The complement system in systemic lupus erythematosus: an update.
(2014) In Annals of the Rheumatic Diseases 73(9). p.1601-1606- Abstract
- The complement system plays a major role in the autoimmune disease, systemic lupus erythematosus (SLE). However, the role of complement in SLE is complex since it may both prevent and exacerbate the disease. In this review, we explore the latest findings in complement-focused research in SLE. C1q deficiency is the strongest genetic risk factor for SLE, although such deficiency is very rare. Various recently discovered genetic associations include mutations in the complement receptors 2 and 3 as well as complement inhibitors, the latter related to earlier onset of nephritis. Further, autoantibodies are a distinct feature of SLE that are produced as the result of an adaptive immune response and how complement can affect that response is also... (More)
- The complement system plays a major role in the autoimmune disease, systemic lupus erythematosus (SLE). However, the role of complement in SLE is complex since it may both prevent and exacerbate the disease. In this review, we explore the latest findings in complement-focused research in SLE. C1q deficiency is the strongest genetic risk factor for SLE, although such deficiency is very rare. Various recently discovered genetic associations include mutations in the complement receptors 2 and 3 as well as complement inhibitors, the latter related to earlier onset of nephritis. Further, autoantibodies are a distinct feature of SLE that are produced as the result of an adaptive immune response and how complement can affect that response is also being reviewed. SLE generates numerous disease manifestations involving contributions from complement such as glomerulonephritis and the increased risk of thrombosis. Furthermore, since most of the complement system is present in plasma, complement is very accessible and may be suitable as biomarker for diagnosis or monitoring of disease activity. This review highlights the many roles of complement for SLE pathogenesis and how research has progressed during recent years. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4454030
- author
- Leffler, Jonatan
LU
; Bengtsson, Anders
LU
and Blom, Anna
LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Annals of the Rheumatic Diseases
- volume
- 73
- issue
- 9
- pages
- 1601 - 1606
- publisher
- BMJ Publishing Group
- external identifiers
-
- pmid:24845390
- wos:000340723700009
- scopus:84905191911
- pmid:24845390
- ISSN
- 1468-2060
- DOI
- 10.1136/annrheumdis-2014-205287
- language
- English
- LU publication?
- yes
- id
- b2330b97-86f6-44be-abf5-b2a5490fc823 (old id 4454030)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24845390?dopt=Abstract
- date added to LUP
- 2016-04-01 10:17:37
- date last changed
- 2022-05-05 20:21:22
@article{b2330b97-86f6-44be-abf5-b2a5490fc823, abstract = {{The complement system plays a major role in the autoimmune disease, systemic lupus erythematosus (SLE). However, the role of complement in SLE is complex since it may both prevent and exacerbate the disease. In this review, we explore the latest findings in complement-focused research in SLE. C1q deficiency is the strongest genetic risk factor for SLE, although such deficiency is very rare. Various recently discovered genetic associations include mutations in the complement receptors 2 and 3 as well as complement inhibitors, the latter related to earlier onset of nephritis. Further, autoantibodies are a distinct feature of SLE that are produced as the result of an adaptive immune response and how complement can affect that response is also being reviewed. SLE generates numerous disease manifestations involving contributions from complement such as glomerulonephritis and the increased risk of thrombosis. Furthermore, since most of the complement system is present in plasma, complement is very accessible and may be suitable as biomarker for diagnosis or monitoring of disease activity. This review highlights the many roles of complement for SLE pathogenesis and how research has progressed during recent years.}}, author = {{Leffler, Jonatan and Bengtsson, Anders and Blom, Anna}}, issn = {{1468-2060}}, language = {{eng}}, number = {{9}}, pages = {{1601--1606}}, publisher = {{BMJ Publishing Group}}, series = {{Annals of the Rheumatic Diseases}}, title = {{The complement system in systemic lupus erythematosus: an update.}}, url = {{https://lup.lub.lu.se/search/files/1721403/4940709.pdf}}, doi = {{10.1136/annrheumdis-2014-205287}}, volume = {{73}}, year = {{2014}}, }