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Structure and Function of IGA

Bemark, Mats LU orcid and Spencer, Jo (2024) p.1-16
Abstract
In mammals, IgA is the antibody class that is produced in largest quantities. The main producers are plasma cells located in the lamina propria at mucosal surfaces that secrete it as dimers covalently linked to the J chain. Polymeric immunoglobulin receptors (pIgRs) expressed on epithelial cells bind to dimeric IgA molecules and mediate basolateral to apical transcytosis, before IgA is released into the lumen complexed to the secretory component (SC) of the pIgR. Significant amount of IgA is also produced by plasma cells in bone marrow and monomeric IgA antibodies are found in serum. In this chapter we review the structure of IgA molecules and the genes encoding it, as well as its induction, transport and functions.
Please use this url to cite or link to this publication:
author
and
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Reference Module in Life Sciences
pages
1 - 16
publisher
Elsevier
ISBN
9780128096338
DOI
10.1016/B978-0-128-24465-4.00094-6
language
English
LU publication?
no
id
43d83011-2f6c-4745-bdb5-9043a14acfa6
date added to LUP
2024-11-21 18:54:01
date last changed
2025-04-04 15:04:50
@inbook{43d83011-2f6c-4745-bdb5-9043a14acfa6,
  abstract     = {{In mammals, IgA is the antibody class that is produced in largest quantities. The main producers are plasma cells located in the lamina propria at mucosal surfaces that secrete it as dimers covalently linked to the J chain. Polymeric immunoglobulin receptors (pIgRs) expressed on epithelial cells bind to dimeric IgA molecules and mediate basolateral to apical transcytosis, before IgA is released into the lumen complexed to the secretory component (SC) of the pIgR. Significant amount of IgA is also produced by plasma cells in bone marrow and monomeric IgA antibodies are found in serum. In this chapter we review the structure of IgA molecules and the genes encoding it, as well as its induction, transport and functions.}},
  author       = {{Bemark, Mats and Spencer, Jo}},
  booktitle    = {{Reference Module in Life Sciences}},
  isbn         = {{9780128096338}},
  language     = {{eng}},
  pages        = {{1--16}},
  publisher    = {{Elsevier}},
  title        = {{Structure and Function of IGA}},
  url          = {{http://dx.doi.org/10.1016/B978-0-128-24465-4.00094-6}},
  doi          = {{10.1016/B978-0-128-24465-4.00094-6}},
  year         = {{2024}},
}