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Inherited genetic susceptibility to multiple myeloma

Morgan, G. J.; Johnson, D. C.; Weinhold, N.; Goldschmidt, H.; Landgren, O.; Lynch, H. T.; Hemminki, Kari LU and Houlston, R. S. (2014) In Leukemia 28(3). p.518-524
Abstract
Although the familial clustering of multiple myeloma (MM) supports the role of inherited susceptibility, only recently has direct evidence for genetic predisposition been demonstrated. A meta-analysis of two genome-wide association (GWA) studies has identified single-nucleotide polymorphisms (SNPs) localising to a number of genomic regions that are robustly associated with MM risk. In this review, we provide an overview of the evidence supporting a genetic contribution to the predisposition to MM and MGUS (monoclonal gammopathy of unknown significance), and the insight this gives into the biological basis of disease aetiology. We also highlight the promise of future approaches to identify further specific risk factors and their potential... (More)
Although the familial clustering of multiple myeloma (MM) supports the role of inherited susceptibility, only recently has direct evidence for genetic predisposition been demonstrated. A meta-analysis of two genome-wide association (GWA) studies has identified single-nucleotide polymorphisms (SNPs) localising to a number of genomic regions that are robustly associated with MM risk. In this review, we provide an overview of the evidence supporting a genetic contribution to the predisposition to MM and MGUS (monoclonal gammopathy of unknown significance), and the insight this gives into the biological basis of disease aetiology. We also highlight the promise of future approaches to identify further specific risk factors and their potential clinical utility. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
myeloma, SNP, MGUS
in
Leukemia
volume
28
issue
3
pages
518 - 524
publisher
Nature Publishing Group
external identifiers
  • wos:000332845700005
  • scopus:84895802141
ISSN
1476-5551
DOI
10.1038/leu.2013.344
language
English
LU publication?
yes
id
2ab5b02b-8b9f-47e2-b020-206b6ff17eec (old id 4410642)
date added to LUP
2014-05-05 07:19:20
date last changed
2017-08-13 04:09:10
@article{2ab5b02b-8b9f-47e2-b020-206b6ff17eec,
  abstract     = {Although the familial clustering of multiple myeloma (MM) supports the role of inherited susceptibility, only recently has direct evidence for genetic predisposition been demonstrated. A meta-analysis of two genome-wide association (GWA) studies has identified single-nucleotide polymorphisms (SNPs) localising to a number of genomic regions that are robustly associated with MM risk. In this review, we provide an overview of the evidence supporting a genetic contribution to the predisposition to MM and MGUS (monoclonal gammopathy of unknown significance), and the insight this gives into the biological basis of disease aetiology. We also highlight the promise of future approaches to identify further specific risk factors and their potential clinical utility.},
  author       = {Morgan, G. J. and Johnson, D. C. and Weinhold, N. and Goldschmidt, H. and Landgren, O. and Lynch, H. T. and Hemminki, Kari and Houlston, R. S.},
  issn         = {1476-5551},
  keyword      = {myeloma,SNP,MGUS},
  language     = {eng},
  number       = {3},
  pages        = {518--524},
  publisher    = {Nature Publishing Group},
  series       = {Leukemia},
  title        = {Inherited genetic susceptibility to multiple myeloma},
  url          = {http://dx.doi.org/10.1038/leu.2013.344},
  volume       = {28},
  year         = {2014},
}