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Incidence and prognostic significance of karyotypic subgroups in older patients with acute myeloid leukemia: the Swedish population-based experience.

Lazarevic, Vladimir LU ; Hörstedt, Ann-sofi LU ; Johansson, Erik LU ; Antunovic, P; Billström, R; Derolf, A; Hulegårdh, E; Lehmann, S; Möllgård, L and Nilsson, C, et al. (2014) In Blood Cancer Journal 4(Feb 28). p.188-188
Abstract
The Swedish population-based acute myeloid leukemia registry contains data from 3251 patients (excluding acute promyelocytic leukemia) diagnosed between 1997 and 2006. Informative cytogenetic data from 1893 patients were retrospectively added, including 1054 patients aged between 60 and 79 years. Clonal abnormalities were found in 57% of the informative karyotypes. Karyotypic patterns differed by age: t(8;21), inv(16) and t(11q23) were more common in younger patients, whereas loss of 5q, 7q and 17p, monosomal karyotype (MK) and complex karyotypes were more common in older patients. Loss of 5q, 7q and 17p often occurred together within MK. Patients with 5 chromosome abnormalities had worse overall survival than those with fewer... (More)
The Swedish population-based acute myeloid leukemia registry contains data from 3251 patients (excluding acute promyelocytic leukemia) diagnosed between 1997 and 2006. Informative cytogenetic data from 1893 patients were retrospectively added, including 1054 patients aged between 60 and 79 years. Clonal abnormalities were found in 57% of the informative karyotypes. Karyotypic patterns differed by age: t(8;21), inv(16) and t(11q23) were more common in younger patients, whereas loss of 5q, 7q and 17p, monosomal karyotype (MK) and complex karyotypes were more common in older patients. Loss of 5q, 7q and 17p often occurred together within MK. Patients with 5 chromosome abnormalities had worse overall survival than those with fewer abnormalities or normal karyotype in all age groups. Loss of 5q, 7q and/or 17p had, in contrast to MK, a further negative impact on survival. Multivariable Cox regression analyses on risk factors in patients <80 years with cytogenetic abnormalities and intensive treatment revealed that age and performance status had the most significant impact on survival (both P<0.001), followed by sex (P=0.0135) and a karyotype including -7/del(7q) (P=0.048). (Less)
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Blood Cancer Journal
volume
4
issue
Feb 28
pages
188 - 188
publisher
Nature Publishing Group
external identifiers
  • pmid:24583534
  • wos:000332631700008
  • scopus:84895439646
ISSN
2044-5385
DOI
10.1038/bcj.2014.10
language
English
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yes
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a3101c31-3347-41d1-9776-2ca57c3d48b4 (old id 4384309)
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http://www.ncbi.nlm.nih.gov/pubmed/24583534?dopt=Abstract
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2014-04-01 18:40:19
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@article{a3101c31-3347-41d1-9776-2ca57c3d48b4,
  abstract     = {The Swedish population-based acute myeloid leukemia registry contains data from 3251 patients (excluding acute promyelocytic leukemia) diagnosed between 1997 and 2006. Informative cytogenetic data from 1893 patients were retrospectively added, including 1054 patients aged between 60 and 79 years. Clonal abnormalities were found in 57% of the informative karyotypes. Karyotypic patterns differed by age: t(8;21), inv(16) and t(11q23) were more common in younger patients, whereas loss of 5q, 7q and 17p, monosomal karyotype (MK) and complex karyotypes were more common in older patients. Loss of 5q, 7q and 17p often occurred together within MK. Patients with 5 chromosome abnormalities had worse overall survival than those with fewer abnormalities or normal karyotype in all age groups. Loss of 5q, 7q and/or 17p had, in contrast to MK, a further negative impact on survival. Multivariable Cox regression analyses on risk factors in patients &lt;80 years with cytogenetic abnormalities and intensive treatment revealed that age and performance status had the most significant impact on survival (both P&lt;0.001), followed by sex (P=0.0135) and a karyotype including -7/del(7q) (P=0.048).},
  author       = {Lazarevic, Vladimir and Hörstedt, Ann-sofi and Johansson, Erik and Antunovic, P and Billström, R and Derolf, A and Hulegårdh, E and Lehmann, S and Möllgård, L and Nilsson, C and Peterson, Stefan and Stockelberg, D and Uggla, B and Wennström, L and Wahlin, A and Höglund, M and Juliusson, Gunnar},
  issn         = {2044-5385},
  language     = {eng},
  number       = {Feb 28},
  pages        = {188--188},
  publisher    = {Nature Publishing Group},
  series       = {Blood Cancer Journal},
  title        = {Incidence and prognostic significance of karyotypic subgroups in older patients with acute myeloid leukemia: the Swedish population-based experience.},
  url          = {http://dx.doi.org/10.1038/bcj.2014.10},
  volume       = {4},
  year         = {2014},
}