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Serum estradiol associates with blood hemoglobin in elderly men; The MrOS Sweden Study.

Lewerin, Catharina; Nilsson-Ehle, Herman; Jacobsson, Stefan; Johansson, Helena; Sundh, Valter; Karlsson, Magnus LU ; Lorentzon, Mattias; Barrett-Connor, Elizabeth; Vandenput, Liesbeth and Ohlsson, Claes, et al. (2014) In Journal of Clinical Endocrinology and Metabolism 99(7). p.2549-2556
Abstract
Context: Blood hemoglobin (Hb) declines with age in healthy elderly men, in whom decreasing testosterone has been regarded as part of normal ageing. However, the association between Hb and serum estradiol is incompletely known. Objective: To determine whether estradiol is associated with anemia/Hb and established determinants of Hb in elderly men without prostate cancer. Design, Setting and Participants: The MrOS (Osteoporotic Fractures in Men) is a population-based study (n=918, median age 75.3 years, range 70-81 years). Main Outcome Measures: We evaluated total estradiol in relation to Hb and adjusted for potential confounders (i.e. age, body mass index (BMI), erythropoietin (EPO), total testosterone, cystatin C, iron- and B-vitamin... (More)
Context: Blood hemoglobin (Hb) declines with age in healthy elderly men, in whom decreasing testosterone has been regarded as part of normal ageing. However, the association between Hb and serum estradiol is incompletely known. Objective: To determine whether estradiol is associated with anemia/Hb and established determinants of Hb in elderly men without prostate cancer. Design, Setting and Participants: The MrOS (Osteoporotic Fractures in Men) is a population-based study (n=918, median age 75.3 years, range 70-81 years). Main Outcome Measures: We evaluated total estradiol in relation to Hb and adjusted for potential confounders (i.e. age, body mass index (BMI), erythropoietin (EPO), total testosterone, cystatin C, iron- and B-vitamin status). Results: Estradiol correlated negatively with age (r=-0.14, p<0.001). Hb correlated (age adjusted) positively with estradiol (r=0.21, p<0.001) and testosterone (r=0.10, p<0.01). Independent predictors for Hb in multivariate analyses were estradiol, EPO, BMI, transferrin saturation, cystatin C and free T4 but not testosterone. After exclusion of subjects with Hb <130g/L and/or testosterone <8 nmol/L (n=99), the correlation between Hb and testosterone was no longer significant, whereas the associations between Hb and estradiol remained. After adjusting for age, BMI and EPO, men with lower estradiol levels were more likely to have Hb in the lowest quartile of values [OR per SD decrease in estradiol = 1.61 (95% CI 1.34-1.93)]. Anemic subjects (Hb <130 g/L) had lower mean estradiol than non-anemic (67.4 vs 79.4 pmol/L, p<0.001). Conclusions: Estradiol correlated, positively and independently, with Hb. Decreased estradiol might partly explain the age-related Hb decline observed in healthy elderly men. (Less)
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published
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Journal of Clinical Endocrinology and Metabolism
volume
99
issue
7
pages
2549 - 2556
publisher
The Endocrine Society
external identifiers
  • pmid:24731011
  • wos:000342341000064
  • scopus:84904035131
ISSN
1945-7197
DOI
10.1210/jc.2013-4111
language
English
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yes
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3f65f0a8-8190-4e2a-a65f-588286f2ef09 (old id 4430102)
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http://www.ncbi.nlm.nih.gov/pubmed/24731011?dopt=Abstract
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2014-05-05 20:05:57
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2017-08-20 03:26:14
@article{3f65f0a8-8190-4e2a-a65f-588286f2ef09,
  abstract     = {Context: Blood hemoglobin (Hb) declines with age in healthy elderly men, in whom decreasing testosterone has been regarded as part of normal ageing. However, the association between Hb and serum estradiol is incompletely known. Objective: To determine whether estradiol is associated with anemia/Hb and established determinants of Hb in elderly men without prostate cancer. Design, Setting and Participants: The MrOS (Osteoporotic Fractures in Men) is a population-based study (n=918, median age 75.3 years, range 70-81 years). Main Outcome Measures: We evaluated total estradiol in relation to Hb and adjusted for potential confounders (i.e. age, body mass index (BMI), erythropoietin (EPO), total testosterone, cystatin C, iron- and B-vitamin status). Results: Estradiol correlated negatively with age (r=-0.14, p&lt;0.001). Hb correlated (age adjusted) positively with estradiol (r=0.21, p&lt;0.001) and testosterone (r=0.10, p&lt;0.01). Independent predictors for Hb in multivariate analyses were estradiol, EPO, BMI, transferrin saturation, cystatin C and free T4 but not testosterone. After exclusion of subjects with Hb &lt;130g/L and/or testosterone &lt;8 nmol/L (n=99), the correlation between Hb and testosterone was no longer significant, whereas the associations between Hb and estradiol remained. After adjusting for age, BMI and EPO, men with lower estradiol levels were more likely to have Hb in the lowest quartile of values [OR per SD decrease in estradiol = 1.61 (95% CI 1.34-1.93)]. Anemic subjects (Hb &lt;130 g/L) had lower mean estradiol than non-anemic (67.4 vs 79.4 pmol/L, p&lt;0.001). Conclusions: Estradiol correlated, positively and independently, with Hb. Decreased estradiol might partly explain the age-related Hb decline observed in healthy elderly men.},
  author       = {Lewerin, Catharina and Nilsson-Ehle, Herman and Jacobsson, Stefan and Johansson, Helena and Sundh, Valter and Karlsson, Magnus and Lorentzon, Mattias and Barrett-Connor, Elizabeth and Vandenput, Liesbeth and Ohlsson, Claes and Mellström, Dan},
  issn         = {1945-7197},
  language     = {eng},
  number       = {7},
  pages        = {2549--2556},
  publisher    = {The Endocrine Society},
  series       = {Journal of Clinical Endocrinology and Metabolism},
  title        = {Serum estradiol associates with blood hemoglobin in elderly men; The MrOS Sweden Study.},
  url          = {http://dx.doi.org/10.1210/jc.2013-4111},
  volume       = {99},
  year         = {2014},
}