Advanced

Efficacy of a once-a-week screening programme to control extended-spectrum beta-lactamase-producing bacteria in a neonatal intensive care unit.

Rybczynska, Helena; Melander, Eva LU ; Johansson, Hugo LU and Lundberg, Fredrik (2014) In Scandinavian Journal of Infectious Diseases 46(6). p.426-432
Abstract
Background: Extended-spectrum beta-lactamase (ESBL)-producing bacteria are an escalating problem threatening health. Devastating consequences can result in neonatal intensive care units (NICU) due to these bacteria. The aim of this study was to investigate the efficacy of once-a-week screening (July 2010 to September 2012) versus screening on demand (April 2008 to June 2010). Materials and methods: The investigation was an open retrospective descriptive study comparing 2 unpaired groups, the first exposed to screening on demand and the second to screening once a week. All other infection control measures were unchanged. Both groups were cared for in the NICU of Skåne University Hospital. Parameters compared were the proportion of cultured... (More)
Background: Extended-spectrum beta-lactamase (ESBL)-producing bacteria are an escalating problem threatening health. Devastating consequences can result in neonatal intensive care units (NICU) due to these bacteria. The aim of this study was to investigate the efficacy of once-a-week screening (July 2010 to September 2012) versus screening on demand (April 2008 to June 2010). Materials and methods: The investigation was an open retrospective descriptive study comparing 2 unpaired groups, the first exposed to screening on demand and the second to screening once a week. All other infection control measures were unchanged. Both groups were cared for in the NICU of Skåne University Hospital. Parameters compared were the proportion of cultured neonates, prevalence, time before detection, number of secondary cases, and clinical infections due to ESBL-producing bacteria. Results: The proportion of cultured neonates increased from 28% to 49% (p < 0.05) in period 2. The time from admission to detection was 8 days shorter in period 2 (p < 0.05). Secondary cases decreased from 44% to 9% (p < 0.05), and clinical infections from 4 to 0 cases (p < 0.05). During period 2, the prevalence of colonization was 1.77%. Conclusions: Once-a-week screening is a strategy to control the epidemiology of unwanted pathogens among newborn infants. It provides the opportunity for early intervention, thereby avoiding secondary cases and infections. Premature neonates in particular benefit from this approach. The prevalence of ESBL of 1.77% is low from an international perspective. ESBL appear to be introduced onto the ward by mothers colonized with ESBL. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Infectious Diseases
volume
46
issue
6
pages
426 - 432
publisher
Informa Healthcare
external identifiers
  • pmid:24689959
  • wos:000336454800004
  • scopus:84900838049
ISSN
1651-1980
DOI
10.3109/00365548.2014.896027
language
English
LU publication?
yes
id
effe9881-d8fa-427f-b4a3-1f8c362c8e64 (old id 4431343)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24689959?dopt=Abstract
date added to LUP
2014-05-07 18:37:41
date last changed
2017-07-09 03:02:52
@article{effe9881-d8fa-427f-b4a3-1f8c362c8e64,
  abstract     = {Background: Extended-spectrum beta-lactamase (ESBL)-producing bacteria are an escalating problem threatening health. Devastating consequences can result in neonatal intensive care units (NICU) due to these bacteria. The aim of this study was to investigate the efficacy of once-a-week screening (July 2010 to September 2012) versus screening on demand (April 2008 to June 2010). Materials and methods: The investigation was an open retrospective descriptive study comparing 2 unpaired groups, the first exposed to screening on demand and the second to screening once a week. All other infection control measures were unchanged. Both groups were cared for in the NICU of Skåne University Hospital. Parameters compared were the proportion of cultured neonates, prevalence, time before detection, number of secondary cases, and clinical infections due to ESBL-producing bacteria. Results: The proportion of cultured neonates increased from 28% to 49% (p &lt; 0.05) in period 2. The time from admission to detection was 8 days shorter in period 2 (p &lt; 0.05). Secondary cases decreased from 44% to 9% (p &lt; 0.05), and clinical infections from 4 to 0 cases (p &lt; 0.05). During period 2, the prevalence of colonization was 1.77%. Conclusions: Once-a-week screening is a strategy to control the epidemiology of unwanted pathogens among newborn infants. It provides the opportunity for early intervention, thereby avoiding secondary cases and infections. Premature neonates in particular benefit from this approach. The prevalence of ESBL of 1.77% is low from an international perspective. ESBL appear to be introduced onto the ward by mothers colonized with ESBL.},
  author       = {Rybczynska, Helena and Melander, Eva and Johansson, Hugo and Lundberg, Fredrik},
  issn         = {1651-1980},
  language     = {eng},
  number       = {6},
  pages        = {426--432},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Infectious Diseases},
  title        = {Efficacy of a once-a-week screening programme to control extended-spectrum beta-lactamase-producing bacteria in a neonatal intensive care unit.},
  url          = {http://dx.doi.org/10.3109/00365548.2014.896027},
  volume       = {46},
  year         = {2014},
}