Synthesis of the Bioactive Benzochromenes Pulchrol and Pulchral, Metabolites of Bourreria pulchra
(2014) In European Journal of Organic Chemistry 2014(8). p.1594-1596- Abstract
- The parasites Leshmania mexicana and Trypanosoma cruzi cause serious health problems, and few efficient treatments are available. Recently, the two benzochromenes pulchrol (1) and pulchral (2) were reported from the roots of Bourreria pulchra, and especially 1 but also 2 was found to be active towards the parasites. In this paper, we present a total synthesis of 1 and 2 to facilitate their biological evaluation. The synthesis is mild, short, and high yielding and suitable for a structure-activity relationship study.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4414298
- author
- Killander, Dan LU and Sterner, Olov LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Total synthesis, Natural products, Bioactive metabolites, Cross-coupling, Oxygen heterocycles
- in
- European Journal of Organic Chemistry
- volume
- 2014
- issue
- 8
- pages
- 1594 - 1596
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000332161900003
- scopus:84897588159
- ISSN
- 1434-193X
- DOI
- 10.1002/ejoc.201301792
- language
- English
- LU publication?
- yes
- id
- 078cef0f-04b0-4be1-8091-52520f2ab1ee (old id 4414298)
- date added to LUP
- 2016-04-01 10:30:37
- date last changed
- 2022-03-27 17:00:34
@article{078cef0f-04b0-4be1-8091-52520f2ab1ee, abstract = {{The parasites Leshmania mexicana and Trypanosoma cruzi cause serious health problems, and few efficient treatments are available. Recently, the two benzochromenes pulchrol (1) and pulchral (2) were reported from the roots of Bourreria pulchra, and especially 1 but also 2 was found to be active towards the parasites. In this paper, we present a total synthesis of 1 and 2 to facilitate their biological evaluation. The synthesis is mild, short, and high yielding and suitable for a structure-activity relationship study.}}, author = {{Killander, Dan and Sterner, Olov}}, issn = {{1434-193X}}, keywords = {{Total synthesis; Natural products; Bioactive metabolites; Cross-coupling; Oxygen heterocycles}}, language = {{eng}}, number = {{8}}, pages = {{1594--1596}}, publisher = {{John Wiley & Sons Inc.}}, series = {{European Journal of Organic Chemistry}}, title = {{Synthesis of the Bioactive Benzochromenes Pulchrol and Pulchral, Metabolites of Bourreria pulchra}}, url = {{http://dx.doi.org/10.1002/ejoc.201301792}}, doi = {{10.1002/ejoc.201301792}}, volume = {{2014}}, year = {{2014}}, }