Increasing preoperative body size in breast cancer patients between 2002 and 2016 : implications for prognosis
(2018) In Cancer Causes and Control 29(7). p.643-656- Abstract
Overweight and obesity are increasing worldwide, but the extent in breast cancer patients is unknown. The two aims were to study secular trends in preoperative body mass index (BMI), waist circumference, and breast volume and their impacts on clinical outcome. BMI, waist circumference, and breast volume were measured preoperatively in 24–99-year-old primary breast cancer patients (n = 640) in Sweden 2002–2016. The measurements were analyzed alone and combined in relation to recurrence and overall survival (OS). BMI, waist circumference, and breast volume increased 2002–2016 (ptrends < 0.0001). Of these, a breast volume ≥ 850 mL was associated with the strongest recurrence-risk (adjusted hazard ratio [adjHR]... (More)
Overweight and obesity are increasing worldwide, but the extent in breast cancer patients is unknown. The two aims were to study secular trends in preoperative body mass index (BMI), waist circumference, and breast volume and their impacts on clinical outcome. BMI, waist circumference, and breast volume were measured preoperatively in 24–99-year-old primary breast cancer patients (n = 640) in Sweden 2002–2016. The measurements were analyzed alone and combined in relation to recurrence and overall survival (OS). BMI, waist circumference, and breast volume increased 2002–2016 (ptrends < 0.0001). Of these, a breast volume ≥ 850 mL was associated with the strongest recurrence-risk (adjusted hazard ratio [adjHR] 1.67; 95% CI 1.17–2.39), especially combined with waist circumference ≥ 80 cm (adjHR 2.07; 95% CI 1.25–3.44), while BMI ≥ 25 kg/m2 or large waist circumference conferred almost a twofold risk for death (both Log-Rank p ≤ 0.0001). Chemotherapy seemed to counteract the negative impact of a high BMI or large waist circumference on OS. Large breast volume was the strongest predictor for recurrence in all treatment groups. In conclusion, preoperative BMI, waist circumference, and breast volume increased between 2002 and 2016. Larger body size negatively impacted breast cancer-free interval and OS. If confirmed, body measurements may help select patients requiring more individualized treatment.
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- author
- Wisse, Agatha ; Tryggvadottir, Helga LU ; Simonsson, Maria LU ; Isaksson, Karolin LU ; Rose, Carsten LU ; Ingvar, Christian LU and Jernström, Helena LU
- organization
- publishing date
- 2018-07
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Body mass index, Breast cancer, Breast volume, Changes over time, Prognosis, Waist circumference
- in
- Cancer Causes and Control
- volume
- 29
- issue
- 7
- pages
- 643 - 656
- publisher
- Springer
- external identifiers
-
- pmid:29804217
- scopus:85047404046
- ISSN
- 0957-5243
- DOI
- 10.1007/s10552-018-1042-z
- language
- English
- LU publication?
- yes
- id
- 432f9c25-94d5-4e7e-a009-e01f05b3e320
- date added to LUP
- 2018-06-05 11:03:28
- date last changed
- 2024-09-17 21:58:45
@article{432f9c25-94d5-4e7e-a009-e01f05b3e320, abstract = {{<p>Overweight and obesity are increasing worldwide, but the extent in breast cancer patients is unknown. The two aims were to study secular trends in preoperative body mass index (BMI), waist circumference, and breast volume and their impacts on clinical outcome. BMI, waist circumference, and breast volume were measured preoperatively in 24–99-year-old primary breast cancer patients (n = 640) in Sweden 2002–2016. The measurements were analyzed alone and combined in relation to recurrence and overall survival (OS). BMI, waist circumference, and breast volume increased 2002–2016 (p<sub>trends</sub> < 0.0001). Of these, a breast volume ≥ 850 mL was associated with the strongest recurrence-risk (adjusted hazard ratio [<sub>adj</sub>HR] 1.67; 95% CI 1.17–2.39), especially combined with waist circumference ≥ 80 cm (<sub>adj</sub>HR 2.07; 95% CI 1.25–3.44), while BMI ≥ 25 kg/m<sup>2</sup> or large waist circumference conferred almost a twofold risk for death (both Log-Rank p ≤ 0.0001). Chemotherapy seemed to counteract the negative impact of a high BMI or large waist circumference on OS. Large breast volume was the strongest predictor for recurrence in all treatment groups. In conclusion, preoperative BMI, waist circumference, and breast volume increased between 2002 and 2016. Larger body size negatively impacted breast cancer-free interval and OS. If confirmed, body measurements may help select patients requiring more individualized treatment.</p>}}, author = {{Wisse, Agatha and Tryggvadottir, Helga and Simonsson, Maria and Isaksson, Karolin and Rose, Carsten and Ingvar, Christian and Jernström, Helena}}, issn = {{0957-5243}}, keywords = {{Body mass index; Breast cancer; Breast volume; Changes over time; Prognosis; Waist circumference}}, language = {{eng}}, number = {{7}}, pages = {{643--656}}, publisher = {{Springer}}, series = {{Cancer Causes and Control}}, title = {{Increasing preoperative body size in breast cancer patients between 2002 and 2016 : implications for prognosis}}, url = {{http://dx.doi.org/10.1007/s10552-018-1042-z}}, doi = {{10.1007/s10552-018-1042-z}}, volume = {{29}}, year = {{2018}}, }