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J-curve association between alcohol intake and varicose veins in Japan : The Shimane CoHRE Study

Kohno, Kunie ; Niihara, Hiroyuki ; Hamano, Tsuyoshi ; Takeda, Miwako ; Nakagawa, Yusei ; Shiwaku, Kuninori ; Nabika, Toru ; Zöller, Bengt LU ; Li, Xinjun LU and Sundquist, Kristina LU , et al. (2019) In Journal of Dermatology 46(10). p.902-906
Abstract

The effect of alcohol intake on varicose veins (VV) has not been determined by its consumption level. The aim of this study was to investigate the association between alcohol intake and VV in an elderly general population. Using a cross-sectional approach, the Shimane CoHRE Study data, comprising a total of 1060 participants, were analyzed. By multivariate regression analysis adjusted with basic characteristics, past work history, lifestyle-related factors and medical history, compared with non-drinkers, mild drinkers (<20.0 g/day) showed a significantly lower adjusted odds ratio (aOR) of VV (aOR = 0.64, P = 0.036). In a similar way, regular drinkers (1-5 days/week) showed a significantly lower aOR of VV when compared with occasional... (More)

The effect of alcohol intake on varicose veins (VV) has not been determined by its consumption level. The aim of this study was to investigate the association between alcohol intake and VV in an elderly general population. Using a cross-sectional approach, the Shimane CoHRE Study data, comprising a total of 1060 participants, were analyzed. By multivariate regression analysis adjusted with basic characteristics, past work history, lifestyle-related factors and medical history, compared with non-drinkers, mild drinkers (<20.0 g/day) showed a significantly lower adjusted odds ratio (aOR) of VV (aOR = 0.64, P = 0.036). In a similar way, regular drinkers (1-5 days/week) showed a significantly lower aOR of VV when compared with occasional drinkers (aOR = 0.57, P = 0.032). VV and alcohol intake showed J-curve relationships. In a stratified analysis by alcohol consumption levels, the association of smoking and VV were also observed in moderate to heavy drinkers and habitual drinkers. These findings can provide better understanding of pathophysiological mechanism and be used for evidence-based patient education.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Dermatology
volume
46
issue
10
pages
902 - 906
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • scopus:85070475442
  • pmid:31353631
ISSN
1346-8138
DOI
10.1111/1346-8138.15022
language
English
LU publication?
yes
additional info
© 2019 Japanese Dermatological Association.
id
436ffc2b-ca40-40e6-b848-b07d1bcbec8d
date added to LUP
2019-08-01 13:53:31
date last changed
2020-10-20 03:12:06
@article{436ffc2b-ca40-40e6-b848-b07d1bcbec8d,
  abstract     = {<p>The effect of alcohol intake on varicose veins (VV) has not been determined by its consumption level. The aim of this study was to investigate the association between alcohol intake and VV in an elderly general population. Using a cross-sectional approach, the Shimane CoHRE Study data, comprising a total of 1060 participants, were analyzed. By multivariate regression analysis adjusted with basic characteristics, past work history, lifestyle-related factors and medical history, compared with non-drinkers, mild drinkers (&lt;20.0 g/day) showed a significantly lower adjusted odds ratio (aOR) of VV (aOR = 0.64, P = 0.036). In a similar way, regular drinkers (1-5 days/week) showed a significantly lower aOR of VV when compared with occasional drinkers (aOR = 0.57, P = 0.032). VV and alcohol intake showed J-curve relationships. In a stratified analysis by alcohol consumption levels, the association of smoking and VV were also observed in moderate to heavy drinkers and habitual drinkers. These findings can provide better understanding of pathophysiological mechanism and be used for evidence-based patient education.</p>},
  author       = {Kohno, Kunie and Niihara, Hiroyuki and Hamano, Tsuyoshi and Takeda, Miwako and Nakagawa, Yusei and Shiwaku, Kuninori and Nabika, Toru and Zöller, Bengt and Li, Xinjun and Sundquist, Kristina and Sundquist, Jan and Morita, Eishin},
  issn         = {1346-8138},
  language     = {eng},
  month        = {07},
  number       = {10},
  pages        = {902--906},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Journal of Dermatology},
  title        = {J-curve association between alcohol intake and varicose veins in Japan : The Shimane CoHRE Study},
  url          = {http://dx.doi.org/10.1111/1346-8138.15022},
  doi          = {10.1111/1346-8138.15022},
  volume       = {46},
  year         = {2019},
}