The effect of mixing on the dispersibility of adhesive mixtures for inhalation. Comparison of high shear and Turbula mixers
(2024) In European Journal of Pharmaceutical Sciences 193.- Abstract
This study investigates the effect of different mixers and the applicability of the mixing energy (ME) concept to dry powder formulations for inhalation. With the aim to step-wise build and expand this concept, adhesive mixtures of 2 % budesonide and lactose carrier were investigated, both with 1 % magnesium stearate (MgSt) added in a ‘coating’ step, and without, the latter referred to as ‘naked’ formulations. For high shear mixed formulations, the fine particle fraction (FPF) was found to increase with increasing ME up to 60 % and thereafter decreased, using the Novolizer device. The data could be well fitted to the modeling equation, thus confirming the validity of the ME concept. The naked formulations displayed a linear decrease in... (More)
This study investigates the effect of different mixers and the applicability of the mixing energy (ME) concept to dry powder formulations for inhalation. With the aim to step-wise build and expand this concept, adhesive mixtures of 2 % budesonide and lactose carrier were investigated, both with 1 % magnesium stearate (MgSt) added in a ‘coating’ step, and without, the latter referred to as ‘naked’ formulations. For high shear mixed formulations, the fine particle fraction (FPF) was found to increase with increasing ME up to 60 % and thereafter decreased, using the Novolizer device. The data could be well fitted to the modeling equation, thus confirming the validity of the ME concept. The naked formulations displayed a linear decrease in FPF with increasing ME, again showing the validity of the ME concept. For Turbula mixed formulations, FPF increased with increased mixing time (and mixing energy) for all batches. The naked (binary) composition reached to higher FPF values than for high shear mixing and the formulation with MgSt reached to FPF values around 60 %, demonstrating that it is possible to achieve the same high drug dispersibility with the Turbula mixer as for high shear mixer. An equation for calculation of mixing energy in Turbula mixing was set up in an analogous way to the equation for high shear mixing, which enabled direct comparison between the two mixers.
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- author
- Thalberg, Kyrre LU ; Ivarsson, Love ; Svensson, Mårten ; Elfman, Peter ; Ohlsson, Ann ; Stuckel, Jackie and Lyberg, Ann-Marie
- organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adhesive mixture, Blending, Dispersibility, Fine particle fraction, High shear mixer, Inhalation, Mixing energy, Turbula
- in
- European Journal of Pharmaceutical Sciences
- volume
- 193
- article number
- 106679
- publisher
- Elsevier
- external identifiers
-
- pmid:38128841
- scopus:85180570344
- ISSN
- 0928-0987
- DOI
- 10.1016/j.ejps.2023.106679
- language
- English
- LU publication?
- yes
- id
- 4348617e-e1dd-4bfc-99fb-89cf0763746f
- date added to LUP
- 2024-02-12 11:10:48
- date last changed
- 2024-04-14 02:41:51
@article{4348617e-e1dd-4bfc-99fb-89cf0763746f,
abstract = {{<p>This study investigates the effect of different mixers and the applicability of the mixing energy (ME) concept to dry powder formulations for inhalation. With the aim to step-wise build and expand this concept, adhesive mixtures of 2 % budesonide and lactose carrier were investigated, both with 1 % magnesium stearate (MgSt) added in a ‘coating’ step, and without, the latter referred to as ‘naked’ formulations. For high shear mixed formulations, the fine particle fraction (FPF) was found to increase with increasing ME up to 60 % and thereafter decreased, using the Novolizer device. The data could be well fitted to the modeling equation, thus confirming the validity of the ME concept. The naked formulations displayed a linear decrease in FPF with increasing ME, again showing the validity of the ME concept. For Turbula mixed formulations, FPF increased with increased mixing time (and mixing energy) for all batches. The naked (binary) composition reached to higher FPF values than for high shear mixing and the formulation with MgSt reached to FPF values around 60 %, demonstrating that it is possible to achieve the same high drug dispersibility with the Turbula mixer as for high shear mixer. An equation for calculation of mixing energy in Turbula mixing was set up in an analogous way to the equation for high shear mixing, which enabled direct comparison between the two mixers.</p>}},
author = {{Thalberg, Kyrre and Ivarsson, Love and Svensson, Mårten and Elfman, Peter and Ohlsson, Ann and Stuckel, Jackie and Lyberg, Ann-Marie}},
issn = {{0928-0987}},
keywords = {{Adhesive mixture; Blending; Dispersibility; Fine particle fraction; High shear mixer; Inhalation; Mixing energy; Turbula}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{European Journal of Pharmaceutical Sciences}},
title = {{The effect of mixing on the dispersibility of adhesive mixtures for inhalation. Comparison of high shear and Turbula mixers}},
url = {{http://dx.doi.org/10.1016/j.ejps.2023.106679}},
doi = {{10.1016/j.ejps.2023.106679}},
volume = {{193}},
year = {{2024}},
}