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Human endogenous peptide p33 inhibits detrimental effects of LL-37 on osteoblast viability.

Svensson, Daniel LU ; Westman, Johannes LU ; Wickström, Claes LU ; Jönsson, Daniel LU ; Herwald, Heiko LU and Nilsson, Bengt-Olof LU (2015) In Journal of Periodontal Research 50(1). p.80-88
Abstract
High levels of the antimicrobial peptide, LL-37, are detected in gingival crevicular fluid from patients with chronic periodontitis. LL-37 not only shows antimicrobial activity but also affects host-cell viability. The objective of the present study was to identify endogenous mechanisms that antagonize the detrimental effects of LL-37 on osteoblast viability, focusing on the human peptide p33 expressed on the surface of various cell types.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Periodontal Research
volume
50
issue
1
pages
80 - 88
publisher
Wiley-Blackwell
external identifiers
  • pmid:24697598
  • wos:000347467600010
  • scopus:84920800294
ISSN
1600-0765
DOI
10.1111/jre.12184
language
English
LU publication?
yes
id
d4cbf236-5a7e-4b71-96c5-75f1e8980ae1 (old id 4431137)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24697598?dopt=Abstract
date added to LUP
2014-05-06 21:28:57
date last changed
2017-10-22 03:13:38
@article{d4cbf236-5a7e-4b71-96c5-75f1e8980ae1,
  abstract     = {High levels of the antimicrobial peptide, LL-37, are detected in gingival crevicular fluid from patients with chronic periodontitis. LL-37 not only shows antimicrobial activity but also affects host-cell viability. The objective of the present study was to identify endogenous mechanisms that antagonize the detrimental effects of LL-37 on osteoblast viability, focusing on the human peptide p33 expressed on the surface of various cell types.},
  author       = {Svensson, Daniel and Westman, Johannes and Wickström, Claes and Jönsson, Daniel and Herwald, Heiko and Nilsson, Bengt-Olof},
  issn         = {1600-0765},
  language     = {eng},
  number       = {1},
  pages        = {80--88},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of Periodontal Research},
  title        = {Human endogenous peptide p33 inhibits detrimental effects of LL-37 on osteoblast viability.},
  url          = {http://dx.doi.org/10.1111/jre.12184},
  volume       = {50},
  year         = {2015},
}