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An inherited variant in the gene coding for vitamin D-binding protein and survival from cutaneous melanoma: a BioGenoMEL study

Davies, John R.; Field, Sinead; Randerson-Moor, Juliette; Harland, Mark; Kumar, Rajiv; Anic, Gabriella M.; Nagore, Eduardo; Hansson, Johan; Hoeiom, Veronica and Jönsson, Göran B LU , et al. (2014) In Pigment Cell & Melanoma Research 27(2).
Abstract
An association between low serum vitamin D levels and poorer melanoma survival has been reported. We have studied inheritance of a polymorphism of the GC gene, rs2282679, coding for the vitamin D-binding protein, which is associated with lower serum levels of vitamin D, in a meta-analysis of 3137 melanoma patients. The aim was to investigate evidence for a causal relationship between vitamin D and outcome (Mendelian randomization). The variant was not associated with reduced overall survival (OS) in the UK cohort, per-allele hazard ratio (HR) for death 1.23 (95% confidence interval (CI) 0.93, 1.64). In the smaller cohorts, HR in OS analysis was 1.07 (95% CI 0.88, 1.3) and for all cohorts combined, HR for OS was 1.09 (95% CI 0.93, 1.29).... (More)
An association between low serum vitamin D levels and poorer melanoma survival has been reported. We have studied inheritance of a polymorphism of the GC gene, rs2282679, coding for the vitamin D-binding protein, which is associated with lower serum levels of vitamin D, in a meta-analysis of 3137 melanoma patients. The aim was to investigate evidence for a causal relationship between vitamin D and outcome (Mendelian randomization). The variant was not associated with reduced overall survival (OS) in the UK cohort, per-allele hazard ratio (HR) for death 1.23 (95% confidence interval (CI) 0.93, 1.64). In the smaller cohorts, HR in OS analysis was 1.07 (95% CI 0.88, 1.3) and for all cohorts combined, HR for OS was 1.09 (95% CI 0.93, 1.29). There was evidence of increased melanoma-specific deaths in the seven cohorts for which these data were available. The lack of unequivocal findings despite the large sample size illustrates the difficulties of implementing Mendelian randomization. (Less)
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@article{3b718d7a-9563-4a26-8ecd-e07c759f8e64,
  abstract     = {An association between low serum vitamin D levels and poorer melanoma survival has been reported. We have studied inheritance of a polymorphism of the GC gene, rs2282679, coding for the vitamin D-binding protein, which is associated with lower serum levels of vitamin D, in a meta-analysis of 3137 melanoma patients. The aim was to investigate evidence for a causal relationship between vitamin D and outcome (Mendelian randomization). The variant was not associated with reduced overall survival (OS) in the UK cohort, per-allele hazard ratio (HR) for death 1.23 (95% confidence interval (CI) 0.93, 1.64). In the smaller cohorts, HR in OS analysis was 1.07 (95% CI 0.88, 1.3) and for all cohorts combined, HR for OS was 1.09 (95% CI 0.93, 1.29). There was evidence of increased melanoma-specific deaths in the seven cohorts for which these data were available. The lack of unequivocal findings despite the large sample size illustrates the difficulties of implementing Mendelian randomization.},
  author       = {Davies, John R. and Field, Sinead and Randerson-Moor, Juliette and Harland, Mark and Kumar, Rajiv and Anic, Gabriella M. and Nagore, Eduardo and Hansson, Johan and Hoeiom, Veronica and Jönsson, Göran B and Gruis, Nelleke A. and Park, Jong Y. and Guan, Jian and Rachakonda, P. Sivaramakrishna and Wendt, Judith and Pjanova, Dace and Puig, Susana and Schadendorf, Dirk and Okamoto, Ichiro and Olsson, Hakan and Affleck, Paul and Garcia-Casado, Zaida and Anton Puig-Butille, Joan and Stratigos, Alexander J. and Kodela, Elizabeth and Donina, Simona and Sucker, Antje and Hosen, Ismail and Egan, Kathleen M. and Barrett, Jennifer H. and van Doorn, Remco and Bishop, D. Timothy and Newton-Bishop, Julia},
  issn         = {1755-148X},
  keyword      = {vitamin D,melanoma,survival analysis,mendelian randomization,GC},
  language     = {eng},
  number       = {2},
  publisher    = {Wiley-Blackwell},
  series       = {Pigment Cell & Melanoma Research},
  title        = {An inherited variant in the gene coding for vitamin D-binding protein and survival from cutaneous melanoma: a BioGenoMEL study},
  url          = {http://dx.doi.org/10.1111/pcmr.12193},
  volume       = {27},
  year         = {2014},
}