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Adiponutrin: A multimeric plasma protein.

Tinnerfelt Winberg, Martin LU ; Khalaj Motlagh, Mahshid LU ; Stenkula, Karin LU ; Holm, Cecilia LU and Jones, Helena LU (2014) In Biochemical and Biophysical Research Communications 446(4). p.1114-1119
Abstract
The interest in adiponutrin stems from adiponutrin variant I148M, which is strongly associated to non-alcoholic fatty liver disease. Adiponutrin has to date been considered to be solely an intracellular protein, with a role in lipid metabolism in liver and adipose tissue. However, a physiologically relevant role for adiponutrin has not been found. The aim of this study was to investigate the presence of adiponutrin in human plasma, a new facet of adiponutrin research. We demonstrate that adiponutrin is present in plasma as disulfide-bond dependent multimers, estimated to circulate at a concentration of 1.25-4nM. Experiments reveal that adiponutrin is released from HepG2 cells in the presence of oleate. The presence of adiponutrin in plasma... (More)
The interest in adiponutrin stems from adiponutrin variant I148M, which is strongly associated to non-alcoholic fatty liver disease. Adiponutrin has to date been considered to be solely an intracellular protein, with a role in lipid metabolism in liver and adipose tissue. However, a physiologically relevant role for adiponutrin has not been found. The aim of this study was to investigate the presence of adiponutrin in human plasma, a new facet of adiponutrin research. We demonstrate that adiponutrin is present in plasma as disulfide-bond dependent multimers, estimated to circulate at a concentration of 1.25-4nM. Experiments reveal that adiponutrin is released from HepG2 cells in the presence of oleate. The presence of adiponutrin in plasma makes it accessible for clinical investigations and use as a potential biomarker for metabolic disease. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biochemical and Biophysical Research Communications
volume
446
issue
4
pages
1114 - 1119
publisher
Elsevier
external identifiers
  • pmid:24680680
  • wos:000335367900049
  • scopus:84899493003
ISSN
1090-2104
DOI
10.1016/j.bbrc.2014.03.078
language
English
LU publication?
yes
id
663e1c45-8230-4eb5-9a4f-dc521ec16880 (old id 4431533)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24680680?dopt=Abstract
date added to LUP
2014-05-08 08:30:57
date last changed
2017-04-16 03:06:17
@article{663e1c45-8230-4eb5-9a4f-dc521ec16880,
  abstract     = {The interest in adiponutrin stems from adiponutrin variant I148M, which is strongly associated to non-alcoholic fatty liver disease. Adiponutrin has to date been considered to be solely an intracellular protein, with a role in lipid metabolism in liver and adipose tissue. However, a physiologically relevant role for adiponutrin has not been found. The aim of this study was to investigate the presence of adiponutrin in human plasma, a new facet of adiponutrin research. We demonstrate that adiponutrin is present in plasma as disulfide-bond dependent multimers, estimated to circulate at a concentration of 1.25-4nM. Experiments reveal that adiponutrin is released from HepG2 cells in the presence of oleate. The presence of adiponutrin in plasma makes it accessible for clinical investigations and use as a potential biomarker for metabolic disease.},
  author       = {Tinnerfelt Winberg, Martin and Khalaj Motlagh, Mahshid and Stenkula, Karin and Holm, Cecilia and Jones, Helena},
  issn         = {1090-2104},
  language     = {eng},
  number       = {4},
  pages        = {1114--1119},
  publisher    = {Elsevier},
  series       = {Biochemical and Biophysical Research Communications},
  title        = {Adiponutrin: A multimeric plasma protein.},
  url          = {http://dx.doi.org/10.1016/j.bbrc.2014.03.078},
  volume       = {446},
  year         = {2014},
}