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Leukocyte telomere length is not associated with mortality in older men.

Svensson, Johan; Karlsson, Magnus LU ; Ljunggren, Osten; Tivesten, Asa; Mellström, Dan and Movérare-Skrtic, Sofia (2014) In Experimental Gerontology 57(Apr 30). p.6-12
Abstract
Leukocyte telomere length (LTL) is related to the aging of somatic cells. We hypothesized that LTL is inversely associated with mortality in elderly men. LTL was measured in 2744 elderly men (mean age 75.5, range 69-81years) included in the prospective population-based MrOS-Sweden study. Mortality data were obtained from national health registers with no loss of follow-up. During the follow-up (mean 6.0years), 556 (20%) of the participants died. Using Cox proportional hazards regression, tertile of LTL did not associate with all-cause mortality [tertile 1 (shortest) or 2 (middle) vs. tertile 3 (longest); hazard ratio (HR)=1.05, 95% confidence interval (CI) 0.85-1.28 and HR=0.97, 95% CI 0.79-1.19, respectively]. Furthermore, LTL did not... (More)
Leukocyte telomere length (LTL) is related to the aging of somatic cells. We hypothesized that LTL is inversely associated with mortality in elderly men. LTL was measured in 2744 elderly men (mean age 75.5, range 69-81years) included in the prospective population-based MrOS-Sweden study. Mortality data were obtained from national health registers with no loss of follow-up. During the follow-up (mean 6.0years), 556 (20%) of the participants died. Using Cox proportional hazards regression, tertile of LTL did not associate with all-cause mortality [tertile 1 (shortest) or 2 (middle) vs. tertile 3 (longest); hazard ratio (HR)=1.05, 95% confidence interval (CI) 0.85-1.28 and HR=0.97, 95% CI 0.79-1.19, respectively]. Furthermore, LTL did not associate with cancer (197 events) or cardiovascular disease (CVD, 206 events) mortality (tertile 1 vs. tertile 3; HR=0.94, 95% CI 0.67-1.34 and HR=0.94, 95% CI 0.68-1.30, respectively). The lack of association between LTL and mortality remained also after adjustment for multiple covariates. Our results demonstrate that LTL is not associated with all-cause mortality or mortality due to cancer or CVD in elderly men. Further studies are needed to determine whether LTL can predict the risk of mortality in elderly women. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Experimental Gerontology
volume
57
issue
Apr 30
pages
6 - 12
publisher
Elsevier
external identifiers
  • pmid:24793325
  • wos:000341374300002
  • scopus:84899786113
ISSN
1873-6815
DOI
10.1016/j.exger.2014.04.013
language
English
LU publication?
yes
id
d7fe6f7a-b3d7-4874-bbcf-d632f9a98b64 (old id 4455924)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24793325?dopt=Abstract
date added to LUP
2014-06-03 19:06:48
date last changed
2017-07-23 03:08:13
@article{d7fe6f7a-b3d7-4874-bbcf-d632f9a98b64,
  abstract     = {Leukocyte telomere length (LTL) is related to the aging of somatic cells. We hypothesized that LTL is inversely associated with mortality in elderly men. LTL was measured in 2744 elderly men (mean age 75.5, range 69-81years) included in the prospective population-based MrOS-Sweden study. Mortality data were obtained from national health registers with no loss of follow-up. During the follow-up (mean 6.0years), 556 (20%) of the participants died. Using Cox proportional hazards regression, tertile of LTL did not associate with all-cause mortality [tertile 1 (shortest) or 2 (middle) vs. tertile 3 (longest); hazard ratio (HR)=1.05, 95% confidence interval (CI) 0.85-1.28 and HR=0.97, 95% CI 0.79-1.19, respectively]. Furthermore, LTL did not associate with cancer (197 events) or cardiovascular disease (CVD, 206 events) mortality (tertile 1 vs. tertile 3; HR=0.94, 95% CI 0.67-1.34 and HR=0.94, 95% CI 0.68-1.30, respectively). The lack of association between LTL and mortality remained also after adjustment for multiple covariates. Our results demonstrate that LTL is not associated with all-cause mortality or mortality due to cancer or CVD in elderly men. Further studies are needed to determine whether LTL can predict the risk of mortality in elderly women.},
  author       = {Svensson, Johan and Karlsson, Magnus and Ljunggren, Osten and Tivesten, Asa and Mellström, Dan and Movérare-Skrtic, Sofia},
  issn         = {1873-6815},
  language     = {eng},
  number       = {Apr 30},
  pages        = {6--12},
  publisher    = {Elsevier},
  series       = {Experimental Gerontology},
  title        = {Leukocyte telomere length is not associated with mortality in older men.},
  url          = {http://dx.doi.org/10.1016/j.exger.2014.04.013},
  volume       = {57},
  year         = {2014},
}