Optimizing retention of multimodal imaging nanostructures in sentinel lymph nodes by nanoscale size tailoring.
(2014) In Nanomedicine: Nanotechnology, Biology and Medicine 10(5). p.1089-1095- Abstract
- This study investigates the retention of different sized ultra-small superparamagnetic iron oxide nanoparticles (USPIOs) in lymph nodes of healthy rats, after subcutaneous injection. Three distinct sizes (15, 27 and 58 nm) of USPIOs were synthesized by only varying the thickness of the polymer coating surrounding the 10 nm cores. Particles were injected on the dorsal side of the hind paw of rats and the uptake in the popliteal, inguinal and iliac lymph nodes was monitored. The data reveal that the 15 nm particle accumulates more rapidly and to a higher amount in the first lymph node than the two larger particles. A clear contrast between the first and second lymph nodes could be detected indicating that even the rather small difference in... (More)
- This study investigates the retention of different sized ultra-small superparamagnetic iron oxide nanoparticles (USPIOs) in lymph nodes of healthy rats, after subcutaneous injection. Three distinct sizes (15, 27 and 58 nm) of USPIOs were synthesized by only varying the thickness of the polymer coating surrounding the 10 nm cores. Particles were injected on the dorsal side of the hind paw of rats and the uptake in the popliteal, inguinal and iliac lymph nodes was monitored. The data reveal that the 15 nm particle accumulates more rapidly and to a higher amount in the first lymph node than the two larger particles. A clear contrast between the first and second lymph nodes could be detected indicating that even the rather small difference in particle size (15-58 nm) tested has significant effects on the retention of USPIOs in the lymph nodes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4335453
- author
- Kjellman, Pontus
LU
; in 't Zandt, René
LU
; Fredriksson, Sarah and Strand, Sven-Erik LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nanomedicine: Nanotechnology, Biology and Medicine
- volume
- 10
- issue
- 5
- pages
- 1089 - 1095
- publisher
- Elsevier
- external identifiers
-
- pmid:24502988
- wos:000338736200021
- scopus:84903537010
- pmid:24502988
- ISSN
- 1549-9642
- DOI
- 10.1016/j.nano.2014.01.007
- language
- English
- LU publication?
- yes
- id
- 6375965e-fd9c-4492-a2e2-09b56f752ecb (old id 4335453)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24502988?dopt=Abstract
- date added to LUP
- 2016-04-01 10:23:32
- date last changed
- 2022-08-12 19:26:38
@article{6375965e-fd9c-4492-a2e2-09b56f752ecb, abstract = {{This study investigates the retention of different sized ultra-small superparamagnetic iron oxide nanoparticles (USPIOs) in lymph nodes of healthy rats, after subcutaneous injection. Three distinct sizes (15, 27 and 58 nm) of USPIOs were synthesized by only varying the thickness of the polymer coating surrounding the 10 nm cores. Particles were injected on the dorsal side of the hind paw of rats and the uptake in the popliteal, inguinal and iliac lymph nodes was monitored. The data reveal that the 15 nm particle accumulates more rapidly and to a higher amount in the first lymph node than the two larger particles. A clear contrast between the first and second lymph nodes could be detected indicating that even the rather small difference in particle size (15-58 nm) tested has significant effects on the retention of USPIOs in the lymph nodes.}}, author = {{Kjellman, Pontus and in 't Zandt, René and Fredriksson, Sarah and Strand, Sven-Erik}}, issn = {{1549-9642}}, language = {{eng}}, number = {{5}}, pages = {{1089--1095}}, publisher = {{Elsevier}}, series = {{Nanomedicine: Nanotechnology, Biology and Medicine}}, title = {{Optimizing retention of multimodal imaging nanostructures in sentinel lymph nodes by nanoscale size tailoring.}}, url = {{http://dx.doi.org/10.1016/j.nano.2014.01.007}}, doi = {{10.1016/j.nano.2014.01.007}}, volume = {{10}}, year = {{2014}}, }