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Enhanced levels of immunoreactive beta-casomorphin-8 in milk of breastfeeding women with mastitis

Righard, Lennart LU ; Carlsson-Jonsson, Anna and Nyberg, Fred (2014) In Peptides 51. p.54-58
Abstract
An incorrect, superficial suckling technique in breastfeeding frequently leads to milk congestion and sometimes mastitis. In the present study we have examined whether milk congestion may affect levels of the atypical opioid beta-casomorphin-8 in milk and in plasma. We also investigated whether the rate of acute psychosis during the first half year after parturition has declined in Sweden over the years. Milk and plasma samples were collected for peptide analysis from 14 women with mastitis and 10 controls. We found that in a group of 14 late cases of mastitis (median 48 days post partum) the detected mean level of beta-casomorphin-8 in milk was significantly higher and somewhat higher in plasma at the acute stage compared with 2-3 weeks... (More)
An incorrect, superficial suckling technique in breastfeeding frequently leads to milk congestion and sometimes mastitis. In the present study we have examined whether milk congestion may affect levels of the atypical opioid beta-casomorphin-8 in milk and in plasma. We also investigated whether the rate of acute psychosis during the first half year after parturition has declined in Sweden over the years. Milk and plasma samples were collected for peptide analysis from 14 women with mastitis and 10 controls. We found that in a group of 14 late cases of mastitis (median 48 days post partum) the detected mean level of beta-casomorphin-8 in milk was significantly higher and somewhat higher in plasma at the acute stage compared with 2-3 weeks later, after recovery when the symptoms had disappeared, as well as compared to the control subjects. Swedish official statistics show that the incidence of acute psychosis in the first month and in the first half year after birth has declined by a half during the last 30 years. A relationship between postpartum psychosis and elevated beta-casomorphin-8 levels in CSF has been suggested from earlier studies. In this study, milk congestion led to enhanced levels of beta-casomorphin-8 in milk, which may be related to postpartum psychosis and probably also to the postnatal blues'. (C) 2013 Elsevier Inc. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Atypical opioids, beta-Casomorphins, Lactation, Radioimmunoassay, Mastitis, Postpartum psychosis
in
Peptides
volume
51
pages
54 - 58
publisher
Elsevier
external identifiers
  • wos:000329208100009
  • scopus:84888145070
ISSN
1873-5169
DOI
10.1016/j.peptides.2013.10.027
language
English
LU publication?
yes
id
fb4436ee-88ec-45b0-952c-0523dd0d31d4 (old id 4327123)
date added to LUP
2014-03-03 07:56:02
date last changed
2017-01-01 04:02:53
@article{fb4436ee-88ec-45b0-952c-0523dd0d31d4,
  abstract     = {An incorrect, superficial suckling technique in breastfeeding frequently leads to milk congestion and sometimes mastitis. In the present study we have examined whether milk congestion may affect levels of the atypical opioid beta-casomorphin-8 in milk and in plasma. We also investigated whether the rate of acute psychosis during the first half year after parturition has declined in Sweden over the years. Milk and plasma samples were collected for peptide analysis from 14 women with mastitis and 10 controls. We found that in a group of 14 late cases of mastitis (median 48 days post partum) the detected mean level of beta-casomorphin-8 in milk was significantly higher and somewhat higher in plasma at the acute stage compared with 2-3 weeks later, after recovery when the symptoms had disappeared, as well as compared to the control subjects. Swedish official statistics show that the incidence of acute psychosis in the first month and in the first half year after birth has declined by a half during the last 30 years. A relationship between postpartum psychosis and elevated beta-casomorphin-8 levels in CSF has been suggested from earlier studies. In this study, milk congestion led to enhanced levels of beta-casomorphin-8 in milk, which may be related to postpartum psychosis and probably also to the postnatal blues'. (C) 2013 Elsevier Inc. All rights reserved.},
  author       = {Righard, Lennart and Carlsson-Jonsson, Anna and Nyberg, Fred},
  issn         = {1873-5169},
  keyword      = {Atypical opioids,beta-Casomorphins,Lactation,Radioimmunoassay,Mastitis,Postpartum psychosis},
  language     = {eng},
  pages        = {54--58},
  publisher    = {Elsevier},
  series       = {Peptides},
  title        = {Enhanced levels of immunoreactive beta-casomorphin-8 in milk of breastfeeding women with mastitis},
  url          = {http://dx.doi.org/10.1016/j.peptides.2013.10.027},
  volume       = {51},
  year         = {2014},
}