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Comparative sequence analysis of the non-protein-coding mitochondrial DNA of inbred rat strains.

Abhyankar, Avinash LU ; Park, Hee-Bok LU ; Tonolo, Giancarlo LU and Luthman, Holger LU (2009) In PLoS ONE 4(12).
Abstract
The proper function of mammalian mitochondria necessitates a coordinated expression of both nuclear and mitochondrial genes, most likely due to the co-evolution of nuclear and mitochondrial genomes. The non-protein coding regions of mitochondrial DNA (mtDNA) including the D-loop, tRNA and rRNA genes form a major component of this regulated expression unit. Here we present comparative analyses of the non-protein-coding regions from 27 Rattus norvegicus mtDNA sequences. There were two variable positions in 12S rRNA, 20 in 16S rRNA, eight within the tRNA genes and 13 in the D-loop. Only one of the three neutrality tests used demonstrated statistically significant evidence for selection in 16S rRNA and tRNA-Cys. Based on our analyses of... (More)
The proper function of mammalian mitochondria necessitates a coordinated expression of both nuclear and mitochondrial genes, most likely due to the co-evolution of nuclear and mitochondrial genomes. The non-protein coding regions of mitochondrial DNA (mtDNA) including the D-loop, tRNA and rRNA genes form a major component of this regulated expression unit. Here we present comparative analyses of the non-protein-coding regions from 27 Rattus norvegicus mtDNA sequences. There were two variable positions in 12S rRNA, 20 in 16S rRNA, eight within the tRNA genes and 13 in the D-loop. Only one of the three neutrality tests used demonstrated statistically significant evidence for selection in 16S rRNA and tRNA-Cys. Based on our analyses of conserved sequences, we propose that some of the variable nucleotide positions identified in 16S rRNA and tRNA-Cys, and the D-loop might be important for mitochondrial function and its regulation. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
4
issue
12
article number
e8148
publisher
Public Library of Science (PLoS)
external identifiers
  • wos:000272829500010
  • pmid:19997590
  • scopus:77949539305
ISSN
1932-6203
DOI
10.1371/journal.pone.0008148
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Genetics Unit (013241550), Pediatrics/Urology/Gynecology/Endocrinology (013240400)
id
4324cb97-11ba-45af-8a6e-3300b47c52e8 (old id 1523736)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19997590?dopt=Abstract
date added to LUP
2016-04-04 09:29:17
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2022-02-06 03:12:49
@article{4324cb97-11ba-45af-8a6e-3300b47c52e8,
  abstract     = {{The proper function of mammalian mitochondria necessitates a coordinated expression of both nuclear and mitochondrial genes, most likely due to the co-evolution of nuclear and mitochondrial genomes. The non-protein coding regions of mitochondrial DNA (mtDNA) including the D-loop, tRNA and rRNA genes form a major component of this regulated expression unit. Here we present comparative analyses of the non-protein-coding regions from 27 Rattus norvegicus mtDNA sequences. There were two variable positions in 12S rRNA, 20 in 16S rRNA, eight within the tRNA genes and 13 in the D-loop. Only one of the three neutrality tests used demonstrated statistically significant evidence for selection in 16S rRNA and tRNA-Cys. Based on our analyses of conserved sequences, we propose that some of the variable nucleotide positions identified in 16S rRNA and tRNA-Cys, and the D-loop might be important for mitochondrial function and its regulation.}},
  author       = {{Abhyankar, Avinash and Park, Hee-Bok and Tonolo, Giancarlo and Luthman, Holger}},
  issn         = {{1932-6203}},
  language     = {{eng}},
  number       = {{12}},
  publisher    = {{Public Library of Science (PLoS)}},
  series       = {{PLoS ONE}},
  title        = {{Comparative sequence analysis of the non-protein-coding mitochondrial DNA of inbred rat strains.}},
  url          = {{https://lup.lub.lu.se/search/files/5337907/1530449.pdf}},
  doi          = {{10.1371/journal.pone.0008148}},
  volume       = {{4}},
  year         = {{2009}},
}