Recent functional insights into the role of (p)ppGpp in bacterial physiology
(2015) In Nature Reviews Microbiology 13(5). p.298-309- Abstract
The alarmones guanosine tetraphosphate and guanosine pentaphosphate (collectively referred to as (p)ppGpp) are involved in regulating growth and several different stress responses in bacteria. In recent years, substantial progress has been made in our understanding of the molecular mechanisms of (p)ppGpp metabolism and (p)ppGpp-mediated regulation. In this Review, we summarize these recent insights, with a focus on the molecular mechanisms governing the activity of the RelA/SpoT homologue (RSH) proteins, which are key players that regulate the cellular levels of (p)ppGpp. We also discuss the structural basis of transcriptional regulation by (p)ppGpp and the role of (p)ppGpp in GTP metabolism and in the emergence of bacterial... (More)
The alarmones guanosine tetraphosphate and guanosine pentaphosphate (collectively referred to as (p)ppGpp) are involved in regulating growth and several different stress responses in bacteria. In recent years, substantial progress has been made in our understanding of the molecular mechanisms of (p)ppGpp metabolism and (p)ppGpp-mediated regulation. In this Review, we summarize these recent insights, with a focus on the molecular mechanisms governing the activity of the RelA/SpoT homologue (RSH) proteins, which are key players that regulate the cellular levels of (p)ppGpp. We also discuss the structural basis of transcriptional regulation by (p)ppGpp and the role of (p)ppGpp in GTP metabolism and in the emergence of bacterial persisters.
(Less)
- author
- Hauryliuk, Vasili
LU
; Atkinson, Gemma C. LU ; Murakami, Katsuhiko S. ; Tenson, Tanel and Gerdes, Kenn
- publishing date
- 2015-05-24
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Reviews Microbiology
- volume
- 13
- issue
- 5
- pages
- 12 pages
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:84928435794
- pmid:25853779
- ISSN
- 1740-1526
- DOI
- 10.1038/nrmicro3448
- language
- English
- LU publication?
- no
- additional info
- Funding Information: The authors are grateful to V. Shingler for her comments on the manuscript and M. Valle for providing the cryo‑EM images of RelA. This work was supported by the European Regional Development Fund through the Centre of Excellence in Chemical Biology (V.H. and T.T.); by the Estonian Science Foundation (grants ETF9012 and PUT37 (V.H.), and grant ETF9020 (G.C.A.)); by Umeå University, the Swedish Research Council, the Ragnar Söderberg Foundation and the Kempe Foundation (V.H.); by the US National Institutes of Health (grant GM087350 (K.S.M.)); and by a European Research Council Advanced Investigator Grant (294517; PERSIST) and a Novo Nordisk Foundation Laureate Research Grant (K.G.). Publisher Copyright: © 2015 Macmillan Publishers Limited. All rights reserved. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.
- id
- 434d5a19-67e2-4d8b-bde5-548054fc4364
- date added to LUP
- 2021-09-24 20:43:08
- date last changed
- 2024-06-30 20:25:09
@article{434d5a19-67e2-4d8b-bde5-548054fc4364, abstract = {{<p>The alarmones guanosine tetraphosphate and guanosine pentaphosphate (collectively referred to as (p)ppGpp) are involved in regulating growth and several different stress responses in bacteria. In recent years, substantial progress has been made in our understanding of the molecular mechanisms of (p)ppGpp metabolism and (p)ppGpp-mediated regulation. In this Review, we summarize these recent insights, with a focus on the molecular mechanisms governing the activity of the RelA/SpoT homologue (RSH) proteins, which are key players that regulate the cellular levels of (p)ppGpp. We also discuss the structural basis of transcriptional regulation by (p)ppGpp and the role of (p)ppGpp in GTP metabolism and in the emergence of bacterial persisters.</p>}}, author = {{Hauryliuk, Vasili and Atkinson, Gemma C. and Murakami, Katsuhiko S. and Tenson, Tanel and Gerdes, Kenn}}, issn = {{1740-1526}}, language = {{eng}}, month = {{05}}, number = {{5}}, pages = {{298--309}}, publisher = {{Nature Publishing Group}}, series = {{Nature Reviews Microbiology}}, title = {{Recent functional insights into the role of (p)ppGpp in bacterial physiology}}, url = {{http://dx.doi.org/10.1038/nrmicro3448}}, doi = {{10.1038/nrmicro3448}}, volume = {{13}}, year = {{2015}}, }