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Maternal hypothyroidism in early pregnancy and infant structural congenital malformations.

Källén, Bengt LU and Norstedt Wikner, Birgitta (2014) In Journal of Thyroid Research 2014(Mar 12).
Abstract
Background. The question is debated on whether maternal hypothyroidism or use of thyroxin in early pregnancy affects the risk for infant congenital malformations. Objectives. To expand the previously published study on maternal thyroxin use in early pregnancy and the risk for congenital malformations. Methods. Data from the Swedish Medical Birth Register were used for the years 1996-2011 and infant malformations were identified from national health registers. Women with preexisting diabetes or reporting the use of thyreostatics, anticonvulsants, or antihypertensives were excluded from analysis. Risk estimates were made as odds ratios (ORs) or risk ratios (RRs) after adjustment for year of delivery, maternal age, parity, smoking, and body... (More)
Background. The question is debated on whether maternal hypothyroidism or use of thyroxin in early pregnancy affects the risk for infant congenital malformations. Objectives. To expand the previously published study on maternal thyroxin use in early pregnancy and the risk for congenital malformations. Methods. Data from the Swedish Medical Birth Register were used for the years 1996-2011 and infant malformations were identified from national health registers. Women with preexisting diabetes or reporting the use of thyreostatics, anticonvulsants, or antihypertensives were excluded from analysis. Risk estimates were made as odds ratios (ORs) or risk ratios (RRs) after adjustment for year of delivery, maternal age, parity, smoking, and body mass index. Results. Among 23 259 infants whose mothers in early pregnancy used thyroxin, 730 had a major malformation; among all 1 567 736 infants, 48012 had such malformations. The adjusted OR was 1.06 (95% CI 0.98-1.14). For anal atresia the RR was 1.85 (95% CI 1.00-1.85) and for choanal atresia 3.14 (95% CI 1.26-6.47). The risk of some other malformations was also increased but statistical significance was not reached. Conclusions. Treated maternal hypothyroidism may be a weak risk factor for infant congenital malformations but an association with a few rare conditions is possible. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Thyroid Research
volume
2014
issue
Mar 12
publisher
Hindawi Publishing Corporation
external identifiers
  • pmid:24744955
  • scopus:84897531302
ISSN
2090-8067
DOI
10.1155/2014/160780
language
English
LU publication?
yes
id
31c3c9d1-86f7-417f-bcaa-e72e4be148ad (old id 4429886)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24744955?dopt=Abstract
date added to LUP
2014-05-05 17:31:04
date last changed
2017-02-22 10:46:36
@article{31c3c9d1-86f7-417f-bcaa-e72e4be148ad,
  abstract     = {Background. The question is debated on whether maternal hypothyroidism or use of thyroxin in early pregnancy affects the risk for infant congenital malformations. Objectives. To expand the previously published study on maternal thyroxin use in early pregnancy and the risk for congenital malformations. Methods. Data from the Swedish Medical Birth Register were used for the years 1996-2011 and infant malformations were identified from national health registers. Women with preexisting diabetes or reporting the use of thyreostatics, anticonvulsants, or antihypertensives were excluded from analysis. Risk estimates were made as odds ratios (ORs) or risk ratios (RRs) after adjustment for year of delivery, maternal age, parity, smoking, and body mass index. Results. Among 23 259 infants whose mothers in early pregnancy used thyroxin, 730 had a major malformation; among all 1 567 736 infants, 48012 had such malformations. The adjusted OR was 1.06 (95% CI 0.98-1.14). For anal atresia the RR was 1.85 (95% CI 1.00-1.85) and for choanal atresia 3.14 (95% CI 1.26-6.47). The risk of some other malformations was also increased but statistical significance was not reached. Conclusions. Treated maternal hypothyroidism may be a weak risk factor for infant congenital malformations but an association with a few rare conditions is possible.},
  articleno    = {160780},
  author       = {Källén, Bengt and Norstedt Wikner, Birgitta},
  issn         = {2090-8067},
  language     = {eng},
  number       = {Mar 12},
  publisher    = {Hindawi Publishing Corporation},
  series       = {Journal of Thyroid Research},
  title        = {Maternal hypothyroidism in early pregnancy and infant structural congenital malformations.},
  url          = {http://dx.doi.org/10.1155/2014/160780},
  volume       = {2014},
  year         = {2014},
}