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Optimizing retention of multimodal imaging nanostructures in sentinel lymph nodes by nanoscale size tailoring.

Kjellman, Pontus LU ; in 't Zandt, René LU ; Fredriksson, Sarah and Strand, Sven-Erik LU (2014) In Nanomedicine: Nanotechnology, Biology and Medicine 10(5). p.1089-1095
Abstract
This study investigates the retention of different sized ultra-small superparamagnetic iron oxide nanoparticles (USPIOs) in lymph nodes of healthy rats, after subcutaneous injection. Three distinct sizes (15, 27 and 58 nm) of USPIOs were synthesized by only varying the thickness of the polymer coating surrounding the 10 nm cores. Particles were injected on the dorsal side of the hind paw of rats and the uptake in the popliteal, inguinal and iliac lymph nodes was monitored. The data reveal that the 15 nm particle accumulates more rapidly and to a higher amount in the first lymph node than the two larger particles. A clear contrast between the first and second lymph nodes could be detected indicating that even the rather small difference in... (More)
This study investigates the retention of different sized ultra-small superparamagnetic iron oxide nanoparticles (USPIOs) in lymph nodes of healthy rats, after subcutaneous injection. Three distinct sizes (15, 27 and 58 nm) of USPIOs were synthesized by only varying the thickness of the polymer coating surrounding the 10 nm cores. Particles were injected on the dorsal side of the hind paw of rats and the uptake in the popliteal, inguinal and iliac lymph nodes was monitored. The data reveal that the 15 nm particle accumulates more rapidly and to a higher amount in the first lymph node than the two larger particles. A clear contrast between the first and second lymph nodes could be detected indicating that even the rather small difference in particle size (15-58 nm) tested has significant effects on the retention of USPIOs in the lymph nodes. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Nanomedicine: Nanotechnology, Biology and Medicine
volume
10
issue
5
pages
1089 - 1095
publisher
Elsevier
external identifiers
  • pmid:24502988
  • wos:000338736200021
  • scopus:84903537010
ISSN
1549-9642
DOI
10.1016/j.nano.2014.01.007
language
English
LU publication?
yes
id
6375965e-fd9c-4492-a2e2-09b56f752ecb (old id 4335453)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24502988?dopt=Abstract
date added to LUP
2014-03-06 19:47:06
date last changed
2017-11-16 13:00:50
@article{6375965e-fd9c-4492-a2e2-09b56f752ecb,
  abstract     = {This study investigates the retention of different sized ultra-small superparamagnetic iron oxide nanoparticles (USPIOs) in lymph nodes of healthy rats, after subcutaneous injection. Three distinct sizes (15, 27 and 58 nm) of USPIOs were synthesized by only varying the thickness of the polymer coating surrounding the 10 nm cores. Particles were injected on the dorsal side of the hind paw of rats and the uptake in the popliteal, inguinal and iliac lymph nodes was monitored. The data reveal that the 15 nm particle accumulates more rapidly and to a higher amount in the first lymph node than the two larger particles. A clear contrast between the first and second lymph nodes could be detected indicating that even the rather small difference in particle size (15-58 nm) tested has significant effects on the retention of USPIOs in the lymph nodes.},
  author       = {Kjellman, Pontus and in 't Zandt, René and Fredriksson, Sarah and Strand, Sven-Erik},
  issn         = {1549-9642},
  language     = {eng},
  number       = {5},
  pages        = {1089--1095},
  publisher    = {Elsevier},
  series       = {Nanomedicine: Nanotechnology, Biology and Medicine},
  title        = {Optimizing retention of multimodal imaging nanostructures in sentinel lymph nodes by nanoscale size tailoring.},
  url          = {http://dx.doi.org/10.1016/j.nano.2014.01.007},
  volume       = {10},
  year         = {2014},
}