Epigenetic adaptation to regular exercise in humans.
Ling, Charlotte LU
and Rönn, Tina
LU
(2014)
In Drug Discovery Today
19(7).
p.1015-1018
- Abstract
- Regular exercise has numerous health benefits, for example, it reduces the risk of cardiovascular disease and cancer. It has also been shown that the risk of type 2 diabetes can be halved in high-risk groups through nonpharmacological lifestyle interventions involving exercise and diet. Nevertheless, the number of people living a sedentary life is dramatically increasing worldwide. Researchers have searched for molecular mechanisms explaining the health benefits of regular exercise for decades and it is well established that exercise alters the gene expression pattern in multiple tissues. However, until recently it was unknown that regular exercise can modify the genome-wide DNA methylation pattern in humans. This review will focus on... (More)
- Regular exercise has numerous health benefits, for example, it reduces the risk of cardiovascular disease and cancer. It has also been shown that the risk of type 2 diabetes can be halved in high-risk groups through nonpharmacological lifestyle interventions involving exercise and diet. Nevertheless, the number of people living a sedentary life is dramatically increasing worldwide. Researchers have searched for molecular mechanisms explaining the health benefits of regular exercise for decades and it is well established that exercise alters the gene expression pattern in multiple tissues. However, until recently it was unknown that regular exercise can modify the genome-wide DNA methylation pattern in humans. This review will focus on recent progress in the field of regular exercise and epigenetics. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4383177
- author
- Ling, Charlotte
LU
and Rönn, Tina
LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Drug Discovery Today
- volume
- 19
- issue
- 7
- pages
- 1015 - 1018
- publisher
- Elsevier
- external identifiers
-
- pmid:24632002
- wos:000339148700030
- scopus:84903786303
- pmid:24632002
- ISSN
- 1878-5832
- DOI
- 10.1016/j.drudis.2014.03.006
- language
- English
- LU publication?
- yes
- id
- daad7be1-c053-4688-bd92-dfbf534aab34 (old id 4383177)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24632002?dopt=Abstract
- date added to LUP
- 2016-04-01 11:05:52
- date last changed
- 2022-09-18 20:55:18
@article{daad7be1-c053-4688-bd92-dfbf534aab34,
abstract = {{Regular exercise has numerous health benefits, for example, it reduces the risk of cardiovascular disease and cancer. It has also been shown that the risk of type 2 diabetes can be halved in high-risk groups through nonpharmacological lifestyle interventions involving exercise and diet. Nevertheless, the number of people living a sedentary life is dramatically increasing worldwide. Researchers have searched for molecular mechanisms explaining the health benefits of regular exercise for decades and it is well established that exercise alters the gene expression pattern in multiple tissues. However, until recently it was unknown that regular exercise can modify the genome-wide DNA methylation pattern in humans. This review will focus on recent progress in the field of regular exercise and epigenetics.}},
author = {{Ling, Charlotte and Rönn, Tina}},
issn = {{1878-5832}},
language = {{eng}},
number = {{7}},
pages = {{1015--1018}},
publisher = {{Elsevier}},
series = {{Drug Discovery Today}},
title = {{Epigenetic adaptation to regular exercise in humans.}},
url = {{http://dx.doi.org/10.1016/j.drudis.2014.03.006}},
doi = {{10.1016/j.drudis.2014.03.006}},
volume = {{19}},
year = {{2014}},
}