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Environmental influences on familial resemblance for drug abuse in first-cousin pairs: a Swedish national study

Kendler, K. S.; Ohlsson, Henrik LU ; Sundquist, Kristina LU and Sundquist, Jan LU (2014) In Psychological Medicine 44(2). p.371-379
Abstract
Background Using three independent methods, prior studies in Swedish sibling pairs indicate that environmental factors contribute substantially to familial aggregation for drug abuse (DA). Could we replicate these results in cousin pairs? Method Using multiple Swedish public databases (1964-2011), we defined DA using medical, legal or pharmacy registry records and examined concordance in full cousin pairs as a function of age differences, younger-older relationships and geographical proximity while growing up. Results Replicating prior results in siblings, cousin pairs were significantly more similar in their history of DA if they were (i) closer versus more distant in age and (ii) grew up in high versus low geographical proximity to one... (More)
Background Using three independent methods, prior studies in Swedish sibling pairs indicate that environmental factors contribute substantially to familial aggregation for drug abuse (DA). Could we replicate these results in cousin pairs? Method Using multiple Swedish public databases (1964-2011), we defined DA using medical, legal or pharmacy registry records and examined concordance in full cousin pairs as a function of age differences, younger-older relationships and geographical proximity while growing up. Results Replicating prior results in siblings, cousin pairs were significantly more similar in their history of DA if they were (i) closer versus more distant in age and (ii) grew up in high versus low geographical proximity to one another. Furthermore, controlling for background factors, having an older cousin with DA conveys a greater risk for DA than having a younger drug-abusing cousin. The greater transmission of DA from older to younger versus younger to older cousin was more prominent in pairs who grew up close to one another. In age difference and geographical proximity analyses, effects were consistently strongest in male-male cousin pairs. In analyses of older -> younger versus younger -> older transmission, effects were stronger in male-male and male-female than in female-female or female-male relative pairs. Conclusions In accord with prior results in siblings, environmental factors contribute substantially to the familial aggregation of DA in cousins and these effects are, in general, stronger in males than in females. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Sweden, Drug abuse, environmental transmission, epidemiology, genetics
in
Psychological Medicine
volume
44
issue
2
pages
371 - 379
publisher
Cambridge University Press
external identifiers
  • wos:000332382900014
  • scopus:84890696177
ISSN
1469-8978
DOI
10.1017/S0033291713000846
language
English
LU publication?
yes
id
ed25d5d4-e4c5-44af-bf87-e006ed7e2f9f (old id 4442901)
date added to LUP
2014-05-28 09:20:29
date last changed
2017-01-01 03:22:32
@article{ed25d5d4-e4c5-44af-bf87-e006ed7e2f9f,
  abstract     = {Background Using three independent methods, prior studies in Swedish sibling pairs indicate that environmental factors contribute substantially to familial aggregation for drug abuse (DA). Could we replicate these results in cousin pairs? Method Using multiple Swedish public databases (1964-2011), we defined DA using medical, legal or pharmacy registry records and examined concordance in full cousin pairs as a function of age differences, younger-older relationships and geographical proximity while growing up. Results Replicating prior results in siblings, cousin pairs were significantly more similar in their history of DA if they were (i) closer versus more distant in age and (ii) grew up in high versus low geographical proximity to one another. Furthermore, controlling for background factors, having an older cousin with DA conveys a greater risk for DA than having a younger drug-abusing cousin. The greater transmission of DA from older to younger versus younger to older cousin was more prominent in pairs who grew up close to one another. In age difference and geographical proximity analyses, effects were consistently strongest in male-male cousin pairs. In analyses of older -> younger versus younger -> older transmission, effects were stronger in male-male and male-female than in female-female or female-male relative pairs. Conclusions In accord with prior results in siblings, environmental factors contribute substantially to the familial aggregation of DA in cousins and these effects are, in general, stronger in males than in females.},
  author       = {Kendler, K. S. and Ohlsson, Henrik and Sundquist, Kristina and Sundquist, Jan},
  issn         = {1469-8978},
  keyword      = {Sweden,Drug abuse,environmental transmission,epidemiology,genetics},
  language     = {eng},
  number       = {2},
  pages        = {371--379},
  publisher    = {Cambridge University Press},
  series       = {Psychological Medicine},
  title        = {Environmental influences on familial resemblance for drug abuse in first-cousin pairs: a Swedish national study},
  url          = {http://dx.doi.org/10.1017/S0033291713000846},
  volume       = {44},
  year         = {2014},
}