Advanced

MMP7 Expression in Colorectal Tumours of Different Stages

Polistena, Andrea LU ; Cucina, Alessandra; Dinicola, Simona; Stene, Christina LU ; Cavallaro, Giuseppe; Ciardi, Antonio; Orlando, Gennaro; Arena, Rossella; D'Ermo, Giuseppe and Cavallaro, Antonino, et al. (2014) In In Vivo 28(1). p.105-110
Abstract
Background/Aim: Matrix metalloproteinases (MMPs) are involved in cancer biology. Expression of MMP7 (matrilysin) in colorectal cancer is associated with metastatic disease even though it is expressed in most tumour states. In the present study, our purpose was to analyze MMP7 in bowel and lymph nodes of different tumour stages and to evaluate its expression as a cancer biomarker. Patients and Methods: 28 patients surgically-treated for benign and malignant colorectal tumours were recruited and analyzed for MMP7 in tumoural tissue, lymph nodes and serum by histology, immunohistochemistry, ELISA and western blotting. Results: Immunohistochemistu showed prevalent expression of MMP7 in advanced cancer. A significant increase (p < 0.001) was... (More)
Background/Aim: Matrix metalloproteinases (MMPs) are involved in cancer biology. Expression of MMP7 (matrilysin) in colorectal cancer is associated with metastatic disease even though it is expressed in most tumour states. In the present study, our purpose was to analyze MMP7 in bowel and lymph nodes of different tumour stages and to evaluate its expression as a cancer biomarker. Patients and Methods: 28 patients surgically-treated for benign and malignant colorectal tumours were recruited and analyzed for MMP7 in tumoural tissue, lymph nodes and serum by histology, immunohistochemistry, ELISA and western blotting. Results: Immunohistochemistu showed prevalent expression of MMP7 in advanced cancer. A significant increase (p < 0.001) was evident in serum of stage III/IV cancers compared to both adenomas and non-metastatic disease. MMP7 was increased in cancer tissues with prevalence in stage I/II. Lymph nodes presented a significant increase of MMP7 (p < 0.05 adenoma vs. stage I/II and p < 0.001 vs. stage III/IV). Conclusion: MMP7 increases with dysplasia and cancer disease stage in tumour tissue as well as in the regional lymph nodes. It may be used as a complement in investigating suspected locally advanced cancer. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Matrilysin, MMP7, colorectal cancer, adenoma, lymph nodes
in
In Vivo
volume
28
issue
1
pages
105 - 110
publisher
In vivo
external identifiers
  • wos:000329765500014
  • scopus:84906924442
ISSN
0258-851X
language
English
LU publication?
yes
id
fda52882-4926-41d5-885e-66f4d4479d3b (old id 4319111)
date added to LUP
2014-03-03 07:58:44
date last changed
2017-09-24 04:15:59
@article{fda52882-4926-41d5-885e-66f4d4479d3b,
  abstract     = {Background/Aim: Matrix metalloproteinases (MMPs) are involved in cancer biology. Expression of MMP7 (matrilysin) in colorectal cancer is associated with metastatic disease even though it is expressed in most tumour states. In the present study, our purpose was to analyze MMP7 in bowel and lymph nodes of different tumour stages and to evaluate its expression as a cancer biomarker. Patients and Methods: 28 patients surgically-treated for benign and malignant colorectal tumours were recruited and analyzed for MMP7 in tumoural tissue, lymph nodes and serum by histology, immunohistochemistry, ELISA and western blotting. Results: Immunohistochemistu showed prevalent expression of MMP7 in advanced cancer. A significant increase (p &lt; 0.001) was evident in serum of stage III/IV cancers compared to both adenomas and non-metastatic disease. MMP7 was increased in cancer tissues with prevalence in stage I/II. Lymph nodes presented a significant increase of MMP7 (p &lt; 0.05 adenoma vs. stage I/II and p &lt; 0.001 vs. stage III/IV). Conclusion: MMP7 increases with dysplasia and cancer disease stage in tumour tissue as well as in the regional lymph nodes. It may be used as a complement in investigating suspected locally advanced cancer.},
  author       = {Polistena, Andrea and Cucina, Alessandra and Dinicola, Simona and Stene, Christina and Cavallaro, Giuseppe and Ciardi, Antonio and Orlando, Gennaro and Arena, Rossella and D'Ermo, Giuseppe and Cavallaro, Antonino and Johnson, Louis Banka and De Toma, Giorgio},
  issn         = {0258-851X},
  keyword      = {Matrilysin,MMP7,colorectal cancer,adenoma,lymph nodes},
  language     = {eng},
  number       = {1},
  pages        = {105--110},
  publisher    = {In vivo},
  series       = {In Vivo},
  title        = {MMP7 Expression in Colorectal Tumours of Different Stages},
  volume       = {28},
  year         = {2014},
}