Advanced

Risk of neurodisability and other long-term outcomes for infants born following assisted reproductive technologies.

Källén, Bengt LU (2014) In Seminars in Fetal & Neonatal Medicine 19(4). p.239-244
Abstract
Children born after assisted reproductive technologies (ART) have an increased morbidity. The risk of developing cerebral palsy is nearly doubled and the risk of developing epilepsy is also higher. Behavioural problems including attention deficit/hyperactivity disorder may be more common in children born following ART than among naturally conceived children but the finding is uncertain. Data on autism are difficult to interpret. There may exist a small increase in the incidence of childhood cancer and there is greater evidence of an elevated risk of asthma. To some extent, these risks are mediated by neonatal complications including prematurity and low birth weight but some effects such as cerebral palsy are likely to be linked to the... (More)
Children born after assisted reproductive technologies (ART) have an increased morbidity. The risk of developing cerebral palsy is nearly doubled and the risk of developing epilepsy is also higher. Behavioural problems including attention deficit/hyperactivity disorder may be more common in children born following ART than among naturally conceived children but the finding is uncertain. Data on autism are difficult to interpret. There may exist a small increase in the incidence of childhood cancer and there is greater evidence of an elevated risk of asthma. To some extent, these risks are mediated by neonatal complications including prematurity and low birth weight but some effects such as cerebral palsy are likely to be linked to the increased rate of multiple births after ART. Many of the neonatal complications after ART are most likely linked to parental subfertility and are less an effect of the ART technology. The possibility exists that imprinting errors, associated with subfertility and/or ART, may result in long-term morbidity. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Seminars in Fetal & Neonatal Medicine
volume
19
issue
4
pages
239 - 244
publisher
Elsevier
external identifiers
  • pmid:24793634
  • wos:000340699700005
  • scopus:84904820750
ISSN
1878-0946
DOI
10.1016/j.siny.2014.04.002
language
English
LU publication?
yes
id
e7aa90b4-18c8-4d89-8628-4c7d3fad7671 (old id 4455920)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24793634?dopt=Abstract
date added to LUP
2014-06-03 18:59:56
date last changed
2017-02-22 10:46:23
@article{e7aa90b4-18c8-4d89-8628-4c7d3fad7671,
  abstract     = {Children born after assisted reproductive technologies (ART) have an increased morbidity. The risk of developing cerebral palsy is nearly doubled and the risk of developing epilepsy is also higher. Behavioural problems including attention deficit/hyperactivity disorder may be more common in children born following ART than among naturally conceived children but the finding is uncertain. Data on autism are difficult to interpret. There may exist a small increase in the incidence of childhood cancer and there is greater evidence of an elevated risk of asthma. To some extent, these risks are mediated by neonatal complications including prematurity and low birth weight but some effects such as cerebral palsy are likely to be linked to the increased rate of multiple births after ART. Many of the neonatal complications after ART are most likely linked to parental subfertility and are less an effect of the ART technology. The possibility exists that imprinting errors, associated with subfertility and/or ART, may result in long-term morbidity.},
  author       = {Källén, Bengt},
  issn         = {1878-0946},
  language     = {eng},
  number       = {4},
  pages        = {239--244},
  publisher    = {Elsevier},
  series       = {Seminars in Fetal & Neonatal Medicine},
  title        = {Risk of neurodisability and other long-term outcomes for infants born following assisted reproductive technologies.},
  url          = {http://dx.doi.org/10.1016/j.siny.2014.04.002},
  volume       = {19},
  year         = {2014},
}