Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Increasing preoperative body size in breast cancer patients between 2002 and 2016 : implications for prognosis

Wisse, Agatha ; Tryggvadottir, Helga LU ; Simonsson, Maria LU ; Isaksson, Karolin LU ; Rose, Carsten LU ; Ingvar, Christian LU and Jernström, Helena LU (2018) In Cancer Causes and Control 29(7). p.643-656
Abstract

Overweight and obesity are increasing worldwide, but the extent in breast cancer patients is unknown. The two aims were to study secular trends in preoperative body mass index (BMI), waist circumference, and breast volume and their impacts on clinical outcome. BMI, waist circumference, and breast volume were measured preoperatively in 24–99-year-old primary breast cancer patients (n = 640) in Sweden 2002–2016. The measurements were analyzed alone and combined in relation to recurrence and overall survival (OS). BMI, waist circumference, and breast volume increased 2002–2016 (ptrends < 0.0001). Of these, a breast volume ≥ 850 mL was associated with the strongest recurrence-risk (adjusted hazard ratio [adjHR]... (More)

Overweight and obesity are increasing worldwide, but the extent in breast cancer patients is unknown. The two aims were to study secular trends in preoperative body mass index (BMI), waist circumference, and breast volume and their impacts on clinical outcome. BMI, waist circumference, and breast volume were measured preoperatively in 24–99-year-old primary breast cancer patients (n = 640) in Sweden 2002–2016. The measurements were analyzed alone and combined in relation to recurrence and overall survival (OS). BMI, waist circumference, and breast volume increased 2002–2016 (ptrends < 0.0001). Of these, a breast volume ≥ 850 mL was associated with the strongest recurrence-risk (adjusted hazard ratio [adjHR] 1.67; 95% CI 1.17–2.39), especially combined with waist circumference ≥ 80 cm (adjHR 2.07; 95% CI 1.25–3.44), while BMI ≥ 25 kg/m2 or large waist circumference conferred almost a twofold risk for death (both Log-Rank p ≤ 0.0001). Chemotherapy seemed to counteract the negative impact of a high BMI or large waist circumference on OS. Large breast volume was the strongest predictor for recurrence in all treatment groups. In conclusion, preoperative BMI, waist circumference, and breast volume increased between 2002 and 2016. Larger body size negatively impacted breast cancer-free interval and OS. If confirmed, body measurements may help select patients requiring more individualized treatment.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Body mass index, Breast cancer, Breast volume, Changes over time, Prognosis, Waist circumference
in
Cancer Causes and Control
volume
29
issue
7
pages
643 - 656
publisher
Springer
external identifiers
  • scopus:85047404046
  • pmid:29804217
ISSN
0957-5243
DOI
10.1007/s10552-018-1042-z
language
English
LU publication?
yes
id
432f9c25-94d5-4e7e-a009-e01f05b3e320
date added to LUP
2018-06-05 11:03:28
date last changed
2024-06-10 13:35:07
@article{432f9c25-94d5-4e7e-a009-e01f05b3e320,
  abstract     = {{<p>Overweight and obesity are increasing worldwide, but the extent in breast cancer patients is unknown. The two aims were to study secular trends in preoperative body mass index (BMI), waist circumference, and breast volume and their impacts on clinical outcome. BMI, waist circumference, and breast volume were measured preoperatively in 24–99-year-old primary breast cancer patients (n = 640) in Sweden 2002–2016. The measurements were analyzed alone and combined in relation to recurrence and overall survival (OS). BMI, waist circumference, and breast volume increased 2002–2016 (p<sub>trends</sub> &lt; 0.0001). Of these, a breast volume ≥ 850 mL was associated with the strongest recurrence-risk (adjusted hazard ratio [<sub>adj</sub>HR] 1.67; 95% CI 1.17–2.39), especially combined with waist circumference ≥ 80 cm (<sub>adj</sub>HR 2.07; 95% CI 1.25–3.44), while BMI ≥ 25 kg/m<sup>2</sup> or large waist circumference conferred almost a twofold risk for death (both Log-Rank p ≤ 0.0001). Chemotherapy seemed to counteract the negative impact of a high BMI or large waist circumference on OS. Large breast volume was the strongest predictor for recurrence in all treatment groups. In conclusion, preoperative BMI, waist circumference, and breast volume increased between 2002 and 2016. Larger body size negatively impacted breast cancer-free interval and OS. If confirmed, body measurements may help select patients requiring more individualized treatment.</p>}},
  author       = {{Wisse, Agatha and Tryggvadottir, Helga and Simonsson, Maria and Isaksson, Karolin and Rose, Carsten and Ingvar, Christian and Jernström, Helena}},
  issn         = {{0957-5243}},
  keywords     = {{Body mass index; Breast cancer; Breast volume; Changes over time; Prognosis; Waist circumference}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{643--656}},
  publisher    = {{Springer}},
  series       = {{Cancer Causes and Control}},
  title        = {{Increasing preoperative body size in breast cancer patients between 2002 and 2016 : implications for prognosis}},
  url          = {{http://dx.doi.org/10.1007/s10552-018-1042-z}},
  doi          = {{10.1007/s10552-018-1042-z}},
  volume       = {{29}},
  year         = {{2018}},
}