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Synthesis of podoscyphic acid

Eriksson Bajtner, Johan LU ; Johansson, Martin H LU and Sterner, Olov LU (2002) In Tetrahedron Letters 43(5). p.891-893
Abstract
Podoscyphic acid 1, a fungal metabolite inhibiting RNA-directed DNA polymerises, was synthesised in four steps starting from dodecanal. The concluding ester hydrolysis of 4 was not feasible with chemical reagents, only enzymatic hydrolysis was mild enough to release the highly reactive natural product in good yields. (C) 2002 Elsevier Science Ltd. All rights reserved.
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
enzymatic hydrolysis, podoscyphic acid, synthesis lipase
in
Tetrahedron Letters
volume
43
issue
5
pages
891 - 893
publisher
Elsevier
external identifiers
  • wos:000173596400038
  • scopus:0037185505
ISSN
0040-4039
DOI
10.1016/S0040-4039(01)02264-X
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
id
4319199c-a88a-4849-99cb-cfab4b750ba8 (old id 344033)
date added to LUP
2016-04-01 15:51:26
date last changed
2022-01-28 07:33:20
@article{4319199c-a88a-4849-99cb-cfab4b750ba8,
  abstract     = {{Podoscyphic acid 1, a fungal metabolite inhibiting RNA-directed DNA polymerises, was synthesised in four steps starting from dodecanal. The concluding ester hydrolysis of 4 was not feasible with chemical reagents, only enzymatic hydrolysis was mild enough to release the highly reactive natural product in good yields. (C) 2002 Elsevier Science Ltd. All rights reserved.}},
  author       = {{Eriksson Bajtner, Johan and Johansson, Martin H and Sterner, Olov}},
  issn         = {{0040-4039}},
  keywords     = {{enzymatic hydrolysis; podoscyphic acid; synthesis lipase}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{891--893}},
  publisher    = {{Elsevier}},
  series       = {{Tetrahedron Letters}},
  title        = {{Synthesis of podoscyphic acid}},
  url          = {{http://dx.doi.org/10.1016/S0040-4039(01)02264-X}},
  doi          = {{10.1016/S0040-4039(01)02264-X}},
  volume       = {{43}},
  year         = {{2002}},
}