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Sugar-Bile Acid-Based Bolaamphiphiles: From Scrolls to Monodisperse Single-Walled Tubules.

Gubitosi, Marta LU ; Travaglini, Leana; D'Annibale, Andrea; Pavel, Nicolae V; Vázquez Tato, José; Obiols-Rabasa, Marc LU ; Sennato, Simona; Olsson, Ulf LU ; Schillén, Karin LU and Galantini, Luciano (2014) In Langmuir 30(22). p.6358-6366
Abstract
The introduction of a mannose residue on carbon 3 of lithocholic acid gives rise to an asymmetric and rigid bolaamphiphilic molecule, which self-assembles in water to form elongated tubular aggregates with an outer diameter of about 20 nm. These tubular structures display a temporal evolution, where the average tube diameter decreases with time, which can be followed by time-resolved small-angle X-ray scattering experiments. Cryogenic transmission electron microscopy images collected as a function of time show that at short times after preparation tubular scrolls are formed via the rolling of layers, after which a complex transformation of the scrolls into single-walled tubules takes place. At long time scales, a further evolution occurs... (More)
The introduction of a mannose residue on carbon 3 of lithocholic acid gives rise to an asymmetric and rigid bolaamphiphilic molecule, which self-assembles in water to form elongated tubular aggregates with an outer diameter of about 20 nm. These tubular structures display a temporal evolution, where the average tube diameter decreases with time, which can be followed by time-resolved small-angle X-ray scattering experiments. Cryogenic transmission electron microscopy images collected as a function of time show that at short times after preparation tubular scrolls are formed via the rolling of layers, after which a complex transformation of the scrolls into single-walled tubules takes place. At long time scales, a further evolution occurs where the tubules both elongate and become narrower. The observed self-assembly confirms the tendency of bile acids and their derivatives to form supramolecular aggregates with an ordered packing of the constituent molecules. It also demonstrates that scrolls can be formed as intermediate structures in the self-assembly process of monodisperse single-walled tubules. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Langmuir
volume
30
issue
22
pages
6358 - 6366
publisher
The American Chemical Society
external identifiers
  • pmid:24827467
  • wos:000337198900007
  • scopus:84902137948
ISSN
0743-7463
DOI
10.1021/la500908r
language
English
LU publication?
yes
id
ab451960-d35f-4cb6-b568-5de31d65576a (old id 4455224)
date added to LUP
2014-06-18 14:59:26
date last changed
2017-10-01 03:29:16
@article{ab451960-d35f-4cb6-b568-5de31d65576a,
  abstract     = {The introduction of a mannose residue on carbon 3 of lithocholic acid gives rise to an asymmetric and rigid bolaamphiphilic molecule, which self-assembles in water to form elongated tubular aggregates with an outer diameter of about 20 nm. These tubular structures display a temporal evolution, where the average tube diameter decreases with time, which can be followed by time-resolved small-angle X-ray scattering experiments. Cryogenic transmission electron microscopy images collected as a function of time show that at short times after preparation tubular scrolls are formed via the rolling of layers, after which a complex transformation of the scrolls into single-walled tubules takes place. At long time scales, a further evolution occurs where the tubules both elongate and become narrower. The observed self-assembly confirms the tendency of bile acids and their derivatives to form supramolecular aggregates with an ordered packing of the constituent molecules. It also demonstrates that scrolls can be formed as intermediate structures in the self-assembly process of monodisperse single-walled tubules.},
  author       = {Gubitosi, Marta and Travaglini, Leana and D'Annibale, Andrea and Pavel, Nicolae V and Vázquez Tato, José and Obiols-Rabasa, Marc and Sennato, Simona and Olsson, Ulf and Schillén, Karin and Galantini, Luciano},
  issn         = {0743-7463},
  language     = {eng},
  number       = {22},
  pages        = {6358--6366},
  publisher    = {The American Chemical Society},
  series       = {Langmuir},
  title        = {Sugar-Bile Acid-Based Bolaamphiphiles: From Scrolls to Monodisperse Single-Walled Tubules.},
  url          = {http://dx.doi.org/10.1021/la500908r},
  volume       = {30},
  year         = {2014},
}