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The complement system in systemic lupus erythematosus: an update.

Leffler, Jonatan LU ; Bengtsson, Anders LU and Blom, Anna LU (2014) In Annals of the Rheumatic Diseases 73(9). p.1601-1606
Abstract
The complement system plays a major role in the autoimmune disease, systemic lupus erythematosus (SLE). However, the role of complement in SLE is complex since it may both prevent and exacerbate the disease. In this review, we explore the latest findings in complement-focused research in SLE. C1q deficiency is the strongest genetic risk factor for SLE, although such deficiency is very rare. Various recently discovered genetic associations include mutations in the complement receptors 2 and 3 as well as complement inhibitors, the latter related to earlier onset of nephritis. Further, autoantibodies are a distinct feature of SLE that are produced as the result of an adaptive immune response and how complement can affect that response is also... (More)
The complement system plays a major role in the autoimmune disease, systemic lupus erythematosus (SLE). However, the role of complement in SLE is complex since it may both prevent and exacerbate the disease. In this review, we explore the latest findings in complement-focused research in SLE. C1q deficiency is the strongest genetic risk factor for SLE, although such deficiency is very rare. Various recently discovered genetic associations include mutations in the complement receptors 2 and 3 as well as complement inhibitors, the latter related to earlier onset of nephritis. Further, autoantibodies are a distinct feature of SLE that are produced as the result of an adaptive immune response and how complement can affect that response is also being reviewed. SLE generates numerous disease manifestations involving contributions from complement such as glomerulonephritis and the increased risk of thrombosis. Furthermore, since most of the complement system is present in plasma, complement is very accessible and may be suitable as biomarker for diagnosis or monitoring of disease activity. This review highlights the many roles of complement for SLE pathogenesis and how research has progressed during recent years. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
in
Annals of the Rheumatic Diseases
volume
73
issue
9
pages
1601 - 1606
publisher
British Medical Association
external identifiers
  • pmid:24845390
  • wos:000340723700009
  • scopus:84905191911
ISSN
1468-2060
DOI
10.1136/annrheumdis-2014-205287
language
English
LU publication?
yes
id
b2330b97-86f6-44be-abf5-b2a5490fc823 (old id 4454030)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24845390?dopt=Abstract
date added to LUP
2014-06-04 22:18:52
date last changed
2017-10-22 03:11:53
@article{b2330b97-86f6-44be-abf5-b2a5490fc823,
  abstract     = {The complement system plays a major role in the autoimmune disease, systemic lupus erythematosus (SLE). However, the role of complement in SLE is complex since it may both prevent and exacerbate the disease. In this review, we explore the latest findings in complement-focused research in SLE. C1q deficiency is the strongest genetic risk factor for SLE, although such deficiency is very rare. Various recently discovered genetic associations include mutations in the complement receptors 2 and 3 as well as complement inhibitors, the latter related to earlier onset of nephritis. Further, autoantibodies are a distinct feature of SLE that are produced as the result of an adaptive immune response and how complement can affect that response is also being reviewed. SLE generates numerous disease manifestations involving contributions from complement such as glomerulonephritis and the increased risk of thrombosis. Furthermore, since most of the complement system is present in plasma, complement is very accessible and may be suitable as biomarker for diagnosis or monitoring of disease activity. This review highlights the many roles of complement for SLE pathogenesis and how research has progressed during recent years.},
  author       = {Leffler, Jonatan and Bengtsson, Anders and Blom, Anna},
  issn         = {1468-2060},
  language     = {eng},
  number       = {9},
  pages        = {1601--1606},
  publisher    = {British Medical Association},
  series       = {Annals of the Rheumatic Diseases},
  title        = {The complement system in systemic lupus erythematosus: an update.},
  url          = {http://dx.doi.org/10.1136/annrheumdis-2014-205287},
  volume       = {73},
  year         = {2014},
}