MMP7 Expression in Colorectal Tumours of Different Stages
(2014) In In Vivo 28(1). p.105-110- Abstract
- Background/Aim: Matrix metalloproteinases (MMPs) are involved in cancer biology. Expression of MMP7 (matrilysin) in colorectal cancer is associated with metastatic disease even though it is expressed in most tumour states. In the present study, our purpose was to analyze MMP7 in bowel and lymph nodes of different tumour stages and to evaluate its expression as a cancer biomarker. Patients and Methods: 28 patients surgically-treated for benign and malignant colorectal tumours were recruited and analyzed for MMP7 in tumoural tissue, lymph nodes and serum by histology, immunohistochemistry, ELISA and western blotting. Results: Immunohistochemistu showed prevalent expression of MMP7 in advanced cancer. A significant increase (p < 0.001) was... (More)
- Background/Aim: Matrix metalloproteinases (MMPs) are involved in cancer biology. Expression of MMP7 (matrilysin) in colorectal cancer is associated with metastatic disease even though it is expressed in most tumour states. In the present study, our purpose was to analyze MMP7 in bowel and lymph nodes of different tumour stages and to evaluate its expression as a cancer biomarker. Patients and Methods: 28 patients surgically-treated for benign and malignant colorectal tumours were recruited and analyzed for MMP7 in tumoural tissue, lymph nodes and serum by histology, immunohistochemistry, ELISA and western blotting. Results: Immunohistochemistu showed prevalent expression of MMP7 in advanced cancer. A significant increase (p < 0.001) was evident in serum of stage III/IV cancers compared to both adenomas and non-metastatic disease. MMP7 was increased in cancer tissues with prevalence in stage I/II. Lymph nodes presented a significant increase of MMP7 (p < 0.05 adenoma vs. stage I/II and p < 0.001 vs. stage III/IV). Conclusion: MMP7 increases with dysplasia and cancer disease stage in tumour tissue as well as in the regional lymph nodes. It may be used as a complement in investigating suspected locally advanced cancer. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4319111
- author
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Matrilysin, MMP7, colorectal cancer, adenoma, lymph nodes
- in
- In Vivo
- volume
- 28
- issue
- 1
- pages
- 105 - 110
- publisher
- In vivo
- external identifiers
-
- wos:000329765500014
- scopus:84906924442
- ISSN
- 0258-851X
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Surgery Research Unit (013242220), Emergency medicine/Medicine/Surgery (013240200)
- id
- fda52882-4926-41d5-885e-66f4d4479d3b (old id 4319111)
- date added to LUP
- 2016-04-01 15:04:35
- date last changed
- 2024-11-22 05:39:53
@article{fda52882-4926-41d5-885e-66f4d4479d3b, abstract = {{Background/Aim: Matrix metalloproteinases (MMPs) are involved in cancer biology. Expression of MMP7 (matrilysin) in colorectal cancer is associated with metastatic disease even though it is expressed in most tumour states. In the present study, our purpose was to analyze MMP7 in bowel and lymph nodes of different tumour stages and to evaluate its expression as a cancer biomarker. Patients and Methods: 28 patients surgically-treated for benign and malignant colorectal tumours were recruited and analyzed for MMP7 in tumoural tissue, lymph nodes and serum by histology, immunohistochemistry, ELISA and western blotting. Results: Immunohistochemistu showed prevalent expression of MMP7 in advanced cancer. A significant increase (p < 0.001) was evident in serum of stage III/IV cancers compared to both adenomas and non-metastatic disease. MMP7 was increased in cancer tissues with prevalence in stage I/II. Lymph nodes presented a significant increase of MMP7 (p < 0.05 adenoma vs. stage I/II and p < 0.001 vs. stage III/IV). Conclusion: MMP7 increases with dysplasia and cancer disease stage in tumour tissue as well as in the regional lymph nodes. It may be used as a complement in investigating suspected locally advanced cancer.}}, author = {{Polistena, Andrea and Cucina, Alessandra and Dinicola, Simona and Stene, Christina and Cavallaro, Giuseppe and Ciardi, Antonio and Orlando, Gennaro and Arena, Rossella and D'Ermo, Giuseppe and Cavallaro, Antonino and Johnson, Louis Banka and De Toma, Giorgio}}, issn = {{0258-851X}}, keywords = {{Matrilysin; MMP7; colorectal cancer; adenoma; lymph nodes}}, language = {{eng}}, number = {{1}}, pages = {{105--110}}, publisher = {{In vivo}}, series = {{In Vivo}}, title = {{MMP7 Expression in Colorectal Tumours of Different Stages}}, volume = {{28}}, year = {{2014}}, }