{2025}},
}