EndoS Reduces the Pathogenicity of Anti-mCOL7 IgG through Reduced Binding of Immune Complexes to Neutrophils.
Yu, Xinhua ; Zheng, Junfeng ; Collin, Mattias LU
; Schmidt, Enno
; Zillikens, Detlef
and Petersen, Frank
(2014)
In PLoS ONE
9(2).
- Abstract
- Endo-β-N-acetylglucosaminidase (EndoS) has been shown to act as a potent pathogen-derived immunomodulatory molecule in autoimmune diseases. Here we investigated how EndoS treatment reduces the pathogenicity of rabbit anti-mCOL7 IgG using different experimental models of epidermolysis bullosa acquisita (EBA). Our results show that the EndoS treatment does not interfere with the binding of the antibody to the antigen but reduces immune complex (IC)-mediated neutrophil activation by impairing the binding of the IC to FcγR on neutrophils. On the basis of this newly identified EndoS-mediated mechanism we hope to develop new strategies in the treatment of the disease.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4335435
- author
- Yu, Xinhua
; Zheng, Junfeng
; Collin, Mattias
LU
; Schmidt, Enno
; Zillikens, Detlef
and Petersen, Frank
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 9
- issue
- 2
- article number
- e85317
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- pmid:24504190
- wos:000330631800005
- scopus:84896866511
- pmid:24504190
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0085317
- language
- English
- LU publication?
- yes
- id
- 12556fa1-78fd-42d1-912b-bf3339e22118 (old id 4335435)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24504190?dopt=Abstract
- date added to LUP
- 2016-04-01 13:29:42
- date last changed
- 2022-03-14 00:19:32
@article{12556fa1-78fd-42d1-912b-bf3339e22118,
abstract = {{Endo-β-N-acetylglucosaminidase (EndoS) has been shown to act as a potent pathogen-derived immunomodulatory molecule in autoimmune diseases. Here we investigated how EndoS treatment reduces the pathogenicity of rabbit anti-mCOL7 IgG using different experimental models of epidermolysis bullosa acquisita (EBA). Our results show that the EndoS treatment does not interfere with the binding of the antibody to the antigen but reduces immune complex (IC)-mediated neutrophil activation by impairing the binding of the IC to FcγR on neutrophils. On the basis of this newly identified EndoS-mediated mechanism we hope to develop new strategies in the treatment of the disease.}},
author = {{Yu, Xinhua and Zheng, Junfeng and Collin, Mattias and Schmidt, Enno and Zillikens, Detlef and Petersen, Frank}},
issn = {{1932-6203}},
language = {{eng}},
number = {{2}},
publisher = {{Public Library of Science (PLoS)}},
series = {{PLoS ONE}},
title = {{EndoS Reduces the Pathogenicity of Anti-mCOL7 IgG through Reduced Binding of Immune Complexes to Neutrophils.}},
url = {{https://lup.lub.lu.se/search/files/3402458/4779561.pdf}},
doi = {{10.1371/journal.pone.0085317}},
volume = {{9}},
year = {{2014}},
}