Adiponutrin: A multimeric plasma protein.
(2014) In Biochemical and Biophysical Research Communications 446(4). p.1114-1119- Abstract
- The interest in adiponutrin stems from adiponutrin variant I148M, which is strongly associated to non-alcoholic fatty liver disease. Adiponutrin has to date been considered to be solely an intracellular protein, with a role in lipid metabolism in liver and adipose tissue. However, a physiologically relevant role for adiponutrin has not been found. The aim of this study was to investigate the presence of adiponutrin in human plasma, a new facet of adiponutrin research. We demonstrate that adiponutrin is present in plasma as disulfide-bond dependent multimers, estimated to circulate at a concentration of 1.25-4nM. Experiments reveal that adiponutrin is released from HepG2 cells in the presence of oleate. The presence of adiponutrin in plasma... (More)
- The interest in adiponutrin stems from adiponutrin variant I148M, which is strongly associated to non-alcoholic fatty liver disease. Adiponutrin has to date been considered to be solely an intracellular protein, with a role in lipid metabolism in liver and adipose tissue. However, a physiologically relevant role for adiponutrin has not been found. The aim of this study was to investigate the presence of adiponutrin in human plasma, a new facet of adiponutrin research. We demonstrate that adiponutrin is present in plasma as disulfide-bond dependent multimers, estimated to circulate at a concentration of 1.25-4nM. Experiments reveal that adiponutrin is released from HepG2 cells in the presence of oleate. The presence of adiponutrin in plasma makes it accessible for clinical investigations and use as a potential biomarker for metabolic disease. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4431533
- author
- Tinnerfelt Winberg, Martin LU ; Khalaj Motlagh, Mahshid LU ; Stenkula, Karin LU ; Holm, Cecilia LU and Jones, Helena LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Biochemical and Biophysical Research Communications
- volume
- 446
- issue
- 4
- pages
- 1114 - 1119
- publisher
- Elsevier
- external identifiers
-
- pmid:24680680
- wos:000335367900049
- scopus:84899493003
- pmid:24680680
- ISSN
- 1090-2104
- DOI
- 10.1016/j.bbrc.2014.03.078
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Molecular Endocrinology (013212018), Diabetes, Metabolism and Endocrinology (LUR000004)
- id
- 663e1c45-8230-4eb5-9a4f-dc521ec16880 (old id 4431533)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24680680?dopt=Abstract
- date added to LUP
- 2016-04-01 10:11:07
- date last changed
- 2022-04-12 02:50:42
@article{663e1c45-8230-4eb5-9a4f-dc521ec16880, abstract = {{The interest in adiponutrin stems from adiponutrin variant I148M, which is strongly associated to non-alcoholic fatty liver disease. Adiponutrin has to date been considered to be solely an intracellular protein, with a role in lipid metabolism in liver and adipose tissue. However, a physiologically relevant role for adiponutrin has not been found. The aim of this study was to investigate the presence of adiponutrin in human plasma, a new facet of adiponutrin research. We demonstrate that adiponutrin is present in plasma as disulfide-bond dependent multimers, estimated to circulate at a concentration of 1.25-4nM. Experiments reveal that adiponutrin is released from HepG2 cells in the presence of oleate. The presence of adiponutrin in plasma makes it accessible for clinical investigations and use as a potential biomarker for metabolic disease.}}, author = {{Tinnerfelt Winberg, Martin and Khalaj Motlagh, Mahshid and Stenkula, Karin and Holm, Cecilia and Jones, Helena}}, issn = {{1090-2104}}, language = {{eng}}, number = {{4}}, pages = {{1114--1119}}, publisher = {{Elsevier}}, series = {{Biochemical and Biophysical Research Communications}}, title = {{Adiponutrin: A multimeric plasma protein.}}, url = {{https://lup.lub.lu.se/search/files/1634368/4731767}}, doi = {{10.1016/j.bbrc.2014.03.078}}, volume = {{446}}, year = {{2014}}, }