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Serum estradiol associates with blood hemoglobin in elderly men; The MrOS Sweden Study.

Lewerin, Catharina ; Nilsson-Ehle, Herman ; Jacobsson, Stefan ; Johansson, Helena ; Sundh, Valter ; Karlsson, Magnus LU ; Lorentzon, Mattias ; Barrett-Connor, Elizabeth ; Vandenput, Liesbeth and Ohlsson, Claes , et al. (2014) In Journal of Clinical Endocrinology and Metabolism 99(7). p.2549-2556
Abstract
Context: Blood hemoglobin (Hb) declines with age in healthy elderly men, in whom decreasing testosterone has been regarded as part of normal ageing. However, the association between Hb and serum estradiol is incompletely known. Objective: To determine whether estradiol is associated with anemia/Hb and established determinants of Hb in elderly men without prostate cancer. Design, Setting and Participants: The MrOS (Osteoporotic Fractures in Men) is a population-based study (n=918, median age 75.3 years, range 70-81 years). Main Outcome Measures: We evaluated total estradiol in relation to Hb and adjusted for potential confounders (i.e. age, body mass index (BMI), erythropoietin (EPO), total testosterone, cystatin C, iron- and B-vitamin... (More)
Context: Blood hemoglobin (Hb) declines with age in healthy elderly men, in whom decreasing testosterone has been regarded as part of normal ageing. However, the association between Hb and serum estradiol is incompletely known. Objective: To determine whether estradiol is associated with anemia/Hb and established determinants of Hb in elderly men without prostate cancer. Design, Setting and Participants: The MrOS (Osteoporotic Fractures in Men) is a population-based study (n=918, median age 75.3 years, range 70-81 years). Main Outcome Measures: We evaluated total estradiol in relation to Hb and adjusted for potential confounders (i.e. age, body mass index (BMI), erythropoietin (EPO), total testosterone, cystatin C, iron- and B-vitamin status). Results: Estradiol correlated negatively with age (r=-0.14, p<0.001). Hb correlated (age adjusted) positively with estradiol (r=0.21, p<0.001) and testosterone (r=0.10, p<0.01). Independent predictors for Hb in multivariate analyses were estradiol, EPO, BMI, transferrin saturation, cystatin C and free T4 but not testosterone. After exclusion of subjects with Hb <130g/L and/or testosterone <8 nmol/L (n=99), the correlation between Hb and testosterone was no longer significant, whereas the associations between Hb and estradiol remained. After adjusting for age, BMI and EPO, men with lower estradiol levels were more likely to have Hb in the lowest quartile of values [OR per SD decrease in estradiol = 1.61 (95% CI 1.34-1.93)]. Anemic subjects (Hb <130 g/L) had lower mean estradiol than non-anemic (67.4 vs 79.4 pmol/L, p<0.001). Conclusions: Estradiol correlated, positively and independently, with Hb. Decreased estradiol might partly explain the age-related Hb decline observed in healthy elderly men. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Clinical Endocrinology and Metabolism
volume
99
issue
7
pages
2549 - 2556
publisher
Oxford University Press
external identifiers
  • pmid:24731011
  • wos:000342341000064
  • scopus:84904035131
  • pmid:24731011
ISSN
1945-7197
DOI
10.1210/jc.2013-4111
language
English
LU publication?
yes
id
3f65f0a8-8190-4e2a-a65f-588286f2ef09 (old id 4430102)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24731011?dopt=Abstract
date added to LUP
2016-04-01 11:12:52
date last changed
2021-09-22 05:51:34
@article{3f65f0a8-8190-4e2a-a65f-588286f2ef09,
  abstract     = {Context: Blood hemoglobin (Hb) declines with age in healthy elderly men, in whom decreasing testosterone has been regarded as part of normal ageing. However, the association between Hb and serum estradiol is incompletely known. Objective: To determine whether estradiol is associated with anemia/Hb and established determinants of Hb in elderly men without prostate cancer. Design, Setting and Participants: The MrOS (Osteoporotic Fractures in Men) is a population-based study (n=918, median age 75.3 years, range 70-81 years). Main Outcome Measures: We evaluated total estradiol in relation to Hb and adjusted for potential confounders (i.e. age, body mass index (BMI), erythropoietin (EPO), total testosterone, cystatin C, iron- and B-vitamin status). Results: Estradiol correlated negatively with age (r=-0.14, p&lt;0.001). Hb correlated (age adjusted) positively with estradiol (r=0.21, p&lt;0.001) and testosterone (r=0.10, p&lt;0.01). Independent predictors for Hb in multivariate analyses were estradiol, EPO, BMI, transferrin saturation, cystatin C and free T4 but not testosterone. After exclusion of subjects with Hb &lt;130g/L and/or testosterone &lt;8 nmol/L (n=99), the correlation between Hb and testosterone was no longer significant, whereas the associations between Hb and estradiol remained. After adjusting for age, BMI and EPO, men with lower estradiol levels were more likely to have Hb in the lowest quartile of values [OR per SD decrease in estradiol = 1.61 (95% CI 1.34-1.93)]. Anemic subjects (Hb &lt;130 g/L) had lower mean estradiol than non-anemic (67.4 vs 79.4 pmol/L, p&lt;0.001). Conclusions: Estradiol correlated, positively and independently, with Hb. Decreased estradiol might partly explain the age-related Hb decline observed in healthy elderly men.},
  author       = {Lewerin, Catharina and Nilsson-Ehle, Herman and Jacobsson, Stefan and Johansson, Helena and Sundh, Valter and Karlsson, Magnus and Lorentzon, Mattias and Barrett-Connor, Elizabeth and Vandenput, Liesbeth and Ohlsson, Claes and Mellström, Dan},
  issn         = {1945-7197},
  language     = {eng},
  number       = {7},
  pages        = {2549--2556},
  publisher    = {Oxford University Press},
  series       = {Journal of Clinical Endocrinology and Metabolism},
  title        = {Serum estradiol associates with blood hemoglobin in elderly men; The MrOS Sweden Study.},
  url          = {https://lup.lub.lu.se/search/files/2478093/4762146},
  doi          = {10.1210/jc.2013-4111},
  volume       = {99},
  year         = {2014},
}