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Multispectral guided fluorescence diffuse optical tomography using upconverting nanoparticles

Svenmarker, Pontus LU ; Xu, Can LU ; Liu, Haichun LU ; Wu, Xia and Andersson-Engels, Stefan LU (2014) In Applied Physics Letters 104(7).
Abstract
We report on improved image detectability for fluorescence diffuse optical tomography using upconverting nanoparticles doped with rare-earth elements. Core-shell NaYF4 : Yb3+/Er3+ @ NaYF4 upconverting nanoparticles were synthesized through a stoichiometric method. The Yb3+/Er3+ sensitizer-activator pair yielded two anti-Stokes shifted fluorescence emission bands at 540 nm and 660 nm, here used to a priori estimate the fluorescence source depth with sub-millimeter precision. A spatially varying regularization incorporated the a priori fluorescence source depth estimation into the tomography reconstruction scheme. Tissue phantom experiments showed both an improved resolution and contrast in the reconstructed images as compared to not using... (More)
We report on improved image detectability for fluorescence diffuse optical tomography using upconverting nanoparticles doped with rare-earth elements. Core-shell NaYF4 : Yb3+/Er3+ @ NaYF4 upconverting nanoparticles were synthesized through a stoichiometric method. The Yb3+/Er3+ sensitizer-activator pair yielded two anti-Stokes shifted fluorescence emission bands at 540 nm and 660 nm, here used to a priori estimate the fluorescence source depth with sub-millimeter precision. A spatially varying regularization incorporated the a priori fluorescence source depth estimation into the tomography reconstruction scheme. Tissue phantom experiments showed both an improved resolution and contrast in the reconstructed images as compared to not using any a priori information. (C) 2014 AIP Publishing LLC. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Applied Physics Letters
volume
104
issue
7
publisher
American Institute of Physics
external identifiers
  • wos:000332038500085
  • scopus:84897455903
ISSN
0003-6951
DOI
10.1063/1.4863960
language
English
LU publication?
yes
id
b2d2af65-b6b0-4142-8e1d-036d2463e3e2 (old id 4418862)
date added to LUP
2014-05-05 11:00:12
date last changed
2017-01-15 03:18:35
@article{b2d2af65-b6b0-4142-8e1d-036d2463e3e2,
  abstract     = {We report on improved image detectability for fluorescence diffuse optical tomography using upconverting nanoparticles doped with rare-earth elements. Core-shell NaYF4 : Yb3+/Er3+ @ NaYF4 upconverting nanoparticles were synthesized through a stoichiometric method. The Yb3+/Er3+ sensitizer-activator pair yielded two anti-Stokes shifted fluorescence emission bands at 540 nm and 660 nm, here used to a priori estimate the fluorescence source depth with sub-millimeter precision. A spatially varying regularization incorporated the a priori fluorescence source depth estimation into the tomography reconstruction scheme. Tissue phantom experiments showed both an improved resolution and contrast in the reconstructed images as compared to not using any a priori information. (C) 2014 AIP Publishing LLC.},
  articleno    = {073703},
  author       = {Svenmarker, Pontus and Xu, Can and Liu, Haichun and Wu, Xia and Andersson-Engels, Stefan},
  issn         = {0003-6951},
  language     = {eng},
  number       = {7},
  publisher    = {American Institute of Physics},
  series       = {Applied Physics Letters},
  title        = {Multispectral guided fluorescence diffuse optical tomography using upconverting nanoparticles},
  url          = {http://dx.doi.org/10.1063/1.4863960},
  volume       = {104},
  year         = {2014},
}