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Antibiotic regimens with rifampicin for treatment of Enterococcus faecium in biofilms.

Holmberg, Anna LU and Rasmussen, Magnus LU (2014) In International Journal of Antimicrobial Agents 44(1). p.78-80
Abstract
Enterococcus faecium is an important pathogen that is resistant to many antibiotics and is able to form biofilms on implanted medical devices. In this study, the efficacy of rifampicin-containing antibiotic regimens against biofilms of E. faecium in vitro was investigated by determination of the minimum biofilm eradication concentration and by time-kill experiments of bacteria in biofilms formed on beads of bone cement. Rifampicin combined with tigecycline, daptomycin or linezolid was more efficient in reducing bacterial numbers and halting the development of rifampicin resistance than the combination of rifampicin and vancomycin.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Antimicrobial Agents
volume
44
issue
1
pages
78 - 80
publisher
Elsevier
external identifiers
  • pmid:24837415
  • wos:000339793500012
  • scopus:84902544701
ISSN
1872-7913
DOI
10.1016/j.ijantimicag.2014.03.008
language
English
LU publication?
yes
id
91a6346d-34df-4d00-ac7f-69738f56e2fa (old id 4454233)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24837415?dopt=Abstract
date added to LUP
2014-06-04 21:25:57
date last changed
2017-09-10 03:17:58
@article{91a6346d-34df-4d00-ac7f-69738f56e2fa,
  abstract     = {Enterococcus faecium is an important pathogen that is resistant to many antibiotics and is able to form biofilms on implanted medical devices. In this study, the efficacy of rifampicin-containing antibiotic regimens against biofilms of E. faecium in vitro was investigated by determination of the minimum biofilm eradication concentration and by time-kill experiments of bacteria in biofilms formed on beads of bone cement. Rifampicin combined with tigecycline, daptomycin or linezolid was more efficient in reducing bacterial numbers and halting the development of rifampicin resistance than the combination of rifampicin and vancomycin.},
  author       = {Holmberg, Anna and Rasmussen, Magnus},
  issn         = {1872-7913},
  language     = {eng},
  number       = {1},
  pages        = {78--80},
  publisher    = {Elsevier},
  series       = {International Journal of Antimicrobial Agents},
  title        = {Antibiotic regimens with rifampicin for treatment of Enterococcus faecium in biofilms.},
  url          = {http://dx.doi.org/10.1016/j.ijantimicag.2014.03.008},
  volume       = {44},
  year         = {2014},
}