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Low myelinated nerve-fibre density may lead to symptoms associated with nerve entrapment in vibration-induced neuropathy.

Dahlin, Lars LU ; Sandén, Helena; Dahlin, Erik; Zimmerman, Malin LU ; Thomsen, Niels LU and Björkman, Anders LU (2014) In Journal of Occupational Medicine and Toxicology 9(1).
Abstract
Prolonged exposure to hand-held vibrating tools may cause a hand-arm vibration syndrome (HAVS), sometimes with individual susceptibility. The neurological symptoms seen in HAVS are similar to symptoms seen in patients with carpal tunnel syndrome (CTS) and there is a strong relationship between CTS and the use of vibrating tools. Vibration exposure to the hand is known to induce demyelination of nerve fibres and to reduce the density of myelinated nerve fibres in the nerve trunks. In view of current knowledge regarding the clinical effects of low nerve-fibre density in patients with neuropathies of varying aetiologies, such as diabetes, and that such a low density may lead to nerve entrapment symptoms, a reduction in myelinated nerve fibres... (More)
Prolonged exposure to hand-held vibrating tools may cause a hand-arm vibration syndrome (HAVS), sometimes with individual susceptibility. The neurological symptoms seen in HAVS are similar to symptoms seen in patients with carpal tunnel syndrome (CTS) and there is a strong relationship between CTS and the use of vibrating tools. Vibration exposure to the hand is known to induce demyelination of nerve fibres and to reduce the density of myelinated nerve fibres in the nerve trunks. In view of current knowledge regarding the clinical effects of low nerve-fibre density in patients with neuropathies of varying aetiologies, such as diabetes, and that such a low density may lead to nerve entrapment symptoms, a reduction in myelinated nerve fibres may be a key factor behind the symptoms also seen in patients with HAVS and CTS. Furthermore, a reduced nerve-fibre density may result in a changed afferent signal pattern, resulting in turn in alterations in the brain, further prompting the symptoms seen in patients with HAVS and CTS. We conclude that a low nerve-fibre density lead to symptoms associated with nerve entrapment, such as CTS, in some patients with HAVS. (Less)
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organization
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type
Contribution to journal
publication status
published
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in
Journal of Occupational Medicine and Toxicology
volume
9
issue
1
publisher
BioMed Central
external identifiers
  • pmid:24606755
  • wos:000333364700001
  • scopus:84898004046
ISSN
1745-6673
DOI
10.1186/1745-6673-9-7
language
English
LU publication?
yes
id
a2eb5110-e488-4668-a51a-e5de82ad55dd (old id 4383712)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24606755?dopt=Abstract
date added to LUP
2014-04-02 20:01:15
date last changed
2017-03-29 11:25:53
@article{a2eb5110-e488-4668-a51a-e5de82ad55dd,
  abstract     = {Prolonged exposure to hand-held vibrating tools may cause a hand-arm vibration syndrome (HAVS), sometimes with individual susceptibility. The neurological symptoms seen in HAVS are similar to symptoms seen in patients with carpal tunnel syndrome (CTS) and there is a strong relationship between CTS and the use of vibrating tools. Vibration exposure to the hand is known to induce demyelination of nerve fibres and to reduce the density of myelinated nerve fibres in the nerve trunks. In view of current knowledge regarding the clinical effects of low nerve-fibre density in patients with neuropathies of varying aetiologies, such as diabetes, and that such a low density may lead to nerve entrapment symptoms, a reduction in myelinated nerve fibres may be a key factor behind the symptoms also seen in patients with HAVS and CTS. Furthermore, a reduced nerve-fibre density may result in a changed afferent signal pattern, resulting in turn in alterations in the brain, further prompting the symptoms seen in patients with HAVS and CTS. We conclude that a low nerve-fibre density lead to symptoms associated with nerve entrapment, such as CTS, in some patients with HAVS.},
  articleno    = {7},
  author       = {Dahlin, Lars and Sandén, Helena and Dahlin, Erik and Zimmerman, Malin and Thomsen, Niels and Björkman, Anders},
  issn         = {1745-6673},
  language     = {eng},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {Journal of Occupational Medicine and Toxicology},
  title        = {Low myelinated nerve-fibre density may lead to symptoms associated with nerve entrapment in vibration-induced neuropathy.},
  url          = {http://dx.doi.org/10.1186/1745-6673-9-7},
  volume       = {9},
  year         = {2014},
}