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Enteral leptin administration affects intestinal autophagy in suckling piglets

Slupecka, M.; Wolinski, J.; Gajewska, M. and Pierzynowski, Stefan LU (2014) In Domestic Animal Endocrinology 46. p.12-19
Abstract
Leptin has been shown to play an integral role in the endocrine regulation of metabolism. Moreover, a substantial amount of this peptide has been found in colostrum and milk. The aim of the study was to investigate the effects of exogenous leptin, administered intragastrically, on the process of autophagy and the changes in cell hyperplasia and hypertrophy in the small intestine mucosa. Three groups (n = 6) of neonatal piglets were used in the study. The pigs were fed either by their sows (sow-reared piglets) or with only milk formula, or with milk formula together with leptin administered via a stomach tube (10 mu g/kg BW) every 8 h for 6 d. We have shown that pure milk formula feeding significantly elevates (P < 0.05) autophagy... (More)
Leptin has been shown to play an integral role in the endocrine regulation of metabolism. Moreover, a substantial amount of this peptide has been found in colostrum and milk. The aim of the study was to investigate the effects of exogenous leptin, administered intragastrically, on the process of autophagy and the changes in cell hyperplasia and hypertrophy in the small intestine mucosa. Three groups (n = 6) of neonatal piglets were used in the study. The pigs were fed either by their sows (sow-reared piglets) or with only milk formula, or with milk formula together with leptin administered via a stomach tube (10 mu g/kg BW) every 8 h for 6 d. We have shown that pure milk formula feeding significantly elevates (P < 0.05) autophagy compared with that observed in sow-reared piglets. Compared with the control group, feeding milk formula supplemented with leptin resulted in a significant decrease (P < 0.05) in immunodetection of microtubule-associated protein 1 light chain 3, as well as significantly accelerated epithelial cell renewal (P < 0.05). We demonstrated that autophagy is involved in the remodeling of the small intestine mucosa and that leptin, when administered enterally, may be an important factor for its regulation. (C) 2014 Elsevier Inc. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Leptin, Intestine, Autophagy, Pig
in
Domestic Animal Endocrinology
volume
46
pages
12 - 19
publisher
Elsevier
external identifiers
  • wos:000329957900002
  • scopus:84892371654
ISSN
0739-7240
DOI
10.1016/j.domaniend.2013.09.007
language
English
LU publication?
yes
id
ba0658b2-417e-43dc-80db-b6195758958c (old id 4319104)
date added to LUP
2014-02-25 14:35:04
date last changed
2017-03-12 03:49:09
@article{ba0658b2-417e-43dc-80db-b6195758958c,
  abstract     = {Leptin has been shown to play an integral role in the endocrine regulation of metabolism. Moreover, a substantial amount of this peptide has been found in colostrum and milk. The aim of the study was to investigate the effects of exogenous leptin, administered intragastrically, on the process of autophagy and the changes in cell hyperplasia and hypertrophy in the small intestine mucosa. Three groups (n = 6) of neonatal piglets were used in the study. The pigs were fed either by their sows (sow-reared piglets) or with only milk formula, or with milk formula together with leptin administered via a stomach tube (10 mu g/kg BW) every 8 h for 6 d. We have shown that pure milk formula feeding significantly elevates (P &lt; 0.05) autophagy compared with that observed in sow-reared piglets. Compared with the control group, feeding milk formula supplemented with leptin resulted in a significant decrease (P &lt; 0.05) in immunodetection of microtubule-associated protein 1 light chain 3, as well as significantly accelerated epithelial cell renewal (P &lt; 0.05). We demonstrated that autophagy is involved in the remodeling of the small intestine mucosa and that leptin, when administered enterally, may be an important factor for its regulation. (C) 2014 Elsevier Inc. All rights reserved.},
  author       = {Slupecka, M. and Wolinski, J. and Gajewska, M. and Pierzynowski, Stefan},
  issn         = {0739-7240},
  keyword      = {Leptin,Intestine,Autophagy,Pig},
  language     = {eng},
  pages        = {12--19},
  publisher    = {Elsevier},
  series       = {Domestic Animal Endocrinology},
  title        = {Enteral leptin administration affects intestinal autophagy in suckling piglets},
  url          = {http://dx.doi.org/10.1016/j.domaniend.2013.09.007},
  volume       = {46},
  year         = {2014},
}