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Cysteinyl leukotrienes and their receptors: Bridging inflammation and colorectal cancer.

Savari, Sayeh LU ; Vinnakota, Katyayni LU ; Zhang, Yuan LU and Sjölander, Anita LU (2014) In World Journal of Gastroenterology 20(4). p.968-977
Abstract
Long-standing inflammation has emerged as a hallmark of neoplastic transformation of epithelial cells and may be a limiting factor of successful conventional tumor therapies. A complex milieu composed of distinct stromal and immune cells, soluble factors and inflammatory mediators plays a crucial role in supporting and promoting various types of cancers. An augmented inflammatory response can predispose a patient to colorectal cancer (CRC). Common risk factors associated with CRC development include diet and lifestyle, altered intestinal microbiota and commensals, and chronic inflammatory bowel diseases. Cysteinyl leukotrienes are potent inflammatory metabolites synthesized from arachidonic acid and have a broad range of functions involved... (More)
Long-standing inflammation has emerged as a hallmark of neoplastic transformation of epithelial cells and may be a limiting factor of successful conventional tumor therapies. A complex milieu composed of distinct stromal and immune cells, soluble factors and inflammatory mediators plays a crucial role in supporting and promoting various types of cancers. An augmented inflammatory response can predispose a patient to colorectal cancer (CRC). Common risk factors associated with CRC development include diet and lifestyle, altered intestinal microbiota and commensals, and chronic inflammatory bowel diseases. Cysteinyl leukotrienes are potent inflammatory metabolites synthesized from arachidonic acid and have a broad range of functions involved in the etiology of various pathologies. This review discusses the important role of cysteinyl leukotriene signaling in linking inflammation and CRC. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
World Journal of Gastroenterology
volume
20
issue
4
pages
968 - 977
publisher
WJG Press
external identifiers
  • pmid:24574769
  • wos:000330856700009
  • scopus:84892979085
ISSN
1007-9327
DOI
10.3748/wjg.v20.i4.968
language
English
LU publication?
yes
id
de9f82db-9eb5-4e2d-9325-3888f59c9f6a (old id 4333875)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24574769?dopt=Abstract
date added to LUP
2014-03-05 17:51:01
date last changed
2017-09-03 03:00:46
@article{de9f82db-9eb5-4e2d-9325-3888f59c9f6a,
  abstract     = {Long-standing inflammation has emerged as a hallmark of neoplastic transformation of epithelial cells and may be a limiting factor of successful conventional tumor therapies. A complex milieu composed of distinct stromal and immune cells, soluble factors and inflammatory mediators plays a crucial role in supporting and promoting various types of cancers. An augmented inflammatory response can predispose a patient to colorectal cancer (CRC). Common risk factors associated with CRC development include diet and lifestyle, altered intestinal microbiota and commensals, and chronic inflammatory bowel diseases. Cysteinyl leukotrienes are potent inflammatory metabolites synthesized from arachidonic acid and have a broad range of functions involved in the etiology of various pathologies. This review discusses the important role of cysteinyl leukotriene signaling in linking inflammation and CRC.},
  author       = {Savari, Sayeh and Vinnakota, Katyayni and Zhang, Yuan and Sjölander, Anita},
  issn         = {1007-9327},
  language     = {eng},
  number       = {4},
  pages        = {968--977},
  publisher    = {WJG Press},
  series       = {World Journal of Gastroenterology},
  title        = {Cysteinyl leukotrienes and their receptors: Bridging inflammation and colorectal cancer.},
  url          = {http://dx.doi.org/10.3748/wjg.v20.i4.968},
  volume       = {20},
  year         = {2014},
}