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Impact of colostrum and plasma immunoglobulin intake on hippocampus structure during early postnatal development in pigs.

Pierzynowski, Stefan LU ; Ushakova, Galyna; Kovalenko, Tatiana; Osadchenko, Iryna; Goncharova, Kateryna; Gustavsson, Per LU ; Prykhodko, Olena LU ; Wolinski, Jarek; Slupecka, Monika and Ochniewicz, Piotr, et al. (2014) In International Journal of Developmental Neuroscience 35. p.64-71
Abstract
The first milk, colostrum, is an important source of nutrients and an exclusive source of immunoglobulins (Ig), essential for the growth and protection from infection of newborn pigs. Colostrum intake has also been shown to affect the vitality and behaviour of neonatal pigs. The objective of this study was to evaluate the effects of feeding colostrum and plasma immunoglobulin on brain development in neonatal pigs. Positive correlations were found between growth, levels of total protein and IgG in blood plasma and hippocampus development in sow-reared piglets during the first 3 postnatal days. In piglets fed an elemental diet (ED) for 24h, a reduced body weight, a lower plasma protein level and a decreased level of astrocyte specific... (More)
The first milk, colostrum, is an important source of nutrients and an exclusive source of immunoglobulins (Ig), essential for the growth and protection from infection of newborn pigs. Colostrum intake has also been shown to affect the vitality and behaviour of neonatal pigs. The objective of this study was to evaluate the effects of feeding colostrum and plasma immunoglobulin on brain development in neonatal pigs. Positive correlations were found between growth, levels of total protein and IgG in blood plasma and hippocampus development in sow-reared piglets during the first 3 postnatal days. In piglets fed an elemental diet (ED) for 24h, a reduced body weight, a lower plasma protein level and a decreased level of astrocyte specific protein in the hippocampus was observed, as compared to those that were sow-reared. The latter was coincident with a reduced microgliogenesis and an essentially diminished number of neurons in the CA1 area of the hippocampus after 72h. Supplementation of the ED with purified plasma Ig, improved the gliogenesis and supported the trophic and immune status of the hippocampus. The data obtained indicate that the development of the hippocampus structure is improved by colostrum or an Ig-supplemented elemental diet in order to stimulate brain protein synthesis and its development during the early postnatal period. (Less)
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International Journal of Developmental Neuroscience
volume
35
pages
64 - 71
publisher
Elsevier
external identifiers
  • pmid:24642047
  • wos:000336474500009
  • scopus:84897987749
ISSN
1873-474X
DOI
10.1016/j.ijdevneu.2014.03.003
language
English
LU publication?
yes
id
0a483126-6d10-4f52-83a9-ce07f76019ad (old id 4383009)
date added to LUP
2014-04-25 10:13:39
date last changed
2017-07-23 03:01:59
@article{0a483126-6d10-4f52-83a9-ce07f76019ad,
  abstract     = {The first milk, colostrum, is an important source of nutrients and an exclusive source of immunoglobulins (Ig), essential for the growth and protection from infection of newborn pigs. Colostrum intake has also been shown to affect the vitality and behaviour of neonatal pigs. The objective of this study was to evaluate the effects of feeding colostrum and plasma immunoglobulin on brain development in neonatal pigs. Positive correlations were found between growth, levels of total protein and IgG in blood plasma and hippocampus development in sow-reared piglets during the first 3 postnatal days. In piglets fed an elemental diet (ED) for 24h, a reduced body weight, a lower plasma protein level and a decreased level of astrocyte specific protein in the hippocampus was observed, as compared to those that were sow-reared. The latter was coincident with a reduced microgliogenesis and an essentially diminished number of neurons in the CA1 area of the hippocampus after 72h. Supplementation of the ED with purified plasma Ig, improved the gliogenesis and supported the trophic and immune status of the hippocampus. The data obtained indicate that the development of the hippocampus structure is improved by colostrum or an Ig-supplemented elemental diet in order to stimulate brain protein synthesis and its development during the early postnatal period.},
  author       = {Pierzynowski, Stefan and Ushakova, Galyna and Kovalenko, Tatiana and Osadchenko, Iryna and Goncharova, Kateryna and Gustavsson, Per and Prykhodko, Olena and Wolinski, Jarek and Slupecka, Monika and Ochniewicz, Piotr and Weström, Björn and Skibo, Galina},
  issn         = {1873-474X},
  language     = {eng},
  pages        = {64--71},
  publisher    = {Elsevier},
  series       = {International Journal of Developmental Neuroscience},
  title        = {Impact of colostrum and plasma immunoglobulin intake on hippocampus structure during early postnatal development in pigs.},
  url          = {http://dx.doi.org/10.1016/j.ijdevneu.2014.03.003},
  volume       = {35},
  year         = {2014},
}