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Alcohol consumption, cigarette smoking, and risk of breast cancer for BRCA1 and BRCA2 mutation carriers : Results from the BRCA1 and BRCA2 cohort consortium

Li, Hongyan ; Terry, Mary Beth ; Antoniou, Antonis C. ; Phillips, Kelly Anne ; Kast, Karin ; Mooij, Thea M. ; Engel, Christoph ; Nogues, Catherine ; Stoppa-Lyonnet, Dominique and Lasset, Christine , et al. (2020) In Cancer Epidemiology Biomarkers and Prevention 29(2). p.368-378
Abstract

Background: Tobacco smoking and alcohol consumption have been intensively studied in the general population to assess their effects on the risk of breast cancer, but very few studies have examined these effects in BRCA1 and BRCA2 mutation carriers. Given the high breast cancer risk for mutation carriers and the importance of BRCA1 and BRCA2 in DNA repair, better evidence on the associations of these lifestyle factors with breast cancer risk is essential. Methods: Using a large international pooled cohort of BRCA1 and BRCA2 mutation carriers, we conducted retrospective (5,707 BRCA1 mutation carriers and 3,525 BRCA2 mutation carriers) and prospective (2,276 BRCA1 mutation carriers and 1,610 BRCA2 mutation carriers) analyses of alcohol and... (More)

Background: Tobacco smoking and alcohol consumption have been intensively studied in the general population to assess their effects on the risk of breast cancer, but very few studies have examined these effects in BRCA1 and BRCA2 mutation carriers. Given the high breast cancer risk for mutation carriers and the importance of BRCA1 and BRCA2 in DNA repair, better evidence on the associations of these lifestyle factors with breast cancer risk is essential. Methods: Using a large international pooled cohort of BRCA1 and BRCA2 mutation carriers, we conducted retrospective (5,707 BRCA1 mutation carriers and 3,525 BRCA2 mutation carriers) and prospective (2,276 BRCA1 mutation carriers and 1,610 BRCA2 mutation carriers) analyses of alcohol and tobacco consumption using Cox proportional hazards models. Results: For both BRCA1 and BRCA2 mutation carriers, none of the smoking-related variables was associated with breast cancer risk, except smoking for more than 5 years before a first full-term pregnancy (FFTP) when compared with parous women who never smoked. For BRCA1 mutation carriers, the HR from retrospective analysis (HRR) was 1.19 [95% confidence interval (CI), 1.02-1.39] and the HR from prospective analysis (HRP) was 1.36 (95% CI, 0.99-1.87). For BRCA2 mutation carriers, smoking for more than 5 years before an FFTP showed an association of a similar magnitude, but the confidence limits were wider (HRR = 1.25; 95% CI, 1.01-1.55 and HRP = 1.30; 95% CI, 0.83-2.01). For both carrier groups, alcohol consumption was not associated with breast cancer risk. Conclusions: The finding that smoking during the prereproductive years increases breast cancer risk for mutation carriers warrants further investigation.

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Contribution to journal
publication status
published
subject
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Cancer Epidemiology Biomarkers and Prevention
volume
29
issue
2
pages
11 pages
publisher
American Association for Cancer Research
external identifiers
  • scopus:85079079985
  • pmid:31792088
ISSN
1055-9965
DOI
10.1158/1055-9965.EPI-19-0546
language
English
LU publication?
no
id
42eec3ee-1dfe-45db-8fd5-627902cf02f6
date added to LUP
2020-03-23 08:03:40
date last changed
2024-06-12 10:41:35
@article{42eec3ee-1dfe-45db-8fd5-627902cf02f6,
  abstract     = {{<p>Background: Tobacco smoking and alcohol consumption have been intensively studied in the general population to assess their effects on the risk of breast cancer, but very few studies have examined these effects in BRCA1 and BRCA2 mutation carriers. Given the high breast cancer risk for mutation carriers and the importance of BRCA1 and BRCA2 in DNA repair, better evidence on the associations of these lifestyle factors with breast cancer risk is essential. Methods: Using a large international pooled cohort of BRCA1 and BRCA2 mutation carriers, we conducted retrospective (5,707 BRCA1 mutation carriers and 3,525 BRCA2 mutation carriers) and prospective (2,276 BRCA1 mutation carriers and 1,610 BRCA2 mutation carriers) analyses of alcohol and tobacco consumption using Cox proportional hazards models. Results: For both BRCA1 and BRCA2 mutation carriers, none of the smoking-related variables was associated with breast cancer risk, except smoking for more than 5 years before a first full-term pregnancy (FFTP) when compared with parous women who never smoked. For BRCA1 mutation carriers, the HR from retrospective analysis (HR<sub>R</sub>) was 1.19 [95% confidence interval (CI), 1.02-1.39] and the HR from prospective analysis (HR<sub>P</sub>) was 1.36 (95% CI, 0.99-1.87). For BRCA2 mutation carriers, smoking for more than 5 years before an FFTP showed an association of a similar magnitude, but the confidence limits were wider (HR<sub>R</sub> = 1.25; 95% CI, 1.01-1.55 and HR<sub>P</sub> = 1.30; 95% CI, 0.83-2.01). For both carrier groups, alcohol consumption was not associated with breast cancer risk. Conclusions: The finding that smoking during the prereproductive years increases breast cancer risk for mutation carriers warrants further investigation.</p>}},
  author       = {{Li, Hongyan and Terry, Mary Beth and Antoniou, Antonis C. and Phillips, Kelly Anne and Kast, Karin and Mooij, Thea M. and Engel, Christoph and Nogues, Catherine and Stoppa-Lyonnet, Dominique and Lasset, Christine and Berthet, Pascaline and Mari, Veronique and Caron, Olivier and Barrowdale, Daniel and Frost, Debra and Brewer, Carole and Evans, D. Gareth and Izatt, Louise and Side, Lucy and Walker, Lisa and Tischkowitz, Marc and Rogers, Mark T. and Porteous, Mary E. and Snape, Katie and Meijers-Heijboer, Hanne E.J. and Gille, Johan J.P. and Blok, Marinus J. and Hoogerbrugge, Nicoline and Daly, Mary B. and Andrulis, Irene L. and Buys, Saundra S. and John, Esther M. and McLachlan, Sue Anne and Friedlander, Michael and Tan, Yen Y. and Osorio, Ana and Caldes, Trinidad and Jakubowska, Anna and Simard, Jacques and Singer, Christian F. and Olah, Edith and Navratilova, Marie and Foretova, Lenka and Gerdes, Anne Marie and Roos-Blom, Marie Jose and Arver, Brita and Olsson, Hakan and Schmutzler, Rita K. and Hopper, John L. and Milne, Roger L. and Easton, Douglas F. and Van Leeuwen, Flora E. and Rookus, Matti A. and Andrieu, Nadine and Goldgar, David E.}},
  issn         = {{1055-9965}},
  language     = {{eng}},
  month        = {{02}},
  number       = {{2}},
  pages        = {{368--378}},
  publisher    = {{American Association for Cancer Research}},
  series       = {{Cancer Epidemiology Biomarkers and Prevention}},
  title        = {{Alcohol consumption, cigarette smoking, and risk of breast cancer for BRCA1 and BRCA2 mutation carriers : Results from the BRCA1 and BRCA2 cohort consortium}},
  url          = {{http://dx.doi.org/10.1158/1055-9965.EPI-19-0546}},
  doi          = {{10.1158/1055-9965.EPI-19-0546}},
  volume       = {{29}},
  year         = {{2020}},
}