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Synthesis of the Bioactive Benzochromenes Pulchrol and Pulchral, Metabolites of Bourreria pulchra

Killander, Dan LU and Sterner, Olov LU (2014) In European Journal of Organic Chemistry 2014(8). p.1594-1596
Abstract
The parasites Leshmania mexicana and Trypanosoma cruzi cause serious health problems, and few efficient treatments are available. Recently, the two benzochromenes pulchrol (1) and pulchral (2) were reported from the roots of Bourreria pulchra, and especially 1 but also 2 was found to be active towards the parasites. In this paper, we present a total synthesis of 1 and 2 to facilitate their biological evaluation. The synthesis is mild, short, and high yielding and suitable for a structure-activity relationship study.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Total synthesis, Natural products, Bioactive metabolites, Cross-coupling, Oxygen heterocycles
in
European Journal of Organic Chemistry
volume
2014
issue
8
pages
1594 - 1596
publisher
John Wiley & Sons
external identifiers
  • wos:000332161900003
  • scopus:84897588159
ISSN
1434-193X
DOI
10.1002/ejoc.201301792
language
English
LU publication?
yes
id
078cef0f-04b0-4be1-8091-52520f2ab1ee (old id 4414298)
date added to LUP
2014-04-30 08:00:23
date last changed
2017-10-22 03:16:54
@article{078cef0f-04b0-4be1-8091-52520f2ab1ee,
  abstract     = {The parasites Leshmania mexicana and Trypanosoma cruzi cause serious health problems, and few efficient treatments are available. Recently, the two benzochromenes pulchrol (1) and pulchral (2) were reported from the roots of Bourreria pulchra, and especially 1 but also 2 was found to be active towards the parasites. In this paper, we present a total synthesis of 1 and 2 to facilitate their biological evaluation. The synthesis is mild, short, and high yielding and suitable for a structure-activity relationship study.},
  author       = {Killander, Dan and Sterner, Olov},
  issn         = {1434-193X},
  keyword      = {Total synthesis,Natural products,Bioactive metabolites,Cross-coupling,Oxygen heterocycles},
  language     = {eng},
  number       = {8},
  pages        = {1594--1596},
  publisher    = {John Wiley & Sons},
  series       = {European Journal of Organic Chemistry},
  title        = {Synthesis of the Bioactive Benzochromenes Pulchrol and Pulchral, Metabolites of Bourreria pulchra},
  url          = {http://dx.doi.org/10.1002/ejoc.201301792},
  volume       = {2014},
  year         = {2014},
}