Environment influences functional outcome of cerebral infarction in rats
(1995) In Stroke: a journal of cerebral circulation 26(4). p.644-649- Abstract
- BACKGROUND AND PURPOSE: The purpose of this study was to determine whether preoperative and postoperative enrichment of the environment can enhance the functional outcome after cerebral infarction in rats. METHODS: The right middle cerebral artery was ligated in adult spontaneously hypertensive male rats, and the functional outcome was studied for 12 weeks after the operation. Three groups were compared: A, rats kept in individual cages before and after the operation (n = 9); B, rats kept in individual cages before the operation but transferred to an enriched environment after the operation (n = 10); and C, rats kept in an enriched environment all the time (n = 12). The enriched environment consisted of a large cage with opportunities for... (More)
- BACKGROUND AND PURPOSE: The purpose of this study was to determine whether preoperative and postoperative enrichment of the environment can enhance the functional outcome after cerebral infarction in rats. METHODS: The right middle cerebral artery was ligated in adult spontaneously hypertensive male rats, and the functional outcome was studied for 12 weeks after the operation. Three groups were compared: A, rats kept in individual cages before and after the operation (n = 9); B, rats kept in individual cages before the operation but transferred to an enriched environment after the operation (n = 10); and C, rats kept in an enriched environment all the time (n = 12). The enriched environment consisted of a large cage with opportunities for various activities, but rats were not forced to do any particular tasks. RESULTS: Rats kept in an enriched environment (groups B and C) performed significantly better than rats in group A in a leg-placement test, beam walking, walking on a rotating pole, and climbing. The infarct size and thalamic atrophy did not differ among the groups. CONCLUSIONS: The laboratory environment is important for the functional outcome in brain ischemia. We hypothesize that an enriched environment may stimulate mechanisms that enhance brain plasticity after focal brain ischemia. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1109165
- author
- Ohlsson, Anna-Lena and Johansson, Barbro LU
- organization
- publishing date
- 1995
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cerebral infarction, rehabilitation, stroke outcome, rats
- in
- Stroke: a journal of cerebral circulation
- volume
- 26
- issue
- 4
- pages
- 644 - 649
- publisher
- American Heart Association
- external identifiers
-
- pmid:7709412
- scopus:0028906372
- ISSN
- 1524-4628
- language
- English
- LU publication?
- yes
- id
- 4305eadb-9088-4367-9c86-095452cc87af (old id 1109165)
- alternative location
- http://stroke.ahajournals.org/cgi/content/full/26/4/644
- date added to LUP
- 2016-04-01 16:06:52
- date last changed
- 2021-10-10 04:09:35
@article{4305eadb-9088-4367-9c86-095452cc87af,
abstract = {{BACKGROUND AND PURPOSE: The purpose of this study was to determine whether preoperative and postoperative enrichment of the environment can enhance the functional outcome after cerebral infarction in rats. METHODS: The right middle cerebral artery was ligated in adult spontaneously hypertensive male rats, and the functional outcome was studied for 12 weeks after the operation. Three groups were compared: A, rats kept in individual cages before and after the operation (n = 9); B, rats kept in individual cages before the operation but transferred to an enriched environment after the operation (n = 10); and C, rats kept in an enriched environment all the time (n = 12). The enriched environment consisted of a large cage with opportunities for various activities, but rats were not forced to do any particular tasks. RESULTS: Rats kept in an enriched environment (groups B and C) performed significantly better than rats in group A in a leg-placement test, beam walking, walking on a rotating pole, and climbing. The infarct size and thalamic atrophy did not differ among the groups. CONCLUSIONS: The laboratory environment is important for the functional outcome in brain ischemia. We hypothesize that an enriched environment may stimulate mechanisms that enhance brain plasticity after focal brain ischemia.}},
author = {{Ohlsson, Anna-Lena and Johansson, Barbro}},
issn = {{1524-4628}},
keywords = {{cerebral infarction; rehabilitation; stroke outcome; rats}},
language = {{eng}},
number = {{4}},
pages = {{644--649}},
publisher = {{American Heart Association}},
series = {{Stroke: a journal of cerebral circulation}},
title = {{Environment influences functional outcome of cerebral infarction in rats}},
url = {{http://stroke.ahajournals.org/cgi/content/full/26/4/644}},
volume = {{26}},
year = {{1995}},
}