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Maternal obesity and risk of Down syndrome in the offspring

Hildebrand, Eric; Källén, Bengt LU ; Josefsson, Ann; Gottvall, Tomas and Blomberg, Marie (2014) In Prenatal Diagnosis 34(4). p.310-315
Abstract
Objective The objective of this article is to determine if maternal obesity is associated with an increased risk of Down syndrome in the offspring and whether the risk estimates for trisomy 21 based on combined screening is affected by maternal body mass index (BMI). Methods Study group I consisted of a nationwide cohort of 1 568 604 women giving birth; outcome was infants born with Down syndrome [Correction made here after initial online publication.]. Adjustment was made for maternal age. Study group II consisted of 10 224 women undergoing 1st trimester combined screening. Outcome was risk assessment for Down syndrome. All women were divided into six BMI groups, and outcomes were evaluated over the BMI strata with BMI 18.5 to 24.9 as... (More)
Objective The objective of this article is to determine if maternal obesity is associated with an increased risk of Down syndrome in the offspring and whether the risk estimates for trisomy 21 based on combined screening is affected by maternal body mass index (BMI). Methods Study group I consisted of a nationwide cohort of 1 568 604 women giving birth; outcome was infants born with Down syndrome [Correction made here after initial online publication.]. Adjustment was made for maternal age. Study group II consisted of 10 224 women undergoing 1st trimester combined screening. Outcome was risk assessment for Down syndrome. All women were divided into six BMI groups, and outcomes were evaluated over the BMI strata with BMI 18.5 to 24.9 as reference and correcting for maternal age. Results Obese women had an increased risk for giving birth to an infant with Down syndrome compared with normal-weight women, BMI 30 to 34.9 odds ratio (OR) 1.31 [95% confidence interval (CI) 1.10-1.55], BMI 35 to 39.9 OR 1.12 (95% CI 0.82-1.53), BMI >= 40 OR 1.56 (95% CI 1.00-2.43). The observed and the expected numbers of women with a risk of Down syndrome >1/300 based on 1st trimester combined screen and maternal age were similar in each BMI group. Conclusion Maternal obesity seems to increase the risk for Down syndrome births. The risk estimate for Down syndrome with 1st trimester combined screening is unaffected by BMI. (c) 2013 John Wiley & Sons, Ltd. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Prenatal Diagnosis
volume
34
issue
4
pages
310 - 315
publisher
John Wiley and Sons Ltd
external identifiers
  • wos:000334443000002
  • scopus:84898057520
ISSN
1097-0223
DOI
10.1002/pd.4294
language
English
LU publication?
yes
id
3e3a209d-2bc4-4110-a44c-5af5cd490ddd (old id 4439745)
date added to LUP
2014-07-01 07:44:53
date last changed
2017-05-28 03:16:22
@article{3e3a209d-2bc4-4110-a44c-5af5cd490ddd,
  abstract     = {Objective The objective of this article is to determine if maternal obesity is associated with an increased risk of Down syndrome in the offspring and whether the risk estimates for trisomy 21 based on combined screening is affected by maternal body mass index (BMI). Methods Study group I consisted of a nationwide cohort of 1 568 604 women giving birth; outcome was infants born with Down syndrome [Correction made here after initial online publication.]. Adjustment was made for maternal age. Study group II consisted of 10 224 women undergoing 1st trimester combined screening. Outcome was risk assessment for Down syndrome. All women were divided into six BMI groups, and outcomes were evaluated over the BMI strata with BMI 18.5 to 24.9 as reference and correcting for maternal age. Results Obese women had an increased risk for giving birth to an infant with Down syndrome compared with normal-weight women, BMI 30 to 34.9 odds ratio (OR) 1.31 [95% confidence interval (CI) 1.10-1.55], BMI 35 to 39.9 OR 1.12 (95% CI 0.82-1.53), BMI >= 40 OR 1.56 (95% CI 1.00-2.43). The observed and the expected numbers of women with a risk of Down syndrome >1/300 based on 1st trimester combined screen and maternal age were similar in each BMI group. Conclusion Maternal obesity seems to increase the risk for Down syndrome births. The risk estimate for Down syndrome with 1st trimester combined screening is unaffected by BMI. (c) 2013 John Wiley & Sons, Ltd.},
  author       = {Hildebrand, Eric and Källén, Bengt and Josefsson, Ann and Gottvall, Tomas and Blomberg, Marie},
  issn         = {1097-0223},
  language     = {eng},
  number       = {4},
  pages        = {310--315},
  publisher    = {John Wiley and Sons Ltd},
  series       = {Prenatal Diagnosis},
  title        = {Maternal obesity and risk of Down syndrome in the offspring},
  url          = {http://dx.doi.org/10.1002/pd.4294},
  volume       = {34},
  year         = {2014},
}