Adrenoceptors mediating contraction in the human uterine artery
(1990) In Human Reproduction 5(1). p.19-24- Abstract
- Pharmacological characterization of adrenoceptors mediating smooth muscle contraction was performed in isolated preparations from the human uterine artery. The mixed alpha 1- and alpha 2-adrenergic agonist, noradrenaline (NA) and the selective alpha 1-agonists, phenylephrine and methoxamine, all contracted the smooth muscle preparations in a concentration-dependent manner. The responses were antagonized competitively by the selective alpha 1-antagonist, prazosin, yielding pA2 values for the three agonists (8.33-9.08) typical for an interaction with alpha 1-receptors. The alpha 2-selective receptor agonists, clonidine and BHT 920, did not exert any contractile effects in the isolated uterine arteries, and the alpha 2-adrenergic antagonist,... (More)
- Pharmacological characterization of adrenoceptors mediating smooth muscle contraction was performed in isolated preparations from the human uterine artery. The mixed alpha 1- and alpha 2-adrenergic agonist, noradrenaline (NA) and the selective alpha 1-agonists, phenylephrine and methoxamine, all contracted the smooth muscle preparations in a concentration-dependent manner. The responses were antagonized competitively by the selective alpha 1-antagonist, prazosin, yielding pA2 values for the three agonists (8.33-9.08) typical for an interaction with alpha 1-receptors. The alpha 2-selective receptor agonists, clonidine and BHT 920, did not exert any contractile effects in the isolated uterine arteries, and the alpha 2-adrenergic antagonist, yohimbine, counteracted the contractile effect of NA only at high concentrations. The concentration-response curve for NA was unaffected by the alpha 2-selective antagonists, rauwolscine and idazoxan. The results suggest that the postjunctional contractile receptors in the human uterine artery primarily are of the alpha 1 type, and give no evidence for any substantial involvement of alpha 2-receptors in this important tributary vessel of the human female reproductive tract. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1105370
- author
- Stjernquist, Martin LU and Owman, Christer LU
- organization
- publishing date
- 1990
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- adrenoceptors/noradrenaline/uterine artery/vascular/smooth muscle
- in
- Human Reproduction
- volume
- 5
- issue
- 1
- pages
- 19 - 24
- publisher
- Oxford University Press
- external identifiers
-
- pmid:2324242
- scopus:0025319271
- ISSN
- 0268-1161
- language
- English
- LU publication?
- yes
- id
- 4307ab09-d758-4837-bed0-5f0ef177088a (old id 1105370)
- alternative location
- http://humrep.oxfordjournals.org/cgi/reprint/5/1/19
- date added to LUP
- 2016-04-01 12:03:30
- date last changed
- 2021-01-03 08:28:39
@article{4307ab09-d758-4837-bed0-5f0ef177088a,
abstract = {{Pharmacological characterization of adrenoceptors mediating smooth muscle contraction was performed in isolated preparations from the human uterine artery. The mixed alpha 1- and alpha 2-adrenergic agonist, noradrenaline (NA) and the selective alpha 1-agonists, phenylephrine and methoxamine, all contracted the smooth muscle preparations in a concentration-dependent manner. The responses were antagonized competitively by the selective alpha 1-antagonist, prazosin, yielding pA2 values for the three agonists (8.33-9.08) typical for an interaction with alpha 1-receptors. The alpha 2-selective receptor agonists, clonidine and BHT 920, did not exert any contractile effects in the isolated uterine arteries, and the alpha 2-adrenergic antagonist, yohimbine, counteracted the contractile effect of NA only at high concentrations. The concentration-response curve for NA was unaffected by the alpha 2-selective antagonists, rauwolscine and idazoxan. The results suggest that the postjunctional contractile receptors in the human uterine artery primarily are of the alpha 1 type, and give no evidence for any substantial involvement of alpha 2-receptors in this important tributary vessel of the human female reproductive tract.}},
author = {{Stjernquist, Martin and Owman, Christer}},
issn = {{0268-1161}},
keywords = {{adrenoceptors/noradrenaline/uterine artery/vascular/smooth muscle}},
language = {{eng}},
number = {{1}},
pages = {{19--24}},
publisher = {{Oxford University Press}},
series = {{Human Reproduction}},
title = {{Adrenoceptors mediating contraction in the human uterine artery}},
url = {{http://humrep.oxfordjournals.org/cgi/reprint/5/1/19}},
volume = {{5}},
year = {{1990}},
}