Advanced

Brain natriuretic peptide is a potent vasodilator in aged human microcirculation and shows a blunted response in heart failure patients.

Edvinsson, MarieLouise LU ; Uddman, Erik LU ; Edvinsson, Lars LU and Andersson, Sven LU (2014) In Journal of geriatric cardiology : JGC 11(1). p.50-56
Abstract
Brain natriuretic peptide (BNP) is normally present in low levels in the circulation, but it is elevated in parallel with the degree of congestion in heart failure subjects (CHF). BNP has natriuretic effects and is a potent vasodilator. It is suggested that BNP could be a therapeutic alternative in CHF. However, we postulated that the high levels of circulating BNP in CHF may downregulate the response of microvascular natriuretic receptors. This was tested by comparing 15 CHF patients (BNP > 3000 ng/L) with 10 matched, healthy controls.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of geriatric cardiology : JGC
volume
11
issue
1
pages
50 - 56
publisher
Science Press
external identifiers
  • pmid:24748882
  • wos:000334078700008
  • scopus:84902267895
ISSN
1671-5411
DOI
10.3969/j.issn.1671-5411.2014.01.004
language
English
LU publication?
yes
id
d2320a79-8992-44d3-9031-5e4f30e93db0 (old id 4429730)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24748882?dopt=Abstract
date added to LUP
2014-05-04 23:49:25
date last changed
2017-08-20 04:00:43
@article{d2320a79-8992-44d3-9031-5e4f30e93db0,
  abstract     = {Brain natriuretic peptide (BNP) is normally present in low levels in the circulation, but it is elevated in parallel with the degree of congestion in heart failure subjects (CHF). BNP has natriuretic effects and is a potent vasodilator. It is suggested that BNP could be a therapeutic alternative in CHF. However, we postulated that the high levels of circulating BNP in CHF may downregulate the response of microvascular natriuretic receptors. This was tested by comparing 15 CHF patients (BNP > 3000 ng/L) with 10 matched, healthy controls.},
  author       = {Edvinsson, MarieLouise and Uddman, Erik and Edvinsson, Lars and Andersson, Sven},
  issn         = {1671-5411},
  language     = {eng},
  number       = {1},
  pages        = {50--56},
  publisher    = {Science Press},
  series       = {Journal of geriatric cardiology : JGC},
  title        = {Brain natriuretic peptide is a potent vasodilator in aged human microcirculation and shows a blunted response in heart failure patients.},
  url          = {http://dx.doi.org/10.3969/j.issn.1671-5411.2014.01.004},
  volume       = {11},
  year         = {2014},
}