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Prevalence of thyroid autoimmunity in children with celiac disease compared to healthy 12-year olds.

vanderPals, Maria LU ; Ivarsson, Anneli; Norström, Fredrik; Högberg, Lotta; Svensson, Johan LU and Carlsson, Annelie LU (2014) In Autoimmune Diseases 2014(Jan 27).
Abstract
Objectives. Studies have suggested a correlation between untreated celiac disease and risk for other autoimmune diseases. We investigated the prevalence of thyroid autoimmunity in 12-year-old children (i) with symptomatic celiac disease diagnosed and treated with a gluten-free diet, (ii) with screening-detected untreated celiac disease, and (iii) without celiac disease. Methods. Blood samples from 12632 children were collected. All celiac disease cases, previously diagnosed and newly screening-detected, were identified. Per case, 4 referents were matched. Blood samples were analyzed for autoantibodies against thyroid peroxidase (TPOAb). The cut-off value for TPO positivity was set to 100 U/mL. Results. Altogether, 335 celiac disease cases... (More)
Objectives. Studies have suggested a correlation between untreated celiac disease and risk for other autoimmune diseases. We investigated the prevalence of thyroid autoimmunity in 12-year-old children (i) with symptomatic celiac disease diagnosed and treated with a gluten-free diet, (ii) with screening-detected untreated celiac disease, and (iii) without celiac disease. Methods. Blood samples from 12632 children were collected. All celiac disease cases, previously diagnosed and newly screening-detected, were identified. Per case, 4 referents were matched. Blood samples were analyzed for autoantibodies against thyroid peroxidase (TPOAb). The cut-off value for TPO positivity was set to 100 U/mL. Results. Altogether, 335 celiac disease cases were found. In the entire celiac disease group, 7.2% (24/335) had elevated titers of TPOAb compared to 2.8% (48/1695) of the referents. Among the previously diagnosed celiac disease cases, 7.5% (7/93, OR 2.8, 95% CI 1.2-6.4) was TPOAb positive and among screening-detected cases, 7.0% (17/242, OR 2.6, 95% CI 1.5-4.6) was TPOAb positive. Conclusion. Children with celiac disease showed a higher prevalence of thyroid autoimmunity. We could not confirm the hypothesis that untreated celiac disease is associated with increased risk of developing thyroid autoimmunity. Early initiation of celiac disease treatment might not lower the risk for other autoimmune diseases. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Autoimmune Diseases
volume
2014
issue
Jan 27
publisher
Hindawi Publishing Corporation
external identifiers
  • pmid:24592326
  • scopus:84896900049
ISSN
2090-0422
DOI
10.1155/2014/417356
language
English
LU publication?
yes
id
3a042668-d2c6-4d22-98a6-322033b1b36b (old id 4383956)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24592326?dopt=Abstract
date added to LUP
2014-04-01 23:23:30
date last changed
2017-10-22 04:05:56
@article{3a042668-d2c6-4d22-98a6-322033b1b36b,
  abstract     = {Objectives. Studies have suggested a correlation between untreated celiac disease and risk for other autoimmune diseases. We investigated the prevalence of thyroid autoimmunity in 12-year-old children (i) with symptomatic celiac disease diagnosed and treated with a gluten-free diet, (ii) with screening-detected untreated celiac disease, and (iii) without celiac disease. Methods. Blood samples from 12632 children were collected. All celiac disease cases, previously diagnosed and newly screening-detected, were identified. Per case, 4 referents were matched. Blood samples were analyzed for autoantibodies against thyroid peroxidase (TPOAb). The cut-off value for TPO positivity was set to 100 U/mL. Results. Altogether, 335 celiac disease cases were found. In the entire celiac disease group, 7.2% (24/335) had elevated titers of TPOAb compared to 2.8% (48/1695) of the referents. Among the previously diagnosed celiac disease cases, 7.5% (7/93, OR 2.8, 95% CI 1.2-6.4) was TPOAb positive and among screening-detected cases, 7.0% (17/242, OR 2.6, 95% CI 1.5-4.6) was TPOAb positive. Conclusion. Children with celiac disease showed a higher prevalence of thyroid autoimmunity. We could not confirm the hypothesis that untreated celiac disease is associated with increased risk of developing thyroid autoimmunity. Early initiation of celiac disease treatment might not lower the risk for other autoimmune diseases.},
  articleno    = {417356},
  author       = {vanderPals, Maria and Ivarsson, Anneli and Norström, Fredrik and Högberg, Lotta and Svensson, Johan and Carlsson, Annelie},
  issn         = {2090-0422},
  language     = {eng},
  number       = {Jan 27},
  publisher    = {Hindawi Publishing Corporation},
  series       = {Autoimmune Diseases},
  title        = {Prevalence of thyroid autoimmunity in children with celiac disease compared to healthy 12-year olds.},
  url          = {http://dx.doi.org/10.1155/2014/417356},
  volume       = {2014},
  year         = {2014},
}