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Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium.

Koivula, Robert LU ; Heggie, Alison; Barnett, Anna; Cederberg, Henna; Hansen, Tue H; Koopman, Anitra D; Ridderstråle, Martin LU ; Rutters, Femke; Vestergaard, Henrik and Gupta, Ramneek, et al. (2014) In Diabetologia 57(6). p.1132-1142
Abstract
The DIRECT (Diabetes Research on Patient Stratification) Study is part of a European Union Framework 7 Innovative Medicines Initiative project, a joint undertaking between four industry and 21 academic partners throughout Europe. The Consortium aims to discover and validate biomarkers that: (1) predict the rate of glycaemic deterioration before and after type 2 diabetes onset; (2) predict the response to diabetes therapies; and (3) help stratify type 2 diabetes into clearly definable disease subclasses that can be treated more effectively than without stratification. This paper describes two new prospective cohort studies conducted as part of DIRECT.
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@article{a23d1af8-b6e9-4f25-b9d9-388f6a45ccb7,
  abstract     = {The DIRECT (Diabetes Research on Patient Stratification) Study is part of a European Union Framework 7 Innovative Medicines Initiative project, a joint undertaking between four industry and 21 academic partners throughout Europe. The Consortium aims to discover and validate biomarkers that: (1) predict the rate of glycaemic deterioration before and after type 2 diabetes onset; (2) predict the response to diabetes therapies; and (3) help stratify type 2 diabetes into clearly definable disease subclasses that can be treated more effectively than without stratification. This paper describes two new prospective cohort studies conducted as part of DIRECT.},
  author       = {Koivula, Robert and Heggie, Alison and Barnett, Anna and Cederberg, Henna and Hansen, Tue H and Koopman, Anitra D and Ridderstråle, Martin and Rutters, Femke and Vestergaard, Henrik and Gupta, Ramneek and Herrgård, Sanna and Heymans, Martijn W and Perry, Mandy H and Rauh, Simone and Siloaho, Maritta and Teare, Harriet J A and Thorand, Barbara and Bell, Jimmy and Brunak, Søren and Frost, Gary and Jablonka, Bernd and Mari, Andrea and McDonald, Tim J and Dekker, Jacqueline M and Hansen, Torben and Hattersley, Andrew and Laakso, Markku and Pedersen, Oluf and Koivisto, Veikko and Ruetten, Hartmut and Walker, Mark and Pearson, Ewan and Franks, Paul},
  issn         = {1432-0428},
  language     = {eng},
  number       = {6},
  pages        = {1132--1142},
  publisher    = {Springer Verlag},
  series       = {Diabetologia},
  title        = {Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium.},
  url          = {http://dx.doi.org/10.1007/s00125-014-3216-x},
  volume       = {57},
  year         = {2014},
}