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Fracture Risk Assessment in Older Adults Using a Combination of Selected Quantitative Computed Tomography Bone Measures: A Subanalysis of the Age, Gene/Environment Susceptibility-Reykjavik Study

Rianon, Nahid J.; Lang, Thomas F.; Siggeirsdottir, Kristin; Sigurdsson, Gunnar; Eiriksdottir, Gudny; Sigurdsson, Sigurdur; Jonsson, Brynjolfur LU ; Garcia, Melissa; Yu, Binbing and Kapadia, Asha S., et al. (2014) In Journal of Clinical Densitometry 17(1). p.25-31
Abstract
Bone mineral density (BMD) and geometric bone measures are individually associated with prevalent osteoporotic fractures. Whether an aggregate of these measures would better associate with fractures has not been examined. We examined relationships between self-reported fractures and selected bone measures acquired by quantitative computerized tomography (QCT), a composite bone score, and QCT-acquired dual-energy X-ray absorptiometry-like total femur BMD in 2110 men and 2682 women in the Age, Gene/Environment Susceptibility-Reykjavik Study. The combined bone score was generated by summing gender-specific Z-scores for 4 QCT measures: vertebral trabecular BMD, femur neck cortical thickness, femur neck trabecular BMD, and femur neck minimal... (More)
Bone mineral density (BMD) and geometric bone measures are individually associated with prevalent osteoporotic fractures. Whether an aggregate of these measures would better associate with fractures has not been examined. We examined relationships between self-reported fractures and selected bone measures acquired by quantitative computerized tomography (QCT), a composite bone score, and QCT-acquired dual-energy X-ray absorptiometry-like total femur BMD in 2110 men and 2682 women in the Age, Gene/Environment Susceptibility-Reykjavik Study. The combined bone score was generated by summing gender-specific Z-scores for 4 QCT measures: vertebral trabecular BMD, femur neck cortical thickness, femur neck trabecular BMD, and femur neck minimal cross-sectional area. Except for the latter measure, lower scores for QCT measures, singly and combined, showed positive (p < 0.05) associations with fractures. Results remained the same in stratified models for participants not taking bone-promoting medication. In women on bone-promoting medication, greater femur neck cortical thickness and trabecular BMD were significantly associated with fracture status. However, the association between fracture and combined bone score was not stronger than the associations between fracture and individual measures or total femur BMD. Thus, the selected measures did not all similarly associate with fracture status and did not appear to have an additive effect on fracture status. (Less)
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keywords
Bone mineral density, bone strength, elderly, fracture, quantitative, computerized tomography
in
Journal of Clinical Densitometry
volume
17
issue
1
pages
25 - 31
publisher
Elsevier
external identifiers
  • wos:000331598300006
  • scopus:84894979942
ISSN
1094-6950
DOI
10.1016/j.jocd.2013.03.005
language
English
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yes
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80c6cd1f-726e-4b77-8c3e-2a6ba93ebc1a (old id 4367199)
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2014-04-07 09:20:22
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2017-09-24 03:21:09
@article{80c6cd1f-726e-4b77-8c3e-2a6ba93ebc1a,
  abstract     = {Bone mineral density (BMD) and geometric bone measures are individually associated with prevalent osteoporotic fractures. Whether an aggregate of these measures would better associate with fractures has not been examined. We examined relationships between self-reported fractures and selected bone measures acquired by quantitative computerized tomography (QCT), a composite bone score, and QCT-acquired dual-energy X-ray absorptiometry-like total femur BMD in 2110 men and 2682 women in the Age, Gene/Environment Susceptibility-Reykjavik Study. The combined bone score was generated by summing gender-specific Z-scores for 4 QCT measures: vertebral trabecular BMD, femur neck cortical thickness, femur neck trabecular BMD, and femur neck minimal cross-sectional area. Except for the latter measure, lower scores for QCT measures, singly and combined, showed positive (p &lt; 0.05) associations with fractures. Results remained the same in stratified models for participants not taking bone-promoting medication. In women on bone-promoting medication, greater femur neck cortical thickness and trabecular BMD were significantly associated with fracture status. However, the association between fracture and combined bone score was not stronger than the associations between fracture and individual measures or total femur BMD. Thus, the selected measures did not all similarly associate with fracture status and did not appear to have an additive effect on fracture status.},
  author       = {Rianon, Nahid J. and Lang, Thomas F. and Siggeirsdottir, Kristin and Sigurdsson, Gunnar and Eiriksdottir, Gudny and Sigurdsson, Sigurdur and Jonsson, Brynjolfur and Garcia, Melissa and Yu, Binbing and Kapadia, Asha S. and Taylor, Wendell C. and Selwyn, Beatrice J. and Gudnason, Vilmundur and Launer, Lenore J. and Harris, Tamara B.},
  issn         = {1094-6950},
  keyword      = {Bone mineral density,bone strength,elderly,fracture,quantitative,computerized tomography},
  language     = {eng},
  number       = {1},
  pages        = {25--31},
  publisher    = {Elsevier},
  series       = {Journal of Clinical Densitometry},
  title        = {Fracture Risk Assessment in Older Adults Using a Combination of Selected Quantitative Computed Tomography Bone Measures: A Subanalysis of the Age, Gene/Environment Susceptibility-Reykjavik Study},
  url          = {http://dx.doi.org/10.1016/j.jocd.2013.03.005},
  volume       = {17},
  year         = {2014},
}