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Epigenetic adaptation to regular exercise in humans.

Ling, Charlotte LU and Rönn, Tina LU (2014) In Drug Discovery Today 19(7). p.1015-1018
Abstract
Regular exercise has numerous health benefits, for example, it reduces the risk of cardiovascular disease and cancer. It has also been shown that the risk of type 2 diabetes can be halved in high-risk groups through nonpharmacological lifestyle interventions involving exercise and diet. Nevertheless, the number of people living a sedentary life is dramatically increasing worldwide. Researchers have searched for molecular mechanisms explaining the health benefits of regular exercise for decades and it is well established that exercise alters the gene expression pattern in multiple tissues. However, until recently it was unknown that regular exercise can modify the genome-wide DNA methylation pattern in humans. This review will focus on... (More)
Regular exercise has numerous health benefits, for example, it reduces the risk of cardiovascular disease and cancer. It has also been shown that the risk of type 2 diabetes can be halved in high-risk groups through nonpharmacological lifestyle interventions involving exercise and diet. Nevertheless, the number of people living a sedentary life is dramatically increasing worldwide. Researchers have searched for molecular mechanisms explaining the health benefits of regular exercise for decades and it is well established that exercise alters the gene expression pattern in multiple tissues. However, until recently it was unknown that regular exercise can modify the genome-wide DNA methylation pattern in humans. This review will focus on recent progress in the field of regular exercise and epigenetics. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Drug Discovery Today
volume
19
issue
7
pages
1015 - 1018
publisher
Elsevier
external identifiers
  • pmid:24632002
  • wos:000339148700030
  • scopus:84903786303
ISSN
1878-5832
DOI
10.1016/j.drudis.2014.03.006
language
English
LU publication?
yes
id
daad7be1-c053-4688-bd92-dfbf534aab34 (old id 4383177)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24632002?dopt=Abstract
date added to LUP
2014-04-03 16:45:39
date last changed
2017-10-08 03:21:25
@article{daad7be1-c053-4688-bd92-dfbf534aab34,
  abstract     = {Regular exercise has numerous health benefits, for example, it reduces the risk of cardiovascular disease and cancer. It has also been shown that the risk of type 2 diabetes can be halved in high-risk groups through nonpharmacological lifestyle interventions involving exercise and diet. Nevertheless, the number of people living a sedentary life is dramatically increasing worldwide. Researchers have searched for molecular mechanisms explaining the health benefits of regular exercise for decades and it is well established that exercise alters the gene expression pattern in multiple tissues. However, until recently it was unknown that regular exercise can modify the genome-wide DNA methylation pattern in humans. This review will focus on recent progress in the field of regular exercise and epigenetics.},
  author       = {Ling, Charlotte and Rönn, Tina},
  issn         = {1878-5832},
  language     = {eng},
  number       = {7},
  pages        = {1015--1018},
  publisher    = {Elsevier},
  series       = {Drug Discovery Today},
  title        = {Epigenetic adaptation to regular exercise in humans.},
  url          = {http://dx.doi.org/10.1016/j.drudis.2014.03.006},
  volume       = {19},
  year         = {2014},
}