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Distinct inflammatory mediator patterns characterize infectious and sterile systemic inflammation in febrile neutropenic hematology patients.

Wennerås, Christine; Hagberg, Lars; Andersson, Rune; Hynsjö, Lars; Lindahl, Anders; Okroj, Marcin LU ; Blom, Anna LU ; Johansson, Peter; Andreasson, Björn and Gottfries, Johan, et al. (2014) In PLoS ONE 9(3).
Abstract
Invasive infections and sterile tissue damage can both give rise to systemic inflammation with fever and production of inflammatory mediators. This makes it difficult to diagnose infections in patients who are already inflamed, e.g. due to cell and tissue damage. For example, fever in patients with hematological malignancies may depend on infection, lysis of malignant cells, and/or chemotherapy-induced mucosal damage. We hypothesized that it would be possible to distinguish patterns of inflammatory mediators characterizing infectious and non-infectious causes of inflammation, respectively. Analysis of a broad range of parameters using a multivariate method of pattern recognition was done for this purpose.
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publication status
published
subject
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PLoS ONE
volume
9
issue
3
publisher
Public Library of Science
external identifiers
  • pmid:24642872
  • wos:000333259900120
  • scopus:84898913716
ISSN
1932-6203
DOI
10.1371/journal.pone.0092319
language
English
LU publication?
yes
id
6b7f547f-c6f6-447b-bf13-c7ac2ebc541e (old id 4382981)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24642872?dopt=Abstract
date added to LUP
2014-04-03 20:24:33
date last changed
2017-08-13 04:02:42
@article{6b7f547f-c6f6-447b-bf13-c7ac2ebc541e,
  abstract     = {Invasive infections and sterile tissue damage can both give rise to systemic inflammation with fever and production of inflammatory mediators. This makes it difficult to diagnose infections in patients who are already inflamed, e.g. due to cell and tissue damage. For example, fever in patients with hematological malignancies may depend on infection, lysis of malignant cells, and/or chemotherapy-induced mucosal damage. We hypothesized that it would be possible to distinguish patterns of inflammatory mediators characterizing infectious and non-infectious causes of inflammation, respectively. Analysis of a broad range of parameters using a multivariate method of pattern recognition was done for this purpose.},
  articleno    = {e92319},
  author       = {Wennerås, Christine and Hagberg, Lars and Andersson, Rune and Hynsjö, Lars and Lindahl, Anders and Okroj, Marcin and Blom, Anna and Johansson, Peter and Andreasson, Björn and Gottfries, Johan and Wold, Agnes E},
  issn         = {1932-6203},
  language     = {eng},
  number       = {3},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Distinct inflammatory mediator patterns characterize infectious and sterile systemic inflammation in febrile neutropenic hematology patients.},
  url          = {http://dx.doi.org/10.1371/journal.pone.0092319},
  volume       = {9},
  year         = {2014},
}