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Use of wall-less (18)F-doped gelatin phantoms for improved volume delineation and quantification in PET/CT.

Sydoff, Marie LU ; Andersson, Martin LU ; Mattsson, Sören LU and Leide Svegborn, Sigrid LU (2014) In Physics in Medicine and Biology 59(5). p.1097-1107
Abstract
Positron emission tomography (PET) with (18)F-FDG is a valuable tool for staging, planning treatment, and evaluating the treatment response for many different types of tumours. The correct volume estimation is of utmost importance in these situations. To date, the most common types of phantoms used in volume quantification in PET utilize fillable, hollow spheres placed in a circular or elliptical cylinder made of polymethyl methacrylate. However, the presence of a non-radioactive sphere wall between the hotspot and the background activity in images of this type of phantom could cause inaccuracies. To investigate the influence of the non-active walls, we developed a phantom without non-active sphere walls for volume delineation and... (More)
Positron emission tomography (PET) with (18)F-FDG is a valuable tool for staging, planning treatment, and evaluating the treatment response for many different types of tumours. The correct volume estimation is of utmost importance in these situations. To date, the most common types of phantoms used in volume quantification in PET utilize fillable, hollow spheres placed in a circular or elliptical cylinder made of polymethyl methacrylate. However, the presence of a non-radioactive sphere wall between the hotspot and the background activity in images of this type of phantom could cause inaccuracies. To investigate the influence of the non-active walls, we developed a phantom without non-active sphere walls for volume delineation and quantification in PET. Three sizes of gelatin hotspots were moulded and placed in a Jaszczak phantom together with hollow plastic spheres of the same sizes containing the same activity concentration. (18)F PET measurements were made with zero background activity and with tumour-to-background ratios of 12.5, 10, 7.5, and 5. The background-corrected volume reproducing threshold, Tvol, was calculated for both the gelatin and the plastic spheres. It was experimentally verified that the apparent background dependence of Tvol, i.e., a decreasing Tvol with increasing background fraction, was not present for wall-less spheres; the opposite results were seen in plastic, hollow spheres in commercially-available phantoms. For the types of phantoms commonly used in activity quantification, the estimation of Tvol using fillable, hollow, plastic spheres with non-active walls would lead to an overestimate of the tumour volume, especially for small volumes in a high activity background. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Physics in Medicine and Biology
volume
59
issue
5
pages
1097 - 1107
publisher
IOP Publishing
external identifiers
  • pmid:24556921
  • wos:000331950000002
  • scopus:84894541167
ISSN
1361-6560
DOI
10.1088/0031-9155/59/5/1097
language
English
LU publication?
yes
id
fb165357-c12f-4642-9255-75a77f4b5b91 (old id 4334332)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24556921?dopt=Abstract
date added to LUP
2014-03-05 20:54:27
date last changed
2017-07-30 03:21:46
@article{fb165357-c12f-4642-9255-75a77f4b5b91,
  abstract     = {Positron emission tomography (PET) with (18)F-FDG is a valuable tool for staging, planning treatment, and evaluating the treatment response for many different types of tumours. The correct volume estimation is of utmost importance in these situations. To date, the most common types of phantoms used in volume quantification in PET utilize fillable, hollow spheres placed in a circular or elliptical cylinder made of polymethyl methacrylate. However, the presence of a non-radioactive sphere wall between the hotspot and the background activity in images of this type of phantom could cause inaccuracies. To investigate the influence of the non-active walls, we developed a phantom without non-active sphere walls for volume delineation and quantification in PET. Three sizes of gelatin hotspots were moulded and placed in a Jaszczak phantom together with hollow plastic spheres of the same sizes containing the same activity concentration. (18)F PET measurements were made with zero background activity and with tumour-to-background ratios of 12.5, 10, 7.5, and 5. The background-corrected volume reproducing threshold, Tvol, was calculated for both the gelatin and the plastic spheres. It was experimentally verified that the apparent background dependence of Tvol, i.e., a decreasing Tvol with increasing background fraction, was not present for wall-less spheres; the opposite results were seen in plastic, hollow spheres in commercially-available phantoms. For the types of phantoms commonly used in activity quantification, the estimation of Tvol using fillable, hollow, plastic spheres with non-active walls would lead to an overestimate of the tumour volume, especially for small volumes in a high activity background.},
  author       = {Sydoff, Marie and Andersson, Martin and Mattsson, Sören and Leide Svegborn, Sigrid},
  issn         = {1361-6560},
  language     = {eng},
  number       = {5},
  pages        = {1097--1107},
  publisher    = {IOP Publishing},
  series       = {Physics in Medicine and Biology},
  title        = {Use of wall-less (18)F-doped gelatin phantoms for improved volume delineation and quantification in PET/CT.},
  url          = {http://dx.doi.org/10.1088/0031-9155/59/5/1097},
  volume       = {59},
  year         = {2014},
}