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Pharmacokinetic and biodistribution study following systemic administration of Fospeg - a Pegylated liposomal mTHPC formulation in a murine model

Xie, Haiyan LU ; Svenmarker, Pontus LU ; Axelsson, Johan LU ; Gräfe, Susanna; Kyriazi, Maria; Bendsöe, Niels LU ; Andersson-Engels, Stefan LU and Svanberg, Katarina LU (2015) In Journal of Biophotonics 8(1-2). p.142-152
Abstract (Swedish)
Abstract in Undetermined

Fospeg® is a newly developed photosensitizer formulation based on meso-tetra(hydroxyphenyl)chlorin (mTHPC), with hydrophilic liposomes to carry the hydrophobic photosensitizer to the target tissue. In this study the pharmacokinetics and biodistribution of Fospeg® were investigated by high performance liquid chromatography at various times (0.5-18 hours) following systemic i.v. administration. As a model an experimental HT29 colon tumor in NMRI nu/nu mice was employed. Our study indicates a higher plasma peak concentration, a longer circulation time and a better tumor-to-skin ratio than those of Foslip®, another liposomal mTHPC formulation. Data from ex vivo tissue fluorescence and reflectance... (More)
Abstract in Undetermined

Fospeg® is a newly developed photosensitizer formulation based on meso-tetra(hydroxyphenyl)chlorin (mTHPC), with hydrophilic liposomes to carry the hydrophobic photosensitizer to the target tissue. In this study the pharmacokinetics and biodistribution of Fospeg® were investigated by high performance liquid chromatography at various times (0.5-18 hours) following systemic i.v. administration. As a model an experimental HT29 colon tumor in NMRI nu/nu mice was employed. Our study indicates a higher plasma peak concentration, a longer circulation time and a better tumor-to-skin ratio than those of Foslip®, another liposomal mTHPC formulation. Data from ex vivo tissue fluorescence and reflectance imaging exhibit good correlation with chemical extraction. Our results have shown that optical imaging provides the potential for fluorophore quantification in biological tissues. (© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim). (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
mTHPC, Fospeg, liposomes, pharmacokinetics, biodistribution, high performance liquid chromatography, fluorescence imaging
in
Journal of Biophotonics
volume
8
issue
1-2
pages
142 - 152
publisher
John Wiley & Sons
external identifiers
  • pmid:24375973
  • wos:000348537900015
  • scopus:84921024716
ISSN
1864-063X
DOI
10.1002/jbio.201300133
language
English
LU publication?
yes
id
f1af96df-068d-4bde-9406-e96e3650702e (old id 4446690)
alternative location
http://onlinelibrary.wiley.com/doi/10.1002/jbio.201300133/abstract
date added to LUP
2014-05-20 23:21:51
date last changed
2017-02-26 03:01:58
@article{f1af96df-068d-4bde-9406-e96e3650702e,
  abstract     = {<b>Abstract in Undetermined</b><br/><br>
Fospeg® is a newly developed photosensitizer formulation based on meso-tetra(hydroxyphenyl)chlorin (mTHPC), with hydrophilic liposomes to carry the hydrophobic photosensitizer to the target tissue. In this study the pharmacokinetics and biodistribution of Fospeg® were investigated by high performance liquid chromatography at various times (0.5-18 hours) following systemic i.v. administration. As a model an experimental HT29 colon tumor in NMRI nu/nu mice was employed. Our study indicates a higher plasma peak concentration, a longer circulation time and a better tumor-to-skin ratio than those of Foslip®, another liposomal mTHPC formulation. Data from ex vivo tissue fluorescence and reflectance imaging exhibit good correlation with chemical extraction. Our results have shown that optical imaging provides the potential for fluorophore quantification in biological tissues. (© 2013 WILEY-VCH Verlag GmbH &amp; Co. KGaA, Weinheim).},
  author       = {Xie, Haiyan and Svenmarker, Pontus and Axelsson, Johan and Gräfe, Susanna and Kyriazi, Maria and Bendsöe, Niels and Andersson-Engels, Stefan and Svanberg, Katarina},
  issn         = {1864-063X},
  keyword      = {mTHPC,Fospeg,liposomes,pharmacokinetics,biodistribution,high performance liquid chromatography,fluorescence imaging},
  language     = {eng},
  number       = {1-2},
  pages        = {142--152},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Biophotonics},
  title        = {Pharmacokinetic and biodistribution study following systemic administration of Fospeg - a Pegylated liposomal mTHPC formulation in a murine model},
  url          = {http://dx.doi.org/10.1002/jbio.201300133},
  volume       = {8},
  year         = {2015},
}